Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest Background New postoperative atrial fibrillation (POAF) occurs in about 40% after cardiac surgery. Mineralocorticoid receptor antagonists (MRA) are known to reduce chronic atrial fibrillation (AF) dev...

Single nucleus #RNAseq of human atria reveals a subpopulation of cardiac myocytes with high expression of #mineralocorticoid receptor target genes in atrial fibrillation. This confirms nicely what we found in experimental models, coming soon. www.biorxiv.org/content/10.1... #AF

Exposed mothers and their children also had significantly lower #cortisol and #glucocorticoid receptor levels than the non-exposed group, and elevated #mineralocorticoid receptor levels
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