Odorant receptors from the jumping bristletail form homotetramers made up of four identical OR subunits. The OR5 channel, shown above (pdb_00007lic), opens upon binding a variety of odorant molecules, including eugenol (orange, pdb_00007lid) and DEET (green, pdb_00007lig).

The OR5 channel opens upon binding a variety of odorant molecules, including eugenol (orange) and DEET (green)
More at April's Molecule of the Month: pdb101.rcsb.org/motm...

Register for the April 23 Open Discussion–Deposition, Validation, and Biocuration Bring your questions about Deposition, Validation, and or Biocuration to this Office Hour. Biocurators will answer general questions about the process or about your specific entry or session.

Register for the April 23 Open Discussion–Deposition, Validation, and Biocuration
Bring your questions about Deposition, Validation, and or Biocuration.
Biocurators will answer general questions about the process or about your specific entry or session.

Self-synthesising RNA strand offers clues to life’s origins RNA strand, made of just 45 nucleotides, performs two key reactions required for self-replication

A strand of RNA has been discovered to perform two key reactions required for self-replication. The molecule offers a clue towards understanding the origin of life, namely how non-living chemistry on prebiotic Earth started to self-replicate and evolve.

Protein Design Principles Revealed in AI Analysis of Nanoribbon Assembly | News Release | PNNL An AI program called AtomAI helped PNNL researchers reveal key design principles for protein interfaces with mineral surfaces.

Protein Design Principles Revealed in AI Analysis of Nanoribbon Assembly
Thin water layer on mineral surface helps protein nanoribbons slide into place, as revealed by machine learning analysis of microscopy images

Annual Report Published Download the 2025 Annual Report for an overview of recent activities and how RCSB PDB supports the broad PDB user community with a wide range of resources understanding 3D biostructures

Download the 2025 Annual Report for an overview of recent activities and how RCSB PDB supports the broad PDB user community with a wide range of resources understanding 3D biostructures

PDB101: Register for the April 30 CodeBMB Webinar for Beginners PDB-101: Training, Outreach, and Education portal of RCSB PDB

April 30: Join us for an introduction to a pedagogical foundation for coding
- Understand how coding can contribute to student learning
- Recognize and write basic Python scripts
- Open and modify existing Colab notebooks to use in their courses.

RCSB PDB Quartely Newsletter | Spring 26 | Issue 109 This issue highlights new Advanced Search Features; the new Beta PDB Archive, and Mol* training videos

Our Spring Newsletter is out!
Highlights new Advanced Search Features; the new Beta PDB Archive; and Mol* training videos.
In the Education Corner, learn about An Online Book to Create and Teach Through Molecular Visualization

Register for the May 19 Webinar on Accessing RCSB PDB APIs with Python Learn how to use Python and the rcsb-api package to access Sequence and Model APIs

Register for the May 19 Webinar on Accessing RCSB PDB APIs with Python
Learn how to use Python and the rcsb-api package to access Sequence and Model APIs

PDB101: Molecule of the Month: Plastic-eating Enzymes Researchers are looking to Nature to find ways to dispose of discarded plastic.

PDB-101 is focused on #biotechnology and offers materials to explore how researchers are using biology in industry.
Learn how researchers are looking to Nature to find ways to dispose of discarded plastic.

Scientists pinpoint protein shapes that track Alzheimer’s progression
New findings from Scripps Research show that changes in protein shape—rather than quantity of proteins—offer a potential new way to detect and track Alzheimer’s disease.
www.scripps.edu/news...

Preparing for the next pandemic: scientists discover a new class of influenza antivirals Researchers from Leiden University, University of York, University of Barcelona/IQTCUB/ICREA and The Francis Crick Institute report a new class of experimental compounds that powerfully block influenza viruses. The findings offer a potential new strategy for treating flu infections and preparing for…

Scientists discover a new class of influenza antivirals
These compounds are inspired by the widely used flu drug Oseltamivir (Tamiflu), but are designed to act in a fundamentally different way.

Build Tabular Reports of PDB Data After searching for a set of structures, create summary and customizable tabular reports. Tables can be saved in CSV or JSON formats.

Build Tabular Reports of PDB Data
After searching for a set of structures, create summary and customizable tabular reports. Tables can be saved in CSV or JSON formats

RCSB PDB chatbot icon

RCSB PDB has launched a chatbot to answer general questions about structure deposition, biocuration, validation or PDB policies.
Try it today and rate the response: rcsb-deposit-help.rc...

Register for the May 14 Office Hour on the new AI-Powered 3D Structure Similarity Search Learn how this feature delivers faster and more scalable structural comparisons across experimentally determined PDB structures and predicted Computed Structure Models (CSMs).

Register for the May 14 Office Hour on RCSB PDB's AI-Powered 3D Structure Similarity Search
Learn how this new feature delivers faster and more scalable structural comparisons across PDB structures and predicted Computed Structure Models (CSMs).

PDB101: Learn: Flyers, Posters, & Calendars: Posters: Folding of Protein Domains This poster highlights common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme.

Download a Protein Domains Poster from PDB-101
This poster highlights common arrangements of secondary structure elements in protein domains as defined by CATH.

Take the survey to win a 4 x 6" canvas of Insulin Release, 2022 by David S. Goodsell.

RCSB PDB wants to learn how users are utilizing integrative (IHM) structures and Computed Structure Models (CSMs) at RCSB PDB.

Please take this brief survey: go.rutgers.edu/pqz9bucz

Respondents can enter into a drawing for a canvas featuring the artwork of David S. Goodsell.

Poster Prize Awarded at ASBMB Congratulations to Sara Scanlan (James Madison University) for The Structural Mechanism of Malate Dehydrogenases and Support for the Reciprocating Mechanism of Catalysis.

Poster Prize awarded at ASBMB. Congratulations to Sara Scanlan (James Madison University) for The Structural Mechanism of Malate Dehydrogenases and Support for the Reciprocating Mechanism of Catalysis.

PDB101: Molecule of the Month: Proteins and Biominerals Small biomineral crystals are used to build bone, eggshells and even tiny compasses.

You might be surprised to hear that tooth enamel, the strongest material in our body, and eggshells, which must be fragile enough for baby birds to hatch, are both roughly 95% composed of mineral crystals.

Engineered Microbes Pull Critical Minerals from Mining Waste Biomining uses engineered microbes to harvest critical minerals

Meet the Microbes That Munch Mountains of Mining Waste
Biomining uses engineered microbes to harvest critical minerals

Call for Targets: CASP17 (2026)
Depositors: Help advance the frontiers of structural biology by submitting your targets

Paper Published: Multi-scale structural similarity embedding search across entire proteomes
Learn about a scalable structural similarity search strategy designed to traverse enormous volumes of 3D biostructure data, including PDB structures and CSMs
academic.oup.com/bio...

The Critical Assessment of Structure Prediction (CASP) experiment is calling for prediction targets: Immune Complexes, Organic Ligand-Protein Complexes, Nucleic Acids and Complexes, Conformational Ensembles, Difficult Protein Structures and Complexes. Rule of Thumb: If AlphaFold3 can generate a high-quality model, it is likely not a CASP-grade challenge. If it struggles, we want it.

Is #AI hitting a plateau in structure prediction? Help us find out at CASP17! 🧪🧬

Calling for Targets: Immune Complexes, protein - ligand complexes, RNA/DNA, conformational ensembles, membrane proteins, viral origins, and large complexes.

The Rule of Thumb: If AF3 can’t model it, we want it.

PDB101: Molecule of the Month: Insect Odorant Receptors Protein complexes that allow insects to detect a wide variety of volatile compounds

April's Molecule of the Month: Insect Odorant Receptors
These protein complexes allow insects to detect a wide variety of volatile compounds, from clove oil to DEET

1.4K views · 12 reactions | "Ayacucho epicentro de la ciencia global:... "Ayacucho epicentro de la ciencia global: Con respaldo de instituciones que lideran la ciencia mundial, BILBB inaugura 'Habitar lo Invisible', la primera exhibición museográfica de arte científico...

Congratulations to BILBB in Ayacucho, Peru on the launch of their exhibition "Habitar lo Invisible" (Inhabiting the Invisible) featuring an impressive collection of #sciart images, including PDB structure illustrations

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Photos: www.facebook.com/sto...

PDB101: Register for the April 30 CodeBMB Webinar for Beginners PDB-101: Training, Outreach, and Education portal of RCSB PDB

Register for the April 30 CodeBMB Webinar for
- Scientists in the biosciences starting to code
- Post-docs and graduate students who want to bring coding into their learning
- Instructors involved in Biochemistry and Molecular Biology Education

First deposition of a structure determined at XAIRA XAIRA beamline reached another milestone, with the first deposition of a new macromolecular structure in the Protein Data Bank determined from diffraction data obtained at XAIRA. The deposition of the atomic structure of this protein complex represents an early result of the beamline’s recently launched user program, with many more structures expected to follow.

This finding establishes EPCR as a genuine receptor for FVIIa, overturns the view that EPCR is restricted to protein C/APC binding, and provides a structural explanation for how rFVIIa may influence protein C activation during haemophilia therapy.

Scientists develop molecules that may treat Crohn’s disease | Broad Institute The molecules mimic a gene variant that protects against Crohn’s, demonstrating a roadmap for using genetics to develop therapies for inflammatory bowel disease and other chronic inflammatory disorders.

The molecules mimic a gene variant that protects against Crohn’s, demonstrating a roadmap for using genetics to develop therapies for inflammatory bowel disease and other chronic inflammatory disorders.

Exploring Computed Structure Models (CSM) at RCSB.org RCSB.org offers access to PDB experimental structures, integrative structures, and Computed Structure Models (CSMs) from AlphaFold DB and ModelArchive. Learn how to use RCSB.org (https://www.rcsb.org/) features to navigate 3D predicted protein structures in the context of experimentally-determined

Watch the Exploring CSMs at RCSB PDB Office Hour
Learn how to use RCSB PDB features to navigate 3D Computed Structure Models from AlphaFold DB and ModelArchive

Use the AI-Powered 3D Structure Similarity Search This new feature delivers faster and more scalable structural comparisons across experimentally determined and predicted Computed Structure Models (CSMs).

Use the AI-Powered 3D Structure Similarity Search
This new RCSB PDB feature delivers faster and more scalable structural comparisons across experimentally determined and predicted Computed Structure Models (CSMs).

PDB101: Take the RCSB PDB Survey and Win PDB-101: Training, Outreach, and Education portal of RCSB PDB

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