Abatacept could delay rheumatoid arthritis for high-risk patients One year of treatment with biologic drug abatacept (Orencia; Bristol Myers Squibb) delays progression to rheumatoid arthritis (RA) for up to four years in high-risk patients, according to the results…

Study results suggest that one year of treatment with biologic drug #abatacept delays progression to #rheumatoidarthritis for up to four years in high-risk patients

#orencia #RA #arthritis #clinicalresearch #biologics

buff.ly/GP1eWdj

Peripheral T Lymphocyte Activation State May Predict Abatacept Response in IgG4-RD New research showed that patients with rare variants affecting the CTLA-4 pathway were more likely to respond to abatacept than those without the variants.

Investigators have found that baseline T-cell activation patterns may predict which patients with immunoglobulin G4-related disease (#IgG4RD) are more likely to respond to #Abatacept, according to a letter to the editor in the European Journal of Internal Medicine.

Read more: https://bit.ly/3Me1kzY

Warning Signs of Rheumatoid Arthritis Detected Years Before Symptoms

Researchers found proteins elevated years before joint inflammation in people with anticitrullinated protein antibodies (ACPAs); abatacept has been trialed to delay RA onset. getnews.me/warning-signs-of-rheumat... #rheumatoidarthritis #abatacept

New study shows abatacept’s effect on T cells is short-lived in vivo. Once treatment stops, immune activity rebounds quickly, important insight for #RA therapy and immune modulation. 🧬

Read more: https://bit.ly/4aDHTrm

#Immunology #TCells #Abatacept

#Medsky🧪 #IDsky #pharmsky #publichealth GRADE Evidence Profile: In patients hospitalized with severe or critical #COVID receiving systemic #glucocorticoids, should abatacept compared to no #abatacept be added to standard care?

What happens in pre-RA when you stop #abatacept after 1 yr Rx

At 6 yrs approx 60% on #Placebo
V
50% who initially got #ABA

Prolonged damped effect of development of #RA

NNT for 1 yr is ~10 with a range as low as 6

#EULAR2025 @RheumNow @eular_org
Abst#OP0004 buff.ly/M9TEJum

Research Article

Association Between Abatacept Exposure Levels and Infection Occurrence in Patients With Rheumatoid Arthritis: Post Hoc Analysis of the AVERT-2 Study

📖 doi.org/10.3899/jrhe...

#abatacept #infection #rheumatoidarthritis

Risque de cancer au cours de la polyarthrite rhumatoïde - Rhumatos Risque par rapport à la population générale et associé aux traitements Le cancer, première cause de mortalité en France, touche particulièrement les patients atteints de polyarthrite rhumatoïde (PR), ...

🧐Le risque de #cancer est-il plus élevé dans la #PR ? La réponse dans le dernier Rhumatos

👉 rhumatos.fr/risque-de-ca...

#AntiTNP #abatacept #JAKi #tocilizumab #ritixumab

ReadingRheum Notes🛋️:

#Abatacept for Pre-RA?
(high risk & + Abs, no synovitis)
Yay✅? or Nay🚫?
pubmed.ncbi.nlm.nih.gov/38364839/