Live human pancreas slice with islet cells stained red.
With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc
Close up with a beautiful nudibranch on a rocky reef. The lower half of the image is a palette of swatches made from the nudi's vibrant colours.
Once upon a time I just admired nudis and sea slugs.
But it was not enough. Now apparently I'm creating an R package to celebrate their colour palettes? 😅
First up, my Sydney fave, Hypselodoris bennetti.
#rstats #nudibranch #dataviz 🦑🐙🧪 #marinelife #invertebrates
"i have two Microsoft Outlooks, and neither one of those are working."
The Astronauts truly representing us all up there.
Pleased to share our latest research where we investigated a potential new drug for type 1 diabetes in slices of living human pancreas tissue from nPOD donors
#industrycollaboration with Immunocore
@bruskolab.bsky.social @ufbme.bsky.social @ufresearch.bsky.social
www.science.org/doi/10.1126/...
My main gripe with the alphafold example is how it shows you need decades and decades of high quality data, well structured, open and accessible to train a model -- and yet they always gloss over it and pretend it's just AI and magic. No, we need to continuously invest in real data and FAIR data.
Trick question. Use Hoechst-S76912 (nuclear yellow). Frees up 405 channel.
PSA: Do not take your plasmids for granted. Sequence EVERYTHING. Trust no one.
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira
www.sciencedirect.com/science/arti...
LOVE the audio signal in the supplementary videos. Wonderfully creative interpretive aid for the reader/listener. Excellent data, cool work! Congrats!
New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
Nuc Yellow
Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD
www.cell.com/cell-reports...
I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress.
link.springer.com/article/10.1... 🔓
When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday
How academics imagine their lives would look like if they decide to work in tech
I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
very sorry to hear about your loss of Rosa
Great session on biomaterials for beta cell replacement in T1D at #SFB2025. Thanks to all the speakers and co-organizer Jess Weaver.
CaMPARI2 provides a marker of beta-cell function, allowing high content analysis
Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
New aquarium denizens
Listen to my interview on our local NPR station @wuft.org show "Tell Me About It" to learn more about this awesome event to connect the public with the research we do on UF's campus. www.wuft.org/podcast/tell...
UF Biomedical Engineering STEM Outreach Day Date/Time Date(s) - 03/08/2025 10:00 am - 1:00 pm Location Reitz Student Union Join us on Saturday, March 8, 2025, from 10 a.m. to 1 p.m. at the Reitz Student Union on the UF campus for a free, family-friendly event designed to spark curiosity and inspire the next generation of STEM leaders. This outreach event is perfect for students in grades K-12, offering an exciting glimpse into the world of biomedical engineering—a field where science, technology, engineering, and mathematics come together to revolutionize healthcare.
Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too!
bme.ufl.edu/events/uf-bi...
