Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation

#Glucocorticoids increase clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by inhibiting H4K12 lactylation, highlighting a promising combinatorial strategy for treating #RenalCancer.
#STTT #OpenAccess: doi.org/10.1038/s413...

IOB, Now in issue!

State-Dependent and Social Modulation of Circulating #Glucocorticoids in a Nomadic #Songbird, the Red #Crossbill (Loxia Curvirostra)

(cover photo) Neil Paprocki
Vernasco et al

doi.org/10.1093/iob/...

#birds #biology #hormones #ecology #endocrine

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

High cumulative doses of exogenous #glucocorticoids lead to a spectrum of side-effects, in particular increased #fracture risk. Fragility fractures might result in immobility, frequent admission to hospitals, and loss of quality of life thelancet.com/journals/lan...
#osteoporosis

#MedSky #EndoSky

Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis Abstract. One of the major metabolic functions of glucocorticoids (GC) is to maintain circulating glucose levels during stress, as glucose is the preferred

Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis. Read more in #EndocrineReviews: bit.ly/3YS3bxH #Glucocorticoids #Gluconeogenesis #InsulinResistance @endocrinesociety.bsky.social

#quotes #books #booksky #excerpts #citations #determined #sapolsky #freewill #behavior #brain #neurobiology #psychology #glucocorticoids #stress #depression #anxiety #androgen #aggression #emotion #empathy #alcoholism #criminal #pregnancy #mother

"1 reason [ #glucocorticoid ] should be withdrawn is to prevent permanent, irreversible organ damage. The organ damage among #SLE patients is a fundamental outcome measure for tapering [ #glucocorticoids ].": buff.ly/7S5yqYD

via @cureusmedical.bsky.social
#MedSky #rheumatology #lupus #RA #steroids

Research Article

Assessment of Giant Cell Arteritis–Associated Visual Outcomes at a Tertiary Hospital in Ontario, Canada

📖 www.jrheum.org/cgi/content/...
@matsjunek.bsky.social @rahulchanchlani.bsky.social @macdeptmed.bsky.social

#GiantCellArteritis #Vasculitis #Glucocorticoids

Anthony Etyang

#ResearchHighlight from Anthony Etyang @kemriwellcome.bsky.social

A Pragmatic Trial of #Glucocorticoids for Community-Acquired #Pneumonia

Read more 👉 www.ndm.ac/tropmed.res-hi
Full publication 👉 www.nejm.org/doi/full/10....

Avacopan Does Not Raise Risk of Severe Infection in AAV A meta-analysis of patients with AAV found that infection risk does not differ between those taking avacopan and those taking glucocorticoids.

#ACR25: Compared to those who receive #Glucocorticoids, patients with #ANCA-associated vasculitis (#AAV) who receive #Avacopan are not at increased risk of infection, according to a recent meta-analysis. Presented at ACR Convergence 2025

Read more: https://bit.ly/47bymsH

#RareDisease #RheumSky

High cumulative doses of exogenous #glucocorticoids lead to a spectrum of side-effects, in particular increased #fracture risk. Fragility fractures might result in immobility, frequent admission to hospitals, and loss of quality of life thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

Acute antilipolytic effects of elevated levels of corticosterone in differentiated murine white adipocytes - PubMed Glucocorticoids (GC) are a group of steroid hormones that affect white adipose tissue (WAT) lipogenesis (biosynthesis of triglycerides) and lipolysis (hydrolysis of triglycerides). At the cellular lev...

🔥 Beaudry Lab is on a roll! Acute, high corticosterone suppresses lipolysis in White Adipose Tissue independent of the GR. First evidence of non-GR effects in WAT (seen before only in smooth muscle & bronchial cells). pubmed.ncbi.nlm.nih.gov/40833836/ #Adipose #Glucocorticoids #Metabolism

Chronodisruption also called #circadian misalignment can lead to impaired mental &physical health (impaired #cognition, #sleep & #health problems, increasing risks of #chronic diseases &cancer) Dysregulation of endocrine systems plays a key role with #glucocorticoids & #melatonin being prime targets

#Medsky🧪 #IDsky #pharmsky #publichealth GRADE Evidence Profile: In patients hospitalized with severe or critical #COVID receiving systemic #glucocorticoids, should abatacept compared to no #abatacept be added to standard care?

Glucocorticoid Therapy Beneficial in IgAN | Docwire News Crescents and cellular segmental sclerosis predicted greater benefit from glucocorticoids in IgA nephropathy (IgAN).

Crescents and cellular segmental sclerosis predicted greater benefit from #glucocorticoids in #IgAnephropathy. #nephsky #igan www.docwirenews.com/post/glucoco...

Research Article

Long-Term Effectiveness and Safety of Denosumab for Osteoporosis in Patients With Rheumatic Diseases

📖 www.jrheum.org/cgi/content/...

#denosumab #glucocorticoids #osteoporosis

"In cases of severe, refractory or worsening #hypophysitis after initial therapy with #glucocorticoids, non-glucocorticoids immunosuppressive therapy could be a safe and effective alternative to control symptoms and #pituitary stalk thickening." -- Janaki Vakharia, MD. #ENDO2025 #EndoSky

Research Article

Achievement and Usefulness of Intermediate Treatment Targets for Still Disease Proposed by @eular.org and the Paediatric Rheumatology European Society

📖 www.jrheum.org/cgi/content/...

#Stilldisease #glucocorticoids #recurrence

Calling on all #wildlife ecologists! I am looking for time-stamped longitudinal fecal collections from #mammals (n>250; spread throughout the day; frozen at min -20*C; ideally, repeated sampling) - please DM me #feces #poop #faeces #droppings #scat #microbiome #MEvSky #glucocorticoids #diet

Minimizing Glucocorticoid Use in Patients With ANCA-Associated Vasculitis | Docwire News A study found that combination cyclophosphamide and rituximab therapy for severe ANCA-associated vasculitis to minimize glucocorticoid use may reduce morbidity.

Cyclophosphamide-rituximab therapy and minimal use of glucocorticoids in ANCA-associated vasculitis may reduce morbidity. #AAV #ANCAvasculitis #nephrology #rituximab #cyclophosphamide #glucocorticoids www.docwirenews.com/post/minimiz...

Blood pressure and its associations in 554 children and young people with congenital adrenal hyperplasia by Neil R Lawrence et al

EJE Volume 192, Issue 5, May 2025
Open access 👉 doi.org/10.1093/ejen...

#endocrinology #CAH #glucocorticoids #hyperplasia

Insights from Neurocrine Biosciences on High-Dose Glucocorticoid Effects in Congenital Adrenal Hyperplasia Neurocrine Biosciences sheds light on how high doses of glucocorticoids affect clinical outcomes in patients with congenital adrenal hyperplasia during ISPOR 2025.

Insights from Neurocrine Biosciences on High-Dose Glucocorticoid Effects in Congenital Adrenal Hyperplasia #United_States #San_Diego #Neurocrine #Congenital_Adrenal_Hyperplasia #Glucocorticoids

#astrocytes #neuroinflammation #Alzheimers #Parkinsons #ecology #publichealth #gerontology #neuroscience #triclocarban #microbiome #healthinformatics #AI #datascience #geriatrics #ataxia #rheumatoid #arthritis #healthy #ageing #aging #health #menopause #neurology #biomonitoring #glucocorticoids

Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis Glucocorticoids regulate hematopoiesis, but how chronic elevation of endogenous glucocorticoid production affects hematopoietic stem cell (HSC) function and immune cell development remains incompletel...

Our latest preprint shows what prolonged glucocorticoid exposure can do to the immune system: HIF1⬇️🐁->GC⬆️(+Receptor)-HSPC->Immune❄️☀️ www.biorxiv.org/content/10.1... CRC-TRR 205 @adrenal-research.bsky.social ! #hypoxia #glucocorticoids #HIF #HSC #Immunology

#prednisone #corticosteroids #glucocorticoids #agedcare #publichealth #diabetes #aging #gerontology #geriatrics #dementia #Alzheimers #endocrinology #health #NCDs

Prednisolone
impairs different aspects of pancreatic β-cell function,
increasing the risk of diabetes
.
academic.oup.com/ejendo/artic...

Research Article

Tocilizumab (TCZ) for Giant Cell Arteritis: Clinical Outcomes Following Relapses and TCZ Discontinuation Due to Adverse Events

📖 www.jrheum.org/cgi/content/...

#giantcellarteritis #vasculitis #glucocorticoids #tocilizumab

Off-label use of biologics in urticarial vasculitis: a European retrospective cohort study AbstractObjectives. Urticarial vasculitis (UV) is characterized by atypical urticarial lesions and leukocytoclastic vasculitis, sometimes with extracutaneo

👀Off-label use of biologics in urticarial vasculitis: a European retrospective cohort study

#Vasculitis #Biologics #Rituximab #Hydroxychloroquine #Glucocorticoids

academic.oup.com/rheumatology...

🧠Using #organoids, @le-and-er.bsky.social and his colleagues found that #glucocorticoids, often prescribed before premature delivery, alter the neuronal balance in the developing brain.

🥳 Check out his summary below! 🧪

#neuroskyence #PsychSciSky

Impact of Surreptitious Glucocorticoids in Over-the-Counter Arthritis Supplements Abstract. Adrenal dysfunction due to over-the-counter (OTC) health supplements containing unlabeled glucocorticoids has been previously reported. Here, we

Case series documents serious impacts of surreptitious #glucocorticoids in over-the-counter #arthritis supplements. Featured study in #JES. #OpenAccess. #bone
@endocrinesociety.bsky.social
doi.org/10.1210/jend...

Research Article

Symptom Severity and Glucocorticoid Dosing in Patients With Polymyalgia Rheumatica and Obesity

📖 www.jrheum.org/cgi/content/...

#glucocorticoids #obesity #polymyalgiarheumatica

Fresh publication alert! 🔥
"Breeding #fattaileddunnarts in #captivity: revised practices to minimise #stress whilst maintaining considerations of wild #biology".
#glucocorticoids #endocrinology #captivemanagement #marsupials doi.org/10.1002/dvdy...