Researchers standing in front of whiteboard with scientific information

WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field.

Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social

www.wehi.edu.au/news/new-enz...

And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...

I am deeply saddened learning that my scientific hero Amos Bairoch has recently passed away. He will be remembered as the mastermind behind the SwissProt and many other endeavours in protein bioinformatics. There is a tribute web page at sib.swiss/amos/

great job! Very statesman-like. I wish I would have learned to give dignified answers like yours, without offending anybody! Do you guys train situations like these? Just being envious.

‼️It was wonderful to have Professor Kay Hoffmann at the #AusUb25 - and even better to get the chance to interview him! Hear about his experiences in industry and academia as well as his love for proteins😁

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.

ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane Deubiquitinases (DUBs) remove ubiquitin modifications from proteins in a substrate- or linkage-selective manner and regulate numerous cell-biological processes, including endocytosis. By performing ho...

For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...