Not all important science confirms a hypothesis.

Null findings are a critical part of the research process—but they’re often left unpublished.

We’re highlighting why (and how to change that) in the latest edition of our new FASEB Publications LinkedIn Newsletter 👇
buff.ly/mSBPnUm

Sure, happy to send it via Mail.

A young child with brown hair looks off to the side with a thoughtful expression against a soft gray background. Above her, bold text reads: “The science life depends on. Let’s drive physiology forward.” The word “life” is written in colorful script, and “physiology” is underlined in pink.

Today, APS is launching Physiology: The Science Life Depends On, a campaign to champion #physiology and protect the science behind every breakthrough. It's time to reintroduce physiology to the world, together. Join the #FightForPhysiology at fightforphysiology.org 🧪

Same for me, thanks!

Call for Letters on Durability, Fatigability, Resilience, and Repeatability <p>The <em>Journal of Applied Physiology</em> publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.</p><p>The wide scientific span of the Journal rests on physiology as its keystone. However, the boundaries of physiology have enlarged as demarcations between concepts and techniques in the physiological, pharmacological, and biochemical sciences become increasingly blurred. Moreover, theoretical articles on research at any level of biological organization ranging from molecules to humans fall within the broad scope of the Journal. Papers dealing with topics in other basic sciences that impinge on physiology are also welcome.</p>

📢 July 23 Deadline for JAPPL Call for Letters:

Submit your LTE about “Viewpoint: Durability, Fatigability, Repeatability and Resilience in Endurance Sports: Definitions, Distinctions, and Implications.” Read the Call for Letters requirements: journals.physiology.....

🧠💬 JAP invites Letters on our Viewpoint (w/ @billysperlich.bsky.social) on #durability, #fatigability, #repeatability & #resilience. Share your take & shape the debate!
🔗 Viewpoint: https://doi.org/10.1152/japplphysiol.00343.2025
🔗 Call: journals.physiology.org/jappl/cfp-endurance-spor...

Durability, Fatigability, Repeatability and Resilience in Endurance Sports: Definitions, Distinctions, and Implications | Journal of Applied Physiology | American Physiological Society

Now available here: journals.physiology.org/doi/abs/10.1...

#Durability ≠ #Fatigability ≠ #Repeatability ≠ #Resilience.
Our JAP Viewpoint (accepted!) dives into why these distinct concepts matter in endurance research.
Grateful for the collab with Michael J Joyner + @billysperlich.bsky.social.
Let’s discuss at #ECSS2025 or during the Tour de France!

I’ve been waiting for that one! Looking forward to dive in deep!

Zone 2 Intensity: A Critical Comparison of Individual Variability in Different Submaximal Exercise Intensity Boundaries Introduction: Endurance athletes often utilize low-intensity training, commonly defined as Zone 2 (Z2) within a five-zone intensity model, for its potential to enhance aerobic adaptations and metabol....

Link to the full paper. Open access and highly recommended reading. onlinelibrary.wiley.com/doi/full/10....

Experiment and learn your response!

Another paper on zone 2 training that neatly demonstrates the great variety in responses of differen intensity markers.

In my opinion, yet another reminder for why you shouldn’t rely on one intensity marker (or generic %HR or %FTP ranges).

And an experiment observing reliability & agreement of common methods to estimate the upper boundary of "zone 2" from HR, lactate, ventilation, RPE, etc.

Meixner B, et al. 2025. Zone 2 Intensity: A Critical Comparison of Individual Variability... onlinelibrary.wiley.com/doi/full/10....

Zone2 training may not deliver the same benefits for everyone. Our new study found substantial interindividual variability in physiological responses, even among trained cyclists, indicating that personalized intensity prescriptions are necessary. @billysperlich.bsky.social
doi.org/10.1155/tsm2...

Supplementation of Creatine Monohydrate improves sprint performance but has no effect on glycolytic contribution: A Non-Randomized, Placebo-Controlled Crossover Trial in Trained Cyclists Summary: Creatine loading supplementation increases 15s-work while hinting at different mechanisms involved in its effects on individual limitations to 15s-work.

Our recent study included the effects of creatine supplementation on vlamax-testing. The results imply that some athletes may be limited by their metabolism while others could be limited by the testing setup. Read more about it here:
cdn.nutrition.org/article/S247...
@billysperlich.bsky.social