🚨 New lab preprint alert! 🚨
A study 6 years in the making, made possible by @simonsfoundation.org support : "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" now on #biorXiv: www.biorxiv.org/content/10.6... A 🧵 1/11 🧪🖥️🧬
A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging
🤩 @bbparis1984.bsky.social
doi.org/10.64898/202...
A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging
www.biorxiv.org/content/10.6...
🚨LA and SoCal trainees: Submit your abstracts for #GLAM2026 - we have 16 grad/postdoc talk slots and 12 undergraduate talk slots! 🚨
🔥 Attention Los Angeles and SoCal Geroscience trainees 🔥: Registration and abstract submission for the 2026 ✨ Geroscience Los Angeles Meeting (GLAM) ✨ are open:
gero.usc.edu/laara/event/...
#GLAM2026 will take place September 4th, 2026 at the California Science Center 🧪 🔬 👩🔬 👨🔬
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A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging www.biorxiv.org/content/10.64898/2026.04...
Thank you Javier! ☺️
Thank you!😊
🚨 AGE VOYAGER Grants are OPEN! 🚨
✔️ Up to $5,000
✔️ For AGE trainee members (grad students & postdocs)
✔️ Supports travel, lodging, registration, childcare & more
🗓 Deadline: Jan 12, 2026
#AGEVoyager #AgingResearch #Geroscience #ResearchFunding #AGE
We hope you will enjoy the read as much as we enjoyed working on this project! 😍
@uscleonarddavis.bsky.social 11/11
This study provides a powerful resource and framework to leverage the killifish 🐟 to rapidly test pathways driving 🧠 aging! This work came to life thanks to talented lab members led by #RaphealWilliams, #BryanTeefy & #AaronLemus, and help from our collaborators #StevenMcCarroll and #JohnTower. 10/11
🔥 Indeed, mid-life-initiated glucocorticoid antagonism with #mifepristone is sufficient to curb brain aging-associated transcriptional changes and microglia expansion (suggesting this intervention may potentially increase brain health span, at least in this species).🔥 9/11
These observations prompted a crazy 🤪 gambit - what if counteracting #glucocorticoid signalling before #cortisol levels spike (say, at middle age) could prevent or slow down the onset of aging phenotypes? 🤔 8/11
and (iii) our data predicted widespread activation of hashtag#glucocorticoid signalling as a hallmark of brain aging (with conservation in publicly available human 🙍♀️ 🙍♂️ and mouse 🐁 datasets). Consistently, we saw increased cortisol production in old 👵 fish tissues! 7/11
(ii) age-related gene expression changes reported with human 🙍♀️ 🙍♂️ and mouse 🐁 aging are clearly conserved in hashtag#killifish, 6/11
We made several interesting observations: (i) #microglia expand in numbers with aging and acquire an "activated" phenotype, regardless of sex and strain (which we confirmed using #RNAscope imaging), 5/11
We were able to identify and annotate all major #brain cell types expected in a Vertebrate: neurons, astrocytes, microglia, oligodendrocytes, etc and to determine potential shifts in relative cell abundances using our single cell level data. 4/11
Our goal: identifying robust, conserved genetic pathways that may regulate Vertebrate #brain 🧠 #aging. We used a combination of single-nuclei RNA-seq and single nuclei ATAC-seq (@10xgenomics.bsky.social) together with bulk ATAC-seq to create an atlas of brain aging across the lifespan. 3/11
As part of the #Simons Collaboration for Plasticity in the Aging Brain's conserved pathway group, we embarked on an effort to map brain 🧠 #aging in the short-lived African turquoise killifish 🐟, using females ♀️ and males ♂️, across 2 strains with different captive lifespans. 2/11
🚨 New lab preprint alert! 🚨
A study 6 years in the making, made possible by @simonsfoundation.org support : "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" now on #biorXiv: www.biorxiv.org/content/10.6... A 🧵 1/11 🧪🖥️🧬
Trainees at the undergraduate, graduate and postdoctoral levels are encouraged to submit an abstract for consideration through the conference website.
Abstracts submitted until June 1st can be considered for oral presentations, and the final talk lineup will be announced by July 31st! 2/2
🔥 Attention Los Angeles and SoCal Geroscience trainees 🔥: Registration and abstract submission for the 2026 ✨ Geroscience Los Angeles Meeting (GLAM) ✨ are open:
gero.usc.edu/laara/event/...
#GLAM2026 will take place September 4th, 2026 at the California Science Center 🧪 🔬 👩🔬 👨🔬
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Please share with your #killifish colleagues 🐟 #ZebrafishMeeting
Beyond depressing situation for aging research funding in the US.
A line graph showing the fraction of R01 applications funded as a function of percentile for NIA. The estimated success rate for FY2024 was 15.8% compared with 5.8% for FY2025.
12/25
Retired NIH Program Officer Requests Grandson Address Weaknesses From Last Year’s Christmas List Before Considering New Submission
open.substack.com/pub/inprepar...
Excited to share our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by Dr. #MinhooKim, published online today at @nataging.nature.com, where we describe surprising findings on the gut/ovary axis. 🧪🖥️🧬. A 🧵1/11 www.nature.com/articles/s43...
Happy Women's Day! Is there a better way to celebrate than reading the latest 📄 on our fav. female cells?
👉🏼 biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41776310/ by @bbparis1984.bsky.social on the role of microbiota in ovarian aging!
powered by @biomednews.bsky.social #cebooc
Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social
doi.org/10.1038/s435...
✨Registration is OPEN for the 2026 FASEB on Epigenetics in Aging and Disease in Malahide, Ireland!✨
Featuring @denadubal.bsky.social and Yang Shi from @ludwigcancer.bsky.social as Keynotes. Speaker slots available!
With: @bbparis1984.bsky.social Ashby Morrison, Ernesto Guccione