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WCN26-2413 SYNERGISTIC EFFECTS OF TRF-BUDESONID AND SPARSENTAN IN IGA-NEPHROPATHY Sparsentan has emerged as a promising therapeutic option for IgA nephropathy (IgAN) while Targeted-release formulation (Trf-) Budesonid is an established treatment for patients with persistent protein...

This is not at all surprising, and it lends support for other combination therapies that have different mechanisms of action and targets. www.kireports.org/article/S246...

#NephSky #IgANephropathy #IgAN

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Did you know that the โ€œfour-hitโ€ hypothesis for IgA nephropathy #IgAN was first clearly articulated by Hitoshi Suzuki et al. in their 2011 J. Am. Soc. Nephrol. paper, โ€œThe pathophysiology of IgA nephropathy.โ€
#ISNWCN ๐Ÿ‡ฏ๐Ÿ‡ต #WCN26 ๐Ÿ‡ฏ๐Ÿ‡ต #WCN2026 ๐Ÿ‡ฏ๐Ÿ‡ต
#Nephpearls #NephSky

๐Ÿ‘‰ pubmed.ncbi.nlm.nih.gov/21949093/

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Therapeutic targets ๐ŸŽฏand positioning of treatments in IgA nephropathy ๐Ÿ”ฌ #IgAN ca. 2026 from @kidneyint.bsky.social
#ISNWCN ๐Ÿ‡ฏ๐Ÿ‡ต #WCN26 ๐Ÿ‡ฏ๐Ÿ‡ต #WCN2026 ๐Ÿ‡ฏ๐Ÿ‡ต
#Nephpearls #NephSky

๐Ÿ‘‰ pubmed.ncbi.nlm.nih.gov/41895685/

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Efficacy and Safety of Atrasentan in Patients with #IgAN Receiving Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i) ca. 2026 from @asnpublications.bsky.social
#ISNWCN ๐Ÿ‡ฏ๐Ÿ‡ต #WCN26 ๐Ÿ‡ฏ๐Ÿ‡ต #WCN2026 ๐Ÿ‡ฏ๐Ÿ‡ต
#Nephpearls #NephSky

Photo Credit: @nephroseeker.medsky.social

๐Ÿ‘‰ journals.lww.com/jasn/fulltex...

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Trying to catch up with #IgAN trialsโ‰๏ธ

Check out ๐Ÿ‘‰ โ€œIgAN: An Overview of the Clinical Trialsโ€ ca. 2025 from @kidneymed.bsky.social @haresh11.bsky.social @alexgr23.bsky.social @saynanorouzi.bsky.social
#ISNWCN ๐Ÿ‡ฏ๐Ÿ‡ต #WCN26 ๐Ÿ‡ฏ๐Ÿ‡ต #WCN2026 ๐Ÿ‡ฏ๐Ÿ‡ต
#Nephpearls #NephSky

๐Ÿ‘‰ pubmed.ncbi.nlm.nih.gov/41050133/

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Pathogenesis of IgA Nephropathy #IgAN
#ISNWCN ๐Ÿ‡ฏ๐Ÿ‡ต #WCN26 ๐Ÿ‡ฏ๐Ÿ‡ต #WCN2026 ๐Ÿ‡ฏ๐Ÿ‡ต
#Nephpearls #NephSky

๐Ÿ‘‰ pubmed.ncbi.nlm.nih.gov/37742867/

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Pillars of IgA Nephropathy #IgAN Treatment
#ISNWCN ๐Ÿ‡ฏ๐Ÿ‡ต #WCN26 ๐Ÿ‡ฏ๐Ÿ‡ต #WCN2026 ๐Ÿ‡ฏ๐Ÿ‡ต
#Nephpearls #NephSky

๐Ÿ‘‰๐Ÿผ pubmed.ncbi.nlm.nih.gov/38398259/

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I hope having my voice amplified by @ajkd.bsky.social will help clinicians and patients.

#IgANephropathy #IgAN #NephSky #MedSky

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A little something I wrote about the patient perspective of disease: www.sciencedirect.com/science/auth...

#IgANephropathy #IgAN #NephSky #MedSky

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Evidence from multicenter clinical studies and humanized mouse models indicates that glomerular mesangial IgA2 deposition contributes to the pathogenesis of IgA nephropathy

doi.org/10.1016/j.kint.2026.02.018

#MedSky #NephSky #IgAN @nu-nephrology.bsky.social

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Commentary
The expanding role of complement inhibitors in the treatment of IgA nephropathy

doi.org/10.1016/j.kint.2025.12.015

Original article: doi.org/10.1016/j.kint.2025.11.017

#MedSky #NephSky #IgAN @ucm.es

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The Batang Igan Bridge has officially opened, ending over 30 years of ferry service for residents. The bridge now cuts travel time from 30 minutes to just a few minutes.

Read more: sarawakdaily.com/batang-igan-...

#Mukah #Igan #Matu #Sarawak #Infrastructure #SarawakDaily #KuchingKing

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Graphical abstract

Graphical abstract

Very cool

Enteric coated budesonide also reduces albuminuria, and GFR remains stable in #IgAN

Single arm prospective study from India in KI Reports

www.kireports.org/article/S246...

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Check out our review "IgA Nephropathy #IgAN: An Overview of the Clinical Trials" #Nephmadness write up
#Nephpearls #NephSky

๐Ÿ‘‰ pubmed.ncbi.nlm.nih.gov/41050133/

๐Ÿ‘‰ NephMadness ajkdblog.org/2026/03/01/n...

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Check out the KDIGOโ€“@medliveofficial.bsky.social CME program, โ€œAdvancing Renal Protection in IgA Nephropathy,โ€ now available on demand.

Register and watch now: bit.ly/4aM5lW9

Learn the latest strategies to reduce proteinuria, slow eGFR decline, and improve long-term kidney outcomes in #IgAN.

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Today is rare disease day! I made this infographic about my condition a while ago, but I wanted to share again today to help raise awareness ๐Ÿ’™ #rarediseaseday #igan

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Dose 2 of sibeprenlimab complete. Ask me anything.

#iganephropathy #igan #nephsky

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Novartis Vanrafiaยฎ Phase III data support slowing of kidney function decline in patients with IgA nephropathy

Atrasentan is back: www.novartis.com/news/media-r...

ALIGN study: www.nejm.org/doi/full/10....

brand name โ€˜Vanrafiaโ€™

#NephSky #IgAN

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I am now going through another hospital's Transplant program.

Medical bills are piling up, so I'm resharing this information.

My sister is
@sassyscifichick.bsky.social

#Kidney #Transplant #IgANephropathy #CKD #Dialysis #GoFundMe #IgAN #Medical #Bills #Travel #Hospital #Doctors #KidneyTransplant

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Currently doing N=1 test of COVID vs. sibeprenlimab, wish me luck.

#IgAN #IgANephropathy #NephSky

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This cold has reached man-cold status. Spent all day sleeping off and on on the sofa. Hope it doesn't progress beyond this.

#IgAN #IgANephropathy #NephSky #sibeprenlimab

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New York Presbyterian Rogosin Institute invites you to The Julie Lam & Kapil Mathur Education and Prevention Initiative IgAN Webinar
"Understanding the Latest KDIGO Guidelines for IgA Nephropathy Care"
presented by James Chevalier, MD
Monday, March 2, 2026 at 7:00 PM
Please register: https://cvent.me/EaEvoV

New York Presbyterian Rogosin Institute invites you to The Julie Lam & Kapil Mathur Education and Prevention Initiative IgAN Webinar "Understanding the Latest KDIGO Guidelines for IgA Nephropathy Care" presented by James Chevalier, MD Monday, March 2, 2026 at 7:00 PM Please register: https://cvent.me/EaEvoV

The Rogosin Institute invites you to their FREE Education and Prevention Initiative #IgAN Webinar โ€œUnderstanding the Latest KDIGO Guidelines for IgA Nephropathy Careโ€ presented by James Chevalier, MD Monday, March 2, 2026 at 7:00 PM.
Please register: cvent.me/EaEvoV

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BHV-1400 is exciting stuff.

#IgAN #IgANephropathy #NephSky

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Now I get to see just how effective sibeprenlimab is since my high schooler politely gave me a cold over the weekend. Thankfully, it's not yet evolved to a man cold.

#IgAN #IgANephropathy #NephSky

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How the 2025 KDIGO Guidelines Are Personalizing IgA Nephropathy Care, With Gerald Appel, MD | HCPLive 2025 KDIGO guidelines reshape IgA nephropathy care with earlier biopsy, tighter proteinuria targets, and personalized treatment strategies.

Gerald Appel, MD from @columbiamed explains how the evolving #IgAN treatment landscape, in tandem with @gokdigo 2025 updated guidelines, has shifted management toward a more personalized approach.

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Low-grade proteinuria, whether assessed at baseline or over time, is an important predictor of kidney disease progression in patients with IgA nephropathy #IgAN ca. 2026 from @asnpublications.bsky.social
#Nephpearls #NephSky

๐Ÿ‘‰๐Ÿผ pubmed.ncbi.nlm.nih.gov/41385286/

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