Thank you, for the encouragement. Yes, dosage compensation levels are on a spectrum. In the topmost panel you will see on the left male germ cells where the dosage compensation is very low and on the right there are neuronal cells where compensation is very high. Other cell types fall in between.

Thank you for your encouragement. We were surprised by this finding as well, and it merits further detailed exploration.

👥 𝗧𝗮𝗴𝗴𝗶𝗻𝗴 𝗳𝗲𝘄 𝗹𝗲𝗮𝗱𝗲𝗿𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗲𝗹𝗱 𝘄𝗵𝗼 𝗺𝗮𝘆 𝗳𝗶𝗻𝗱 𝘁𝗵𝗶𝘀 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝗶𝗻𝗴 & 𝘄𝗵𝗼𝘀𝗲 𝘄𝗼𝗿𝗸 𝗶𝗻𝘀𝗽𝗶𝗿𝗲𝗱 𝗼𝘂𝗿𝘀: @ercanlab.bsky.social @sexchrlab.bsky.social @montserrat-anguera.bsky.social @irenemiguel-aliaga.bsky.social @adrianabriscoe.bsky.social @kaessmannlab.bsky.social @shihcheng.bsky.social @avrami.bsky.social

(5/5) Why revisit it now?
MicroPublications make focused results citable, open, and reusable.
If you work on dosage compensation, chromatin, genomics, or Drosophila, take a look 👇
🔗 doi.org/10.17912/mic...
#Drosophila #DosageCompensation #OpenScience

(4/5) Patterns emerged:
• Male reproductive cells → lower compensation
• Neural cells → higher compensation
• Other cells → normal compensation
Known regulators (RoX1 & RoX2) were involved—but couldn’t explain everything.
More biology to uncover 🔍

(3/5) What we found:
X-chromosome regulation spans a spectrum across cell types.
Some cells show lower activity, some are well balanced, and others show higher-than-expected activity.
Not a simple on/off switch.

(2/5) One year ago, we published a microPublication:
“Cell-Type Specific Variation in X-Chromosome Dosage Compensation in Drosophila.”
A short, peer-reviewed study showing X-chromosome regulation isn’t one-size-fits-all. doi.org/10.17912/mic...

(1/5) 🧬 Different organisms solve sex chromosome imbalance in different ways.
* In humans, females turn one X down
* In Drosophila, males turn their single X up.
Same goal: balanced gene expression.

But here’s the interesting question: does this balancing act work the same way in every cell type? 🤔

Prototyping #rshiny apps to native #electron desktop apps:

shinyelectron::export() → #rshinylive conversion → .dmg → Native Mac app

Zero #rstats dependencies for end users! Early days but promising 👀

Using FlyCellAtlas+experiments, we reveal how organs scale via cell size/number diffs: bigger female flight muscles from more myoblasts, larger hearts from bigger cardiomyocytes, & fat body tweaks. Allometric Framework for sex diffs in growth!

#Drosophila #SSD #Allometry #Preprint

Cell type specific allometry controls sex-differences in Drosophila body size Species and sex-specific differences in organ size are fundamental features of animal biology, yet the mechanisms that drive these differences remain debated. Adult female Drosophila are larger than m...

Excited to share our new preprint on bioRxiv: "Cell type specific allometry controls sex-differences in Drosophila body size"!

www.biorxiv.org/content/10.1...

𝗛𝗮𝘃𝗲 𝘆𝗼𝘂 𝗲𝘃𝗲𝗿 𝘄𝗼𝗻𝗱𝗲𝗿𝗲𝗱 𝗵𝗼𝘄 𝗺𝗮𝗹𝗲𝘀 𝗶𝗻 𝘀𝗼𝗺𝗲 𝘀𝗽𝗲𝗰𝗶𝗲𝘀 𝗹𝗶𝗸𝗲 𝗵𝘂𝗺𝗮𝗻 𝗮𝗿𝗲 𝗯𝗶𝗴𝗴𝗲𝗿 𝘁𝗵𝗮𝗻 𝗳𝗲𝗺𝗮𝗹𝗲𝘀 𝗲𝘃𝗲𝗻 𝘄𝗵𝗲𝗻 𝘄𝗲 𝗲𝘅𝗰𝗹𝘂𝗱𝗲 𝘁𝗵𝗲 𝘀𝗲𝘅-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗼𝗿𝗴𝗮𝗻𝘀? 𝗜𝘀 𝗶𝘁 𝗯𝗲𝗰𝗮𝘂𝘀𝗲 𝗼𝗳 𝗯𝗶𝗴𝗴𝗲𝗿 𝗰𝗲𝗹𝗹𝘀 𝗶𝗻 𝗺𝗮𝗹𝗲𝘀, 𝗼𝗿 𝗺𝗮𝗹𝗲𝘀 𝗵𝗮𝘃𝗲 𝗺𝗼𝗿𝗲 𝗰𝗲𝗹𝗹𝘀, 𝗼𝗿 𝗰𝗼𝗺𝗯𝗶𝗻𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝗯𝗼𝘁𝗵? 𝗗𝗼 𝗮𝗹𝗹 𝗼𝗿𝗴𝗮𝗻𝘀 𝗳𝗼𝗹𝗹𝗼𝘄 𝘁𝗵𝗲 𝘀𝗮𝗺𝗲 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝘆?