Grab a coffee and enjoy reading up on CO metabolism in methanotrophs!
Freshwater ANME (own work):
www.nature.com/articles/s41...
Marine ANME (@Orphan lab):
www.nature.com/articles/s41...
Big thanks to our collaborators at QUT!
@sjmcilroy.bsky.social (Heyu/Andy/Gene!) @cuwelte.bsky.social
Posts by Kathryn (Katy) Appler
Preprint out!
Anaerobic methanotrophs are key methane oxidizers, but their activity/adaptation under acidic conditions remains unclear. We show that a freshwater ANME adapts to pH stress via shifts in lipid composition and remains metabolically active down to pH 5.65. Expanding the niche of ANME.
How diverse is bacterial immunity ?
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
Congratulations, Heidi!
How do you make methane from phosphite? Through interspecies H2 transfer! Our paper on lithosyntrophy is finally published - read about how we resolved the metabolic interactions in this phosphite oxidizing, methanogenic enrichment culture! #phosphorus #methanogenesis www.pnas.org/doi/10.1073/...
Just over ten years after the discovery of the first Asgard archaeal genomes, we revisit the rapid expansion of this remarkable archaeal lineage. From diverse genomes and metabolisms to eukaryotic signature proteins and the first cultured representatives.
www.nature.com/articles/s41...
Congratulations to Stephan and everyone involved!
Check out his thread to learn more 🧵
Finally out in @natmicrobiol.nature.com: Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Great work by @stephkoe.bsky.social @kassipan.bsky.social @jvhooff.bsky.social
www.nature.com/articles/s41...
Scientists are one step closer to understanding the origins of complex life on Earth after shedding new light on a mystery about our microbial ancestors. https://cnn.it/4srOEWd
Can't miss this amazing study on the ribosome structure of the Haloferax archaeon 👏🏼👏🏼👏🏼!! Congrats to my good friend @diorgeps.bsky.social and all the other ppl involved!!
New preprint! We propose "anergiobiosis" to describe microbial life at thermodynamic limits as a way of separating the physiological state from questions about aeonophilic extremophile specialization. ecoevorxiv.org/repository/v...
#Microbiology #Extremophiles #SubsurfaceMicrobiology #MicroSky
Thanks Reinier!!!
Thanks, Pia! Hope you are doing well!!
Thanks!!
Thanks Basile 😊
Thanks Miguel!!
Thanks, Pedro! Congrats to you too!
Thanks, Anthony!!
Nature research paper: Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor
go.nature.com/4rSfRRw
#NatMicroPicks
Aerobic archaeal-eukaryotic ancestor? 🦠🫁
The ancestor of eukaryotes may have combined hydrogen metabolism with aerobic respiration, shaping early cellular complexity.
#MicroSky
www.nature.com/articles/s41...
Hot eukaryogenesis news (is there any other kind?) - hydrogen production and aerobic respiration may have been present in the Asgard-eukaryotic ancestor - paper in @nature.com www.nature.com/articles/s41...
Thanks, I cannot wait for our next project! 😊
New research in @nature.com funded by our Life Sciences division: "Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor." https://www.nature.com/articles/s41586-026-10128-z
Thanks for all of your wonderful work on this project! I very much enjoyed working together and hope we can again soon!
Eukaryogenesis in light of an expanded catalogue of Asgard genomes. a, Simplified, scaled timeline spanning from before the Last Asgard archaea Common Ancestor (LAsCA) to today. Thin bands mark predicted time ranges of relevant events (for example, GOE), thicker bands represent processes (for example, eukaryogenesis), and brackets indicate the period shown in b. The timeline further highlights milestones, including potential early eukaryotic fossils60 and the modern-day co-occurrence of Heimdallarchaeia and Alphaproteobacteria observed in this study (interaction likely originated earlier).
Fig. 1 | Expanded genomic diversity of Asgard archaea. a, Maximum-likelihood phylogeny based on 47 non-ribosomal markers (NM47)using the WAG + C10 + R4 model with 100 nonparametric bootstrap pseudoreplicates, including 869 Asgardarchaeota MAGs and 309 outgroup genomes. The blue branches (lower right) indicate the new Asgardarchaeota classes, Ranarchaeia, and the recently proposed Asgardarchaeia4. The concentric rings denote (in to out): the predicted genome size, metabolic guilds based on Pfam clustering, sampling locations, and black stars on the outside mark MAGs added by this study. Asgard, Asgardarchaeia; Atabey, Atabeyarchaeia; Baldr, Baldrarchaeia; Frey/Jord, Frey/Jordarchaeia; Gerd, Gerdarchaeales; Heimdall, Heimdallarchaeaceae; Hel, Helarchaeales; Hermod, Hermodarchaeia; Hod, Hodarchaeales; Kari, Kariarchaeaceae; Loki, Lokiarchaeales; Njord, Njordarchaeales; Odin, Odinarchaeia; Ran, Ranarchaeia; Sif, Sifarchaeia; Thor, Thorarchaeia; Wukong, Wukongarchaeia. b, SR4-recoded phylogeny of the same genome set inferred with the model GTR + C60 + G and 100 nonparametric bootstrap pseudoreplicates (Methods). This updated catalogue constitutes a large increase in the medium- to high-quality publicly available genomes (completeness >50% and contamination and redundancy <10%) with 65.3% from the Guaymas Basin and 34.7% from the Bohai Sea. The encircled numbers represent MAGS added by this study. The scale bars in bothsubpanels represent the average number of substitutions per site.Map created in BioRender; Appler, K. https://biorender.com/147ieoc(2025).
Our work is published today: ‘Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor’. This was a huge effort lead by @katyappler.bsky.social. Extremely grateful to have been a part of this amazing project! 😊🦠🧬
Links: www.nature.com/articles/s41...
www.nature.com/articles/s41...
I will add if there's any wonder how much work this study was just have a look at the 170 pages SI file! static-content.springer.com/esm/art%3A10...
new study of #GreatLakes research centers, w/ some nice quotes from CIGLR colleagues: "Research centers in the region also work together as a collaborative that complements each of them, and so the network of research centers is vital, Moerke said."...
greatlakesecho.org/2026/02/16/r...
Some of our earliest microbial ancestors, the Asgard archaea, were able to use oxygen, says new study in @nature.com. It may solve a mystery about how complex life first arose.
#AsgardArchaea #MicrobialEcology #Eukaryogenesis #TexasScience @utmsi.bsky.social @archaeal.bsky.social