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Posts by Christian Diener

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Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests journals.plos.org/ploscompbiol...

1 day ago 106 47 1 0
Dynamics of phage-host interactions in Bacteroides fragilis resolved by single-cell transcriptomics - Nature Communications Phage-bacteria interactions are typically studied in bulk culture, which obscures cell-cell differences. Here the authors study phage-bacteria interactions using single-cell transcriptomics, identifyi...

Paper out: Profiling of lytic phage infection in individual B. fragilis cells with bacterial scRNA-seq. Congratulations Anika Gupta, Norma Morella, @monochamussutor.bsky.social Dmitry Sutormin et al, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.nature.com/articles/s41...

3 weeks ago 13 7 0 1
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Mikrobiom: Hype oder klinische Evidenz? Am 20.05.2026 bietet die Fortbildung „Medizinische Mikrobiomforschung“ fundierte Einordnung, organsiert von @medunigraz.at, JKULinz & @fwf-at.bsky.social CoE MicroPlanet
Aktuelle Forschung, Evidenzlage zu Diagnostik, FMT, Probiotika.

1 month ago 4 1 1 0
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Gut bacteria ammonia production restores acetylcholine neurotransmission and bowel motility Nature Microbiology, Published online: 26 February 2026; doi:10.1038/s41564-026-02292-9Acetylcholine levels are reduced in gut dysmotility conditions. We find that gut acetylcholine levels induce a compensatory increase in gut microbiota urease activity and ammonia production. By upregulating presynaptic Cav2.1 calcium channels in enteric neurons, ammonia enhances calcium influx and restores acetylcholine release neurotransmission, revealing a microbiota-driven mechanism that preserves gut motility.

Out Now! Gut bacteria ammonia production restores acetylcholine neurotransmission and bowel motility #MicroSky

1 month ago 8 3 0 0
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Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials Prebiotic and probiotic interventions can induce therapeutically relevant shifts in the human microbiome, but their effects are variable across individuals. This study shows that metabolic models can ...

Our latest is out today in @plosbiology.org:

"Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials"

@isbscience.org @uwbioe.bsky.social @uwgenome.bsky.social

doi.org/10.1371/jour...

1 month ago 40 19 2 0
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Integration of modern technologies to advance dietary assessment Nature Food - Accurately measuring dietary intake has long been a challenge in nutrition research. Integrating emerging tools with multisampling strategies and a dietary assessment methodology...

I joined efforts with D.A. Lucassen, @cdiener.com @gibbological.bsky.social and T. Wilson and got a really nice paper out on how to best integrate modern dietary assessment technologies to improve the accuracy of the current tools. Have a look here 👇 www.nature.com/articles/s43...

2 months ago 4 6 1 0
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Integration of modern technologies to advance dietary assessment - Nature Food Accurately measuring dietary intake has long been a challenge in nutrition research. Integrating emerging tools with multisampling strategies and a dietary assessment methodology aligned with the rese...

Check out our review on emerging technologies for diet tracking in Nature Food. 👇

This paper was led by @catalinacuparencu.bsky.social, with @cdiener.com and others: www.nature.com/articles/s43...

@isbscience.org @uwbioe.bsky.social @uwgenome.bsky.social

2 months ago 14 8 0 0
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How do we really assess dietary intake—and where is the field heading next?
This is the topic of the keynote lecture at #GMFH2026 by Lawrence David.

👉 Register now & join us www.gutmicrobiotaforhealth.com/porto-2026-fourteenth-ed...
📍Porto | March 14–15

2 months ago 2 1 0 0
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In remembrance of Peer Bork  | EMBL EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General. 

We mourn the passing of Peer Bork, EMBO Member since 2000: www.embl.org/news/embl-announcements/...

2 months ago 88 36 5 4
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So happy to host Dr. Xiaoqian (Annie) Yu - soon starting her lab at University of Montreal! She used population genomics and large data analysis to group gut microbiome into ecological units based on sweep events (major revision at Nature)!
www.biorxiv.org/content/10.1... #microsky #microbiomesky 🧪🦠

2 months ago 16 1 1 2
LinkedIn This link will take you to a page that’s not on LinkedIn

📢 We are hiring 📢 1st round of recruiting for our ERC project BacImmune-Decode! @erc.europa.eu
We are looking for a postdoc for wet-lab work on regulation of phage defence systems in bacteria using high-throughput microbial genetics. Check it out: lnkd.in/es7AE968
#Hiring #Postdoc #Microbiology

2 months ago 15 22 0 0

Apply now: 1 Postdoc + 1 PhD position, Anderson-Wagner group @univie.ac.at Focus: gut microbial effects on hippocampus & memory 🧠🦠

#PostdocJobs #Microbiome #AcademicJobs #PhDposition

Postdoc Ad: careers.univie.ac.at/en/postdoc/e... > Psychology
PhD Ad: careers.univie.ac.at/en/praedoc/p... > CoBeNe

3 months ago 22 13 2 0
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📢 Our Q1 2026 Newsletter is live!

Get the latest project updates, community news, and insights from the NFDI4Microbiota ecosystem.
👉 Read here: nfdi4microbiota.de/newsroom/new...

📬 Don’t miss future updates—subscribe to our mailing list: lists.nfdi.de/postorius/li...

3 months ago 3 2 0 0
Quadram Institute

Are you interested in #metaproteomics? We have a senior scientist position in my lab focused on metaproteomics, and xenobiotic- #microbiome -host interactions. Check it out.
jobs.quadram.ac.uk/Details.asp?...

3 months ago 6 6 0 0
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I am very excited to announce that a fully funded PhD position is available in my group.

Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia

Please RT or forward this information to interested candidates.

Deadline: 11.01.26

More info:

shorturl.at/f1TuF

4 months ago 52 67 0 2

📢 20 postdoctoral positions (full-time, 4 years) for outstanding female scientists 👩‍🔬 🔬 @univie.ac.at

The E-STEEM programme call opens January 7th, 2026 and closes March 3rd, 2026.
careers.univie.ac.at/en/postdoc/e...

I participate as a host...

3 months ago 15 15 1 1
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Open postdoc position!🚨 Passionate about gut microbes 🦠 and the brain 🧠? We are an interdisciplinary group at the Faculty of Psychology & @cemess.bsky.social 🌍 @univie.ac.at and invite individuals who self-identify as female. Details: 4 years, full-time ➡️ careers.univie.ac.at/en/postdoc/e...

3 months ago 16 12 1 0
Poster advertising doctoral positions in 2026 at the International Max Planck Research School for Evolutionary Biology.

Poster advertising doctoral positions in 2026 at the International Max Planck Research School for Evolutionary Biology.

Up to 10 doctoral positions at the Max Planck Institute for Evolutionary Biology now open for application!

Start date September 2026.

More info here: www.evolbio.mpg.de/imprs

3 months ago 14 22 0 0
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Metagenomic estimation of dietary intake from human stool - Nature Metabolism Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.

Top #Citations 2025: 9️⃣🧪

@cdiener.com @gibbological.bsky.social et al ( @isbscience.org @medunigraz.at ) present a new method to estimate dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.

3 months ago 12 5 1 1
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📢 New preprint on bioRxiv!

We introduce V4-EXT, a revised 16S rRNA V4 primer set that dramatically improves detection of Patescibacteria and other undersampled lineages

✅ 938 samples
✅ More novel ASVs

Primer choice matters 👀

www.biorxiv.org/content/10.1...

@ppjevac.bsky.social #HuifengHu

4 months ago 34 18 0 1

🧑‍💻 Need help with #nfcore #nextflow #bioinformatics pipelines, running or developing?

We are merging the 🌍 Eur/M.E./Afr and the 🌎 Americas weekly helpdesk.

Please join our host @vagkaratzas.bsky.social, nf-core maintainer, this Thursday at 14:30 CET | 08:30 ET on play.workadventu.re/@/nf-core/nf...

4 months ago 3 2 0 0
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Career Opportunities at the University of Hawai'i | University of Hawai'i

Come be my colleague at University of Hawaiʻi at Mānoa. We're hiring an assistant professor in Ocean Biogeochemical Modeling. 🌊

4 months ago 78 45 1 0
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2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB) Symposium Schedule All presentation times are shown in Pacific Daylight Time (GMT -07:00 / UTC -07:00) Time Talk / Session 9:00 Welcoming remarks by Sid Venkatesh Session One: Neural Effects

📣 Join us for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".

co-director - @flash-point.bsky.social 🦠💥

It's free, & we have an amazing line-up of speakers!

Dec. 12th. Please share!

isbscience.org/2025-isb-vir...

4 months ago 23 16 0 1
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Winter Summit 2025 | The Future of Microbiome Future of the Microbiome2025 Winter Summit Join us November 18-20, 2025! REGISTER NOW The Future of the Microbiome Winter Summit explores what’s next for the microbiome industry, bringing together bri...

Dr. Nick Quinn-Bohmann will present a Keynote Talk at this year's Future of the Microbiome Winter Summit (Nov. 18-20).

He'll talk about his work on using community-scale metabolic modeling to design personalized, microbiome-informed interventions. futureofmicrobiome.com/winter-summi...

4 months ago 7 4 0 0
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Less than a week remains to apply to this exciting PhD position and join my team at Osnabrück University 👇

5 months ago 10 9 2 0
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🧬 🦠 🏙️
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?

Excited to share our new paper: www.biorxiv.org/content/10.1...

5 months ago 36 12 2 0

LorBin: efficient binning of long-read metagenomes by multiscale adaptive clustering and evaluation. #LongRead #Metagenomics #MAGs #BinningMethods #UnsupervisedBinning @natcomms.nature.com
www.nature.com/articles/s41...

5 months ago 3 1 0 0
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Metalog: curated and harmonised contextual data for global metagenomics samples Abstract. Metagenomic sequencing enables the in-depth study of microbes and their functions in humans, animals, and the environment. While sequencing data

Great to see this finally published!

Metalog: curated and harmonised contextual data for global metagenomics samples

now out in @narjournal.bsky.social

academic.oup.com/nar/advance-...

5 months ago 57 38 1 2
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Untargeted longitudinal ultra deep metagenomic sequencing of wastewater provides a comprehensive readout of expected and unexpected viral pathogens Wastewater surveillance has become a powerful tool to monitor circulating viruses at a community level. Currently, most wastewater surveillance efforts use target-based approaches such as quantitative...

Can you take a quarter cup of composite sewage, simply ask ‘what’s in there?’, and find out all of the pathogens circulating in that community?

That is the question we asked in our latest pre-print.

Turns out you can.
1/
www.medrxiv.org/content/10.1...

5 months ago 118 36 6 5
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Distinguishing diet- and microbe-derived metabolites in the human gut - Microbiome Background Human gut microbes metabolize food and host secretions, consuming and producing small molecules that are important to health and homeostasis. Here, we present an atlas of diet- and microbio...

Looks interesting 👀: Distinguishing diet- and microbe-derived metabolites in the human gut microbiomejournal.biomedcentral.com/articles/10....

5 months ago 33 9 1 0