Want to annotate a bacterial genome with structures?

@oschwengers.bsky.social bakta and @gbouras13.bsky.social phold got together, and the result is Baktfold: protein annotation across the microbial tree of life using structures

www.biorxiv.org/content/10.6...

#phagesky #microsky #microbiomesky

#Daphnia #limnology #plankton #freshwater #hostmicrobiota #hostmicrobe #microbialecology #symbiosis #microbeinteractions #hostmicrobeecology @microbiomevif.bsky.social #holobiont #SymbioSky #MicroSky #microbiomesky #Microbiology @hostmicrobelit.bsky.social

Human systemic and mucosal immune responses support further exploration of a Klebsiella pneumoniae protein-based vaccine Neonatal sepsis caused by Klebsiella pneumoniae is a major cause of under-five mortality in sub-Saharan Africa, and the rapid increase of infections caused by bacteria resistant to most or all availab...

News from the #Klebsiella world! #Protein #vaccine targets might be worth a look... Human systemic and mucosal immune responses support further exploration of a Klebsiella pneumoniae protein-based vaccine. 💻🧬
#MicroSky #IDSky #MicrobiomeSky #AMR #MedSky #GlobalHealth
www.medrxiv.org/content/10.6...

#microSky #MicrobiomeSky

Hoho… @contamclub.bsky.social
#MicroSky #microbiomesky

At @uti-revisited.bsky.social we collect the findings of the UTIr project - on the ecology and evolution of recurrent urinary tract infections.

Interested in UTIs, pathogenesis, AMR, urobiome, microbial ecology & evolution?

Give us a follow!

#UTISky #AMR #microbiomesky
#microSky #evoSky #mevoSky

Sulfoquinovose degradation by cow rumen microbiota Abstract. Sulfoquinovose, a sulfonated sugar derived from the thylakoid membrane lipid sulfoquinovosyl diacylglycerol, is abundant in photosynthetic organi

📢 New paper 🚨

☘️🌿🌱🐄💨🦠🔬🧫🧬

#sulfoquinovose #microbiome

#microsky #microbiomesky

academic.oup.com/ismej/articl...

Apply now if you want to become a Master of Microbiomes! 🧙🧙‍♀️🪄🦠🧫🔬 #microbiomesky

Diet–microbiome associations in 10,068 individuals from the Human Phenotype Project to guide personalized nutrition - Nature Medicine Analyses of more than 10,000 participants from the Human Phenotype Project revealed distinct, persistent food–microbiome associations that can be used to simulate personalized dietary interventions to...

#NatMicroPicks

Diet-microbiome analysis at population scale 💻🦠

Diet shaped gut microbiome composition and function analysed at species-level resolution might enabling long‑term predictions and personalized dietary intervention strategies.

#MicroSky #MicrobiomeSky

www.nature.com/articles/s41...

Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma Zhou et al. reveal that gut L. salivarius and its metabolite indole-3-lactic acid (ILA) drive anti-PD-1 resistance in ESCC. Mechanistically, ILA activates AhR to suppress NF-κB signaling, triggering t...

#NatMicroPicks

Microbial factor in cancer immunotherapy resistance 🦀🦠💉

Ligilactobacillus salivarius–derived indole-3-lactic acid suppresses anti-tumor T‑cell populations, driving resistance to anti‑PD‑1 therapy in ESCC

#MicroSky #CancerSky #MicrobiomeSky

www.cell.com/cell-host-mi...

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids - Nature Microbiology Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of c...

#microsky #microbiomesky #microbiome

From Chris Stewart’s lab with a sialic acid twist

www.nature.com/articles/s41...

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals - Nature Medicine Using individual-level data from the Swedish Prescribed Drug Register and fecal metagenomes of 14,979 individuals in Sweden, the authors examined the association between oral antibiotic use over 8 yea...

#NatMicroPicks

Antibiotics in the long run ⌛💊🦠

Antibiotic use shows lasting associations with reduced gut microbial diversity for up to 8 years, indicating long-term impacts on the adult gut microbiome.

#MicroSky #MicrobiomeSky

www.nature.com/articles/s41...

The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, co...

#NatMicroPicks

A Microbial Atlas 🦠🗺️

MicrobeAtlas unifies >2 million microbiome samples into a resource that enables consistent cross‑study comparisons and ecological contextualization of both known and newly discovered species.

#MicroSky #MicrobiomeSky

www.cell.com/cell/fulltex...

#microSky #mevoSky #MicrobiomeSky #microbiome #synbio #biotechnology

This was great work by numerous people, in particular by @roxymzh.bsky.social . Many thanks to @fwf-at.bsky.social for supporting this work. @microbesplanet.bsky.social #archaeasky #microbiomesky

Join our next Policy Spotlight journal webinar for advice on how to maximise your impact in policymaking! This event is free to attend, register now!
#microsky #microbiomesky #ArchaeaSky #PhageSky

As a final note, I want to highlight that this approach is not restricted to #rRNA genes, but can be used for any amplicons used for microbial and #eDNA profiling! 🦠🧫🧬🪱🐛🐸🐟
#microsky #microbiomesky #protistsonsky

Baby-to-baby strain transmission shapes the developing gut microbiome - Nature A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...

Babies sharing microbes is a leading factor in gut development! A study across infants, educators, and families finds extensive transmission between babies during the first nursery year - early social interactions greatly shape their microbiome!
www.nature.com/articles/s41...
🧪🦠 #microbiomesky

An Engineered Variant of E. coli Nissle 1917 with Enhanced Transformation Efficiency and Robustness The gut microbiome and its effects on human health have generated considerable scientific, veterinary, and medical interest in recent years. Several gut bacterial species have emerged as potential cha...

#microsky #synbiosky #microbiomesky

pubs.acs.org/doi/10.1021/...

Subject collection cover with title: Microbiome in Health and Disease. A collection of papers, reprinted from Disease Models & Mechanisms

I'm excited to be heading to Wellcome Genome Campus next week for #Microbiome26 @eventswcs.bsky.social

Please come chat to me if you're interested in publishing with @dmmjournal.bsky.social & joining our microbiome collection of articles:
journals.biologists.com/dmm/collecti...

#MicrobiomeSky

Our new preprint introduces #kineochelins, a new group of #siderophores produced by the Antarctic soil actinomycete 🦠🔬🧫 #Actinokineospora sp. UV203

Kudos to the amazing Stanislava Králová & a fantastic team of collaborators 🤩
#microbiomesky

www.biorxiv.org/content/10.6...

Integrated Responses: Multi-dimensional Evidence of #Diet-#Microbiome Coupling of #Fish across a #River Continuum in a Dry-Hot Valley
#SymbioSky #MicroSky #microbiomesky @microbiomevif.bsky.social @superbugs.bsky.social @hostmicrobelit.bsky.social holobiontbiology.bsky.social
tinyurl.com/3buzfar5

From dysbiosis to longevity: a narrative review into the gut microbiome’s impact on aging - Journal of Biomedical Science Aging has become an important public health concern with the accelerated aging of the global population. The rising impetus to extend lifespan as well as healthspan has drawn attention to the gut microbiome, an indispensable yet modifiable determinant of the aging process. This narrative review addresses the complex interaction between the gut microbiome and aging, synthesizing findings in logical order. Evidence from model organisms supports the causal influence of gut microbes on host aging and longevity. Developmental evolution of the human gut microbiome throughout life stages reflects its adaptive nature affected by diet, lifestyle, hormone levels, and immune function, regulating aging through the gut-muscle and the gut-brain axes in late life. Signature characteristics of the long-lived gut microbiome, including increased diversity, elevated beneficial taxa, and enhanced gut homeostasis, lead to strategies to extend longevity. Intake of fiber, regular exercise, and pro-/pre-/postbiotic supplements are potential interventions on the gut microbiome to foster vitality in later years. Centering on these connected topics, this review identifies questions warranting investigation, with potential to improve therapeutic strategies for healthy aging.

A Review in the Journal of Biomedical Science examines key themes related to the gut microbiome and aging, its progression across the lifespan from infancy to adulthood and old age, and potential interventions targeting the microbiome to address aging-related changes.

#MedSky #MicrobiomeSky

The AMI Journals are excited to join Bluesky! Follow us at
@ami-journals.bsky.social to keep up to date with the latest news and articles! #microsky #microbiomesky

Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design A global genomic survey of infant gut bifidobacteria shows that B. infantis remains highly prevalent and diverse in infants from low- and middle-income countries but scarce in Western, industrialized ...

Really nice study from Yan Shao, continuing his work on the infant gut microbiota. #microbiomesky

#microsky #microbiomesky #glycotime

Akkermansia FTW

www.biorxiv.org/content/10.6...

Profs. James Chong & Lindsay Hall will be delivering you their key insights on how to culture the unculturable direct from their many years of struggle with the “Dark matter” of the microbiome. Register here 🧪https://tinyurl.com/xr58eb28🧫

#Webinar #LabLife #MicrobiomeSky #ScienceSky

Synthetic microbial communities as novel models to study gut microbiome–host interactions in metabolic diseases - Discover Endocrinology and Metabolism Synthetic gut microbial communities (SynComs) have emerged as powerful platforms for investigating microbiome–host interactions in metabolic diseases. By enabling precise control over microbial composition, SynComs overcome key limitations of traditional models, such as ecological variability, low reproducibility, and limited mechanistic resolution. Most current SynComs focus on bacterial consortia, although interest in fungal and mixed communities is growing. These defined consortia have been successfully applied to reproduce disease-relevant phenotypes; elucidate microbial contributions to obesity, insulin resistance, and hepatic lipid metabolism; and identify specific taxa or strain-level functions with therapeutic potential. Their versatility spans in vitro systems—including batch fermenters and gut-on-chip devices—as well as in vivo models such as germ-free or gnotobiotic mice. Moreover, the integration of multi-omics technologies and computational modeling has enhanced the predictive capacity and functional insight of studies employing SynComs as experimental models. Despite current challenges—such as reduced ecological complexity and translational gaps—ongoing innovations in microbial culturing, host-relevant model systems, and rational SynCom design are expanding their applicability. This review evaluates the construction, applications, and limitations of SynComs, highlighting their potential to advance microbiome-targeted research and therapeutic development in metabolic disorders.

A Review in Discover Endocrinology and Metabolism evaluates the applications, and limitations of synthetic microbial communities, highlighting their potential to advance microbiome-targeted research and therapeutic development in metabolic disorders.

#MedSky #MicrobiomeSky

Bringing the band back together: eukaryotic microbes in microbial genomics Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefi...

Hot off the press; an update from last year's conference on Microbial Genomics of Eukaryotes, highlights from our collection in MGen & tiny 2027 teaser 😊@fionahenriquez.bsky.social @microbiologysociety.org
#MicroSky #MicrobiomeSky #IDSky #Protistonsky 💻🧬
www.microbiologyresearch.org/content/jour...

Join us online for #Microbiome26!

Register for a virtual place by 23 February ➡️bit.ly/4kttBOX

Dip into interesting talks from leading scientists, clinicians and bioinformaticians working in #microbiology. 🦠

🗓️ Dates: 2-4 March 2026
Access through an easy online portal 🖥️
#MicrobiomeSky