These observations prompted a crazy 🤪 gambit - what if counteracting #glucocorticoid signalling before #cortisol levels spike (say, at middle age) could prevent or slow down the onset of aging phenotypes? 🤔 8/11
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Hashtag
#glucocorticoid
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New article to read from @ki.se! Flare risk after oral #glucocorticoid bridging with #methotrexate or intra-articular bridging with triple therapy in early #rheumatoid arthritis.
🔗 doi.org/10.1111/joim.70094
#InternalMedicine #RA
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Don't miss out on this great new review! Stomach at the crossroads: nuclear receptor signaling at the interface between what we are and what we eat.
Margarita Divenko and Jason C. Mills
➡️https://ow.ly/UNK850YCObB
#estrogen #glucocorticoid #retinoid
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Patient education on #glucocorticoid stress dosing is key to the effective prevention of #adrenal #crises and their associated morbidity and mortality. All patients with #Addison’s disease should be given a steroid emergency card thelancet.com/journals/lan...
#Addison's disease
#MedSky #EndoSky
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Patient education on #glucocorticoid #stress #dosing is key to the effective prevention of #adrenal #crises and their associated morbidity and mortality thelancet.com/journals/lan...
#Addison's disease
primary #adrenal insufficiency
#MedSky #EndoSky
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Fragility fractures remain a common and serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to #fractures owing to its high proportion of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#EndoSky
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"evidence..provides a coherent pic of the [ #Glucocorticoid ] dilemma. Adverse effects of GCs are clearly tied to long-term use, regardless of dose under 5 mg/day. Data from large cohorts indicate increased risks of #cardiovascular issues.": buff.ly/YzVVYKk
via @cureusmedical.bsky.social
#lupus #RA
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Patient education on #glucocorticoid stress dosing is key to the effective prevention of #adrenal #crises and their associated morbidity and mortality www.thelancet.com/journals/lan...
#Addison's disease
#adrenal insufficiency
#MedSky #EndoSky
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Fragility #fractures remain a common & serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
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"A significant risk associated with long-term [ #Glucocorticoid ] therapy is suppression of the #HPAaxis, which wld cause life-threatening #AdrenalInsufficiency on #withdrawal .. #ClinicalTrials [reveal] a significant unreported prevalence of [that].": buff.ly/StB5JAI
via @cureusmedical.bsky.social
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Fig. 4 Species variation in relative g lucocor ticoid abundance. (A) For four out of the five species tested, the release rate of corticosterone was lower than the release rate of cortisol. In D. tinctorius , corticosterone was released 1.64 times more than cortisol. Larger dots indicate the mean for each group. Smaller dots represent individual samples (NS = not significant, * = P < 0.05, ** = P < 0.001, *** = P < 0.0001). (B) The species names correspond to the respective photos beneath the x -axis labels. The tree below the photos indicates the #phylogenetic relationships between species (Guillory et al. 2019 ).
"We originally set out to validate non-invasive waterborne hormone measurements in our focal species..."
from
Why not both? A case study in measuring cortisol and #corticosterone
By
Westrick , Paitz , Fischer
doi.org/10.1093/iob/...
#hormones #frogs #glucocorticoid #science #physiology #biology
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IOB
Why not both? A case study in measuring #cortisol and #corticosterone
by S. E. Westrick et al
doi.org/10.1093/iob/...
"A general tenet in stress physiology is that the #hypothalamic- #pituitary-adrenal axis predominantly produces one #glucocorticoid (GC) in response to stressors..."
#frogs
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"1 reason [ #glucocorticoid ] should be withdrawn is to prevent permanent, irreversible organ damage. The organ damage among #SLE patients is a fundamental outcome measure for tapering [ #glucocorticoids ].": buff.ly/7S5yqYD
via @cureusmedical.bsky.social
#MedSky #rheumatology #lupus #RA #steroids
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Individuals on long-term oral #glucocorticoid treatment display an estimated prevalence of #osteoporosis or fractures as high as 30–50%, rendering glucocorticoid therapy the most common cause of secondary and iatrogenic osteoporosis thelancet.com/journals/lan...
#MedSky #EndoSky #RheumSky
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Fragility #fractures remain a common & serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to fractures owing to its high proportion of trabecular bone thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
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Vasily from our team was invited to present at the #NRRN meeting on “Conformational Dynamics and Chromatin Assembly of #Glucocorticoid Receptor Using Topological Modeling and Single-Molecule Analysis.” Looking forward to connecting with researchers on advances in nuclear receptor research.
#ChemSky
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We discovered that the "orphan" nuclear receptor Nur77 binds DNA under regulation by #glucocorticoid receptor & glucocorticoids. The synthetic glucocorticoid dexamethasone directly interacts with Nur77, revealing a new function for this drug & a potential ligand for Nur77.
doi.org/10.1101/2025...
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Fragility #fractures remain a common & serious complication of long-term oral #glucocorticoid therapy that might affect all #skeletal sites, although the spine is particularly prone to fractures owing to its high proportion of trabecular #bone thelancet.com/journals/lan...
#OpenAccess
#EndoSky
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#Glucocorticoid treatment has become the most common drug-induced form of #osteoporosis because of its broad therapeutic use for various inflammatory & haematological diseases & its pivotal role in transplantation medicine www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #RheumSky
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Fragility #fractures remain a common and serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#EndoSky
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This condition is associated with increased morbidity and mortality, often due to inadequate #glucocorticoid replacement.
There are now case reports of adrenal crisis secondary to #COVID infections, this is the 1st reported case of a new diagnosis of #Addisonsdisease presenting
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From #ENDO2025: In pediatric #CongenitalAdrenalHyperplasia, crinecerfont is associated with sustained reductions in androstenedione levels and #glucocorticoid doses at 1 year.
@endocrinesociety.bsky.social
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Combination #Cyclophosphamide and #Rituximab to Minimize #Glucocorticoid Use in Antineutrophil Cytoplasm Antibody–Associated Vasculitis #ANCA
#VisualAbstract by @KajareeG
www.kireports.org/ar...
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A and B) C57BL/6J mice were treated with 0.1 IU ACTH via subcutaneous injection. Serum corticosterone (A) and Δcorticosterone (B) levels were measured before and 1 hour after the ACTH test (n = 6). Data are presented as mean ± SEM. Statistical testing using 2-tailed unpaired Student’s t test. (C) C57BL/6J mice were challenged with CLP (25G, full ligation) for different times (0, 3, 24, 48 hours). Serum corticosterone and IL-6 levels were measured (n = 6–9). (D and E) C57BL/6J mice were challenged with CLP (25G, full ligation) for different times (0, 3, 24, 48 hours). Then, the mice were treated with 0.1 IU ACTH. Serum corticosterone (D) and Δcorticosterone (E) levels were measured before and 1 hour after the ACTH test (n = 6). (F and G) C57BL/6J mice were challenged with CLP for different times (0, 3, 24, 48 hours). Then, mice were treated with 4 IU ACTH. Serum corticosterone (F) and Δcorticosterone (G) levels were measured before and 1 hour after the ACTH test (n = 7–9). Data are presented as mean ± SEM. Statistical testing using 1-way ANOVA with Tukey’s multiple-comparison correction. (H and I) C57BL/6J mice were challenged with or without CLP for 3 hours (H) and stimulated with ACTH (4 IU) or PBS for 45 minutes (I). GC synthesis–related gene expression in the adrenal gland was analyzed by RNA-seq analysis. Data are presented as mean ± SEM. Statistics using 2-way ANOVA with Tukey’s multiple-comparison correction. NS, no significance; *P < 0.05; **P < 0.01; ****P < 0.0001. For RNA-seq analysis, pairwise comparisons between the various conditions were run using a negative binomial generalized log-linear model through the glmLRT fit function in edgeR (https://bioconductor.org/packages/release/bioc/html/edgeR.html).
#Medsky🧪 #IDSky #immunosky #ICU #pharmasky this study reveal flaws in #adrenocorticotropichormone ( ACTH) test for diagnosing adrenal insufficiency in #sepsis underscoring a need for a new diagnosis & reevaluation of #glucocorticoid therapy
insight.jci.org/articles/vie...
@jci-insight.bsky.social
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A step towards more physiological #glucocorticoid dosing in congenital #adrenal #hyperplasia www.thelancet.com/journals/lan...
#MedSky #EndoSky
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Exposed mothers and their children also had significantly lower #cortisol and #glucocorticoid receptor levels than the non-exposed group, and elevated #mineralocorticoid receptor levels
5/11
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Real-world oral #glucocorticoid use in #SLE: a nation-wide population-based study using the French medico-administrative (SNDS) claim database
lupus.bmj.com/content/12/1...
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New report shows transcutaneous auricular #vagus #nerve stimulation to inhibit mental stress-induced #cortisol release, with implications for improving #glucocorticoid dysfunction in #chronic #inflammation conditions.
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Low versus high initial oral glucocorticoid dose for lupus nephritis: a pooled analysis of randomised controlled clinical trials
#lupusnephritis #glucocorticoid #autoimmune
lupus.bmj.com/content/12/1...
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Grant R. Laskin et al. found that short-term aerobic exercise prevents development of #glucocorticoid myopathic features in aged skeletal #muscle in a sex-dependent manner 🏃💉
📜 Read the #Research here: https://buff.ly/3BUspUo
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