Join us Thursday, April 23rd, from 11:00-12:00pm for Marc Hellerstein's seminar titled "Advances in Metabolic and Protein Fluxes and Fluxomics: Translation to Human Disease" #seminarseries

a man says " you keep using that word i do not think it means what you think it means " to another bald man Alt: a man says " you keep using that word i do not think it means what you think it means " to another bald man

Forever relevant, especially for many of the high impact pubs

As some of you may know... we're down $5m and may or may not ever claw any of it back. So, we're writing new grants.

If anyone would be willing to share a funded application for
- NSF CAREER or NIH DP2 that is 100% dry lab-based
- NSF BIO Capacity: Infrastructure

I will owe you a coffee forever!

Join us for Jess Davidson's Ph.D. thesis defense on April 16! Davidson's research in the @judisimcox.bsky.social Lab explored how lipids are regulated under conditions of metabolic stress, such as cold exposure and disease. Learn more: ipib.wisc.edu/2026/03/30/i...

Acting on the advice of others: focus on illuminating tradeoffs and not on (others') outcomes Why advice based on success stories shields you from the real decisions that matter.

I love this essay by @jasonmfletcher.bsky.social

I try to be very honest with students about some of the many (MANY) “lottery-winning” moments in my career trajectory.

Here’s just one:

1/

a furry animal with yellow eyes is laying on a rock ALT: a furry animal with yellow eyes is laying on a rock

Dear Conference Organizers,

Please for the love of all things, provide an easily printable agenda. These weird web interfaces to build your own and apps are just not it. I'm sure you could find better ways to spend our conference fees. Maybe on more coffee? #AcademicSky

A star scientist showed that better genetics lessons could reduce racism. It was the death knell for his career Brian Donovan had persuaded high school teachers and education researchers that prejudice might be ended by changing how genetics is taught.

“We’ve lost out on the ability to continue to improve this work to make it more effective, and to explore how to apply it to other areas…There are a lot of different ways that genetics has been used to justify prejudice and…that human-made social categories interface with biological categories“🧪

In case anyone doesn’t know why, there are varied positions held within CSR. SROs disagree with each other and with management. Policy is argued. Ppl need support for their positions. So we need to be loud and constant for the ones who think as we do.

NIH watchers, you will be mostly unsurprised to see that the triage line will continue at ~one third past the first two rounds that were promised. I seen credible intel on that recently. In context that suggests this will be permanent. Ie CSR loves the results and the honoraria cost savings.

🎉 Congrats to 2026 Thomas Hunt Morgan Medal recipient Judith Kimble of @uwbiochem.bsky.social! Her work has built an entire field and inspired generations of scientists through her mentorship and leadership.

🔗Read more: buff.ly/0yzHXvk

CSR has already been broken. Advisory Committee disbanded (members included Donna Ginther), Noni Byrnes gone, chaos from delayed reviews. The death of expertise proceeds anon. It seems clear the "leadership" isn't interested in scientific review.

It is very cool to see this piece from a former student of mine, @mnicolen.bsky.social, in Nature's Career Feature section:

www.nature.com/articles/d41...

ASBMB staff Lynn Marquis, Raechel McKinley and Shannon Freedman pose for a photo with ASBMB committee members, fellows, delegates from the Advocacy Training Program and other ASBMB members in front of the U.S. Capitol building in Washington, D.C.

On March 6, ASBMB members convened in Washington, D.C., for the society’s Capitol Hill Day. They met with lawmakers & staff to call for increased federal investment in basic science via strong funding for the agencies that power U.S. scientific innovation.
www.asbmb.org/asbmb-... #ScienceServesUsAll

Our newest paper is out online!

An Open-Source Code to Analyze Mitochondrial Intracellular Distribution from Fluorescence Microscopy Images

Congrats @giologia.bsky.social!

portlandpress.com/bioscirep/ar...

🚨 excited to share our latest preprint on bioRxiv, led by the soon-to-be Dr. Guy Kunzmann!

We tackle a striking case of conditional dependence on UFMylation, a UBL modification pathway whose contributions to cell fitness have been a bit of a "black box." 🧵

We built the first complete genome for the common marmoset, fully resolving regions that were previously missing: centromeres, acrocentric short arms, and more. A new reference genome for anyone working with marmosets. This was an awesome collaborative effort & I’m grateful to all my co-authors! 🧬

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

still better when its fresh from the source though 😉

1/ Hot take: deep learning is overkill for 90% of bioinformatics problems.

I've watched teams spend months building neural networks that get outperformed by XGBoost trained in an afternoon.

Here's why simpler models keep winning.

I think it's simultaneously this and the fact that many enthusiasts seem to have a narrow sense of what job tasks are/can look like. There's a lot of "you don't understand what AI can do" coming at some of us and a legitimate response is "you don't understand what I can do, and need to, in my job."

Live-cell imaging of RNA dynamics using bright and stable fluorescent RNAs Nature Protocols, Published online: 20 March 2026; doi:10.1038/s41596-026-01343-zThis protocol provides guidelines for using fluorescent RNAs, entities consisting of an RNA aptamer bound to its cognate fluorogenic dye, for live imaging of the localization and dynamics of different RNA species in bacteria and mammalian cells.

New Article! Live-cell imaging of RNA dynamics using bright and stable fluorescent RNAs

Fundamental research powers innovation. FASEB advocates are urging Congress to provide $11.89 billion for #NSF in FY 2027 to support groundbreaking research across STEMM. Learn more: buff.ly/c0y1Z9h #FASEBOnTheHill

Investing in research = investing in our nation’s health. FASEB scientists and advocates are calling on Congress to provide $51.3 billion for #NIH in FY 2027 to advance biomedical discoveries and support the next generation of scientists. Learn why this investment matters: buff.ly/c0y1Z9h

Despite Congress’s bipartisan support, funding for scientific research has not kept pace with scientific opportunity, risking our nation’s competitiveness. Check out our recommended FY 2027 funding levels for federal research agencies. buff.ly/c0y1Z9h #FASEBOnTheHill

Nice shout out for the @dogagingproject.bsky.social - lovely paper in GSA Journals of Gerontology from the DAP crew @academic.oup.com

Jeff Coller, RNA biology professor at Johns Hopkins University, says federal maneuvering on messenger RNA (mRNA) has forced companies to "shelve promising potential therapies" and is having a "chilling effect on the research ecosystem."

Answering the Arguments Against Publicly Funded Biomedical Science in the United States In recent months, as National Institutes of Health (NIH) advisory councils have been depleted, thousands of federal scientists have departed, and research capacity has contracted, I’ve heard the same ...

open.substack.com/pub/elizabet...

Dogs and humans share biomarkers of mortality Abstract. There is growing interest in the use of molecular features as predictors of age, age-related disease risk and mortality. A major shortcoming of t

Happy to share our new paper from
the #dogagingproject. academic.oup.com/biomedgeront...
It turns out that metabolite predictors of mortality in dogs overlap significantly with those in humans.

@smacklab.bsky.social

Do metabolic fluxes change with age? Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.

Online Now: Do metabolic fluxes change with age? #trends #endocrinology #metabolism