I’m so honored to be included in this Hypothesis Fund cohort and grateful for this investment in our research! 🥲

5/ Awardee @heatherfeaga.bsky.social is investigating how bacteria decide when to go dormant💤 (ie, form spores). Her project could lead to important new advancements in the management of spore-forming bacteria in the environment, hospitals, & food supply.
🎉 Congrats Dr. Feaga!
🙏 #HFScout Dipti Nayak

Very exciting that our new paper on the forces exerted by the Rad51-Rad54 homology search complex is now online. This was a collaborative effort with the Wang here at Cornell, and this work performed primarily by a graduate student, Mitch Woodhouse
genesdev.cshlp.org/content/earl...

Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1 | PNAS Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transientl...

Very proud of this tour de force from two former students, Stephanie Tanis and Leah Simon, with help from a huge team, including @charlesdanko.bsky.social highlighting a novel-overlooked intervention point for male contraception

www.pnas.org/doi/10.1073/...

I mean WTAF?

Happy Retirement Bob!

April 1st is officially halfway through the fiscal year. It is probably related to that, and yes I agree it stinks.

All year? Because a lot of grants weren't ready for the council.

There are so many places that are warm right now, and yet it is snowing in Ithaca...

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

2026 is turning into a real banger

Living in Ithaca New York you learn there are many different kinds of snow

Happy to share our perspective on the DNA translocation mechanism by the CMG helicase.

DNA translocation by the CMG helicase: the helical inchworm model url: portlandpress.com/biochemsoctr...

rince & JB Editor's Choice: Lin, Prince & Feaga identified sporulation genes via analyzing almost 1500 genomes. They show that that an unusual membrane-localized variant of Spo0B is found throughout Paenibacillaceae.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)

🗓 May 30–31, 2026

✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.

Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...

Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2 Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p

🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...

no mercy for junior faculty

Weill Institute is recruiting postdocs, please share!

Fischer Lab: lnkd.in/eMnveqyv

Hu Lab: lnkd.in/epsGK7wd

You say board of peace, I say legion of Doom. I think we can work this out.

Just kidding

And now we wait

Remember when data not shown was a thing

A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch. 

doi.org/10.64898/202...

My first first-author paper is posted! Glad to have this out! 🦠🚨🕺

We show that pGpp production depletes GTP, inhibits translation, and remodels the transcriptome faster than (p)ppGpp.

...and more!

We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com!

Open access link: www.nature.com/articles/s41...

(1/9)

Manuscript accepted. I have allowed myself 30 minutes to celebrate and will move on to the next.

Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social

Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social

journals.asm.org/doi/10.1128/...