Want to annotate a bacterial genome with structures?

@oschwengers.bsky.social bakta and @gbouras13.bsky.social phold got together, and the result is Baktfold: protein annotation across the microbial tree of life using structures

www.biorxiv.org/content/10.6...

#phagesky #microsky #microbiomesky

Our perspective on measuring individual virus traits, led by staff scientist @antanij.bsky.social
#phagesky #microsky

Rage against the mean: a perspective on measuring fitness of individual phage particles - npj Viruses npj Viruses - Rage against the mean: a perspective on measuring fitness of individual phage particles

@paulturnerlab.bsky.social and I wrote a perspective on the need and recently developed approaches to study individual virus traits in the most numerous viruses on our planet (phages).

Let's move beyond measuring the mean #phagesky

www.nature.com/articles/s44...

#microsky #virology #microscopy

A family of endonucleases blocks nanotube-mediated plasmid exchange - Nature Microbiology The YokF endonuclease provides a donor-controlled mechanism to limit plasmid transfer to recipient bacteria via nanotubes in Bacillus subtilis, with YokF functional homologues found across Gram-positi...

#microsky #phagesky #MGE

A prophage-encoded endonuclease blocks plasmid transfer between bacterial cells

www.nature.com/articles/s41...

Protein and genomic language models uncover the unexplored diversity of bacterial immunity The bacterial pangenome contains a vast diversity of antiphage systems, whose overall extent is still unknown. In this study, we developed complementary machine learning approaches to systematically p...

#microsky #phagesky #phage defence

www.science.org/doi/10.1126/...

a treasure trove for #PhageSky

#MicroSky #PhageSky

Arbitrium phages can manipulate each other’s lysis/lysogeny decisions Many viruses can switch between lytic replication and dormancy (or lysogeny). It was recently discovered that some viruses that infect bacteria (known…

www.sciencedirect.com/science/arti...
#phage #phagesky

The PhageExpressionAtlas just made it to bioRxiv. Visually explore the transcriptomes of phage-host interactions or harness the database for analysis across infections! Please leave feedback, which functionalities/data you find missing.
Preprint:
www.biorxiv.org/content/10.6...

#phagesky #microsky

Hey #Phagesky [Ph]ans! My first work with the Penadés lab is out! Come read how arbitrium-coding phages sense non-cognate Arbitrium signals from other phages to influence their lysis-lysogeny decisions. www.cell.com/cell/fulltex...

#microsky #phagesky

Temperate #phage better than lytic at infecting E. coli biofilms

journals.plos.org/plosbiology/...

#phage #phagesky

#PhageSky

#microsky #phagesky on #phage cocktails

This data is important and this is a question we need to answer for phage therapy. We already know the answer for most small molecule antibiotics - they are less active in biofilm and other infectious milieus that have lower replication rates. It's a tough problem! #phagesky

#PhageSky

KlebClub program

🚨 Big news! 🚨

Here the FINAL 2026 Speaker list for our seminar series!!

✨ Get ready for:
• Pathogenesis session
• Pediatrics #Klebsiella
• Translational Microbiology
• #KlebClub Community Flash talks!

Starting April 9th - 9 AM EST!

#KlebClub2026 #microsky #UTIsky #phagesky
Registration is FREE

Tick talk: UK researcher targets Lyme disease with 2 grants Brian Stevenson, Ph.D., a professor in the College of Medicine’s Department of Microbiology, Immunology and Molecular Genetics and the Martin-Gatton College of Agriculture, Food and Environment’s Depa...

Tick talk: UK researcher targets Lyme disease with 2 grants

Nice when the university recognizes you! 😊

#MicroSky
#PhageSky

uknow.uky.edu/research/tic...

Another week, another paper that we liked so much, we made a brief comment on

You should take a look! It's only a short thread 🧵

#Phage #Phagesky

www.pnas.org/doi/10.1073/...

Phages drive the dissemination of antibiotic resistance genes by facilitating host adaptation to heavy metal stress

#phage #phagesky

We recently came across this study (published on @elife.bsky.social ) and it caught our eye, so we decided to make a brief #phagesky comment on it
📝Premise
✅What we liked
❓Questions it raised for us
elifesciences.org/reviewed-pre...

All images are taken from the paper

#PhageSky

Cross-order detection of bacteriophage transduction in microbial communities using RNA barcoding - Nature Communications Bacteriophages are the most abundant life form on earth and can be applied to eliminate or engineer bacteria. Here, authors demonstrate RNA barcoding as a high throughput tool to measure bacteriophage...

#microsky #phagesky #phage

www.nature.com/articles/s41...

#microsky #phagesky #MGE

Phage therapy in oncology: opportunities for cancer prevention and treatment Bacteriophages (phages) are emerging as programmable biological therapeutics in oncology, extending beyond their traditional antimicrobial applications. This review proposes a phage–microbiome–immune–...

Excited to share this review🔔, we spent sometime thinking about
phage–microbiome–immune–oncology axis for phage therapy in cancer!
#phage #phagesky
Phage therapy in oncology: opportunities for cancer prevention and treatment: Trends in Molecular Medicine www.cell.com/trends/molec...

We recently had a nice lab discussion about this work and wanted to share some of it on a short thread here 🧵

BTW, word on the street is that prophages are pretty cool 😎

#Phage #Phagesky

www.nature.com/articles/s41...

Capturing dynamic phage–pathogen coevolution by clinical surveillance - Nature The acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the subsequent evolution of ICP1 to escape this defense, are...

#microsky #phagesky #phage

www.nature.com/articles/s41...

Congrats to Caroline on a VERY nice thesis work!!!!

#phage #phagesky

#microsky #phagesky #phage

cc @vscooper.micropopbio.org @brockhurstlab.bsky.social @bramvandijk.bsky.social @bramvdbe.bsky.social @aharms485.bsky.social @annadragos.bsky.social @emmseveri.bsky.social @epcrocha.bsky.social @ellinoralseth.bsky.social @vivekmutalik.bsky.social @olayarendueles.bsky.social
#PhageSky