An April Fools joke about a "discovery" of fully glycosylated molecules.

We are proud to announce the discovery of Glyco-Carbohydrates, a paradigm shift in glycobiology! Traditional glycoconjugates (proteins, lipids & RNA) max out at 50% carbohydrate.

Ours are 100% carbohydrate AND glycans, unlocking truly homogenous properties.

TBA April 1st, 2027! 🍬 #glycotime

Defective HLA-G1 glycosylation disrupts Siglec-7–mediated NK cell tolerance at the maternal–fetal interface in recurrent pregnancy loss
link.springer.com/article/10.1...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Emerging roles of ILC2 in neuronal crosstalk across organs. In a series of studies published in 2025, ILC2 were shown to regulate nervous system function across a range of organs across the body. Wit...

@hepworth-lab.bsky.social new paper alert. Matt and I wrote a research highlight about recent papers that describe mechanisms of ILC2-neuron crosstalk. If you're interested in reading it, check it out!
onlinelibrary.wiley.com/doi/10.1111/...

Dr. Joan Chang, Junior PI YouTube video by ASMB - American Society for Matrix Biology

Our #JuniorPI feature for #ASMB2025 spotlights @tranejoan.bsky.social from @officialuom.bsky.social, whose work explores collagen homeostasis in fibrosis and repair🔬 She is also co‑chair of ASMB Outreach, strengthening community engagement.🎥-https://youtu.be/abjDOI39WJY
@themeshwork.bsky.social

Thanks, pleased we will be able to cite your new paper in the published version soon, the really crazy bit is the need for cxcl4 signaling through proteoglycans for the effect on neurons! Glycobiology is so exciting at the moment!!

Looks exciting, you might be interested in our study of proteoglycan shuttling of chemokine across the BBB, www.biorxiv.org/content/10.1...

Organized immunity in the CNS: What stroke reveals about neuroinflammation and lymphoid niches: doi.org/10.1172/JCI2...

Catalina Lee-Chang comments on Yang et al.: doi.org/10.1172/JCI1...

Frontiers | Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review BackgroundAge is a major risk factor for ischemic stroke (IS), with immunosenescence–age-related immune system dysfunction - contributing to worse outcomes. ...

Interested in how age related immune dysfunction might impact stroke risk and outcomes? Check out our systematic review led by Vanda Wen Teng Ho at the National University of Singapore
www.frontiersin.org/journals/agi...

Long-lived resident tissue macrophages govern intraocular pressure homeostasis by regulating extracellular matrix turnover, contributing to resistance-generating tissues that are dysfunctional in glaucoma @cp-immunity.bsky.social
www.cell.com/immunity/ful... @dukeeyecenter.bsky.social

Native PGC-LC–MS profiling reveals distinct O-acetylation patterns of Sialylated N-glycans across mammalian sera Abstract. O-acetylation of sialic acids represents an additional layer of structural diversity and biological complexity, occurring at various hydroxyl pos

Pleased to share our native glycomics workflow preserving O-acetylation, detecting this labile modification in rat (53%) and mouse (9%) serum N-glycans.

Integrally, O-acetyls are invisible under standard reductive conditions.
Now published at Molecular Omics.

Link: academic.oup.com/molecular-om...

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

Review @annualreviews.bsky.social @gabyrabi.bsky.social
Glycan-Binding Proteins in Immunity
www.annualreviews.org/content/jour...

Flyer of the Matrix Biology Europe conference listing invited speakers

Registration for #MBE2026 is now open!
Join us in Oulu 🇫🇮 for the flagship European meeting dedicated to fundamental #ECM research.
ECRs and trainees, this is a unique chance to connect with leaders in the field, present your work, gain visibility, and build your network!
More at www.mbe2026.org

You still have 3 days to apply to the postdoc positions available in my lab 😀
🔬Come and work with us 🔬

(President's Doctoral Scholar Award) A mechanistic understanding of microbe-immune cross talk in the face of pollutant challenge at The University of Manchester on FindAPhD.com PhD Project - (President&#39;s Doctoral Scholar Award) A mechanistic understanding of microbe-immune cross talk in the face of pollutant challenge at The University of Manchester, listed on FindAPhD.c...

📣 2026 PhD studentship 📣
Via @manchester.ac.uk 's President's Doctoral Scholar Awards, we are encouraging applications for a PhD on the effect of pollutant exposure on microbe-immune cross talk. This project will incorporate microbiology, immunology, & bioinformatics. Deadline: 16 March 2026!

One week left to submit your abstract for this fantastic meeting 👇 It’s gonna be a great year for matrix meetings! 😎 Fancy a full week of matrix biology? Catch a direct flight from Manchester to Frankfurt after #BSMB and join us in Heidelberg for #DGMB2026 😉

Reposting as one week left for early bird registration and to get your abstract in!!

Vaccine-induced immune thrombocytopenia and thrombosis occurs in persons with Ig light-chain allele IGLV3-21*02 or *03 that recognizes a specific epitope on the adenoviral core protein pVII, resulting in misdirection of antibody targeting PF4 @nejm.org
www.nejm.org/doi/full/10....

The sneeze secret: how much should you worry about this explosive reflex? It is one of the most powerful involuntary actions the human body can perform. But is a big sneeze a sign of illness, pollution or something else entirely?

Prof Sheena Cruickshank @sheencr.bsky.social offers insight in The Guardian @theguardian.com on the science behind sneezing and what it reveals about our health #ImmunoSky

www.theguardian.com/society/2026...

You still have time to apply if you are interested in joining my lab!!

Been on multiple search committees

For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read

Huge thanks to sponsors Thistle Scientific Milltenyi @biologists.bsky.social Ludger

Very excited to announce that registration is open for the BSMB Spring 2026 meeting in Manchester, April 13-14th. Already an amazing lineup and lots of opportunities to speak!
Register, bsmb.ac.uk/meetings/ecm... @mcrcellmatrix.bsky.social

Introducing the amazing Dr Lily Koumbas Foley 🥰📚👩‍🎓 @crgglasgow.bsky.social @uofgsii.bsky.social

British Society for Immunology MIG seminar, Dr Alex Clarke, University of Oxford: “Powering the germinal centre reaction" Thursday 5th February 12 pm Michael Smith Lecture Theatre Lydia Becker Institute of Immunology and Inflammation

Dr Alexander Clarke @ajclarke.bsky.social joins us from
@ox.ac.uk tomorrow to give a talk entitled:

“Powering the germinal centre reaction"

📆 Thursday 5th Feb
🕛 12:00 PM
📍 Michael Smith Lecture Theatre

@britsocimm.bsky.social MIG Seminar #ImmunoSky

Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology.

For more info 👇
sheffield.ac.uk/biosciences/...

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...

CELL MIGRATION LAB We study cell migration in health and disease

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶

Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime