Could we be heading towards a no-LHe-refill commercial NMRs in the next 30 years?
With these prices, better sooner than later

Researchers make ‘quantum cat’ video out of individual atoms Demo showcases new AI-powered tool of potential use in quantum computers

I’d call it the “true Schrödinger cat”
Researchers make ‘quantum cat’ video out of individual atoms | Science | AAAS www.science.org/content/arti...

My cat likes to watch anime in bed, so he’s a little otaku too

I do it every three months, but just now I realized how weird it is

This is seriously cool AF

cryogenic helium burns are funny, after a while it feels like everything you touch is hot. It has been 3 days since and counting

O rarely get excited or happy in behalf of others, but I’m pretty stoked that my friend got a scholarship to finish her work in biophysics in germany

Our new @chemrxiv.bsky.social preprint: AIMNet2-rxn: A #MachineLearning Potential for Generalized Reaction Modeling on a Millions-of-Pathways Scale! #compchem Collaboration with @profsavoie.bsky.social group. Funded by ONR under #MURI program. #chemsky chemrxiv.org/engage/chemr...

Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials - Nature Biotechnology A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials - @rothamsted.bsky.social @ox.ac.uk @rosfrankinst.bsky.social go.nature.com/4lQs4nC

From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck Necessity is the mother of invention. Most synthetic chemistry innovations are driven by our desire to make molecules. In the first half of the 20th century, much of this work was inspired by natural ...

One thing you can count on from me is to share great synthesis. While we may be competitors, I’ll highlight this review of #MerckChemistry innovations in #JOCasap from my respected industry colleague and friend @drlcsquare.bsky.social The work here is inspiring and drives us to our best #ChemSky

This is nice

Iron-catalysed direct coupling of organosodium compounds - Nature Synthesis Despite the abundance and non-toxic nature of sodium, organosodium reagents have rarely been used in organic synthesis. Now iron-catalysed homocoupling and C(sp2)–C(sp3) cross-coupling reactions of ar...

Now online & open access:

Article by Ikko Takahashi, Andreu Tortajada, David E. Anderson, Laurean Ilies, Eva Hevia & Sobi Asako

Iron-catalysed direct coupling of organosodium compounds

www.nature.com/articles/s44...
#ChemSky

Thanks! I'll give it a read

AI doesn’t know how to depict chemistry Serving the chemical, life science, and laboratory worlds

What happens when you ask genAI to draw caffeine? Some menacing and unexpected imagery, finds @rowanwalrath.bsky.social for #Newscripts in @cenmag.bsky.social
cen.acs.org/physical-che...

Anyone can recommend a good book or review on conformational dynamics, specially on the kinetics? Thermodynamics is also welcomed. #chemsky

My current position as a substitute professor doesn't allow me to have a lab or students to oversee, so any ideia I have to do it by myself on my freetime (not a lot).
I can't wait for a tenure track one so I can begin to stretch my legs.
SO MUCH stuff on glycochem and physchem!

Another classic case of… “how is that a drug?” organic chemist edition

Just wow...

I propose we delve too greedily and too deep

I can't wait to go see my cat-son again!

Helium day! @lipqlaremar.bsky.social

Nice!

Compound Interest: Do daffodils kill other flowers in vases? Spring is here, and daffodils are blooming. You might have some in your garden, or you might pick some up at a florist to put in a vase at home. If you do, it’s a good idea to place them in a…

There’s a great @compoundchem.com graphic on this very topic:

www.compoundchem.com/2018/03/23/d...

#Chemsky

Universal Reagent for Mild and Stereospecific Nucleophilic Substitution of Alcohols with Amines A user-friendly, shelf-stable protonated betaine reagent (BEHT triflate), derived from Mitsunobu reagents, has been developed to enable the direct displacement of alcohols using primary and secondary...

A major breakthrough for the Mitsunobu reaction! New work from the Charette lab at UMontreal reports a universal Mitsunobu reagent with no limitation on nucleophile pKa, expanding substrate scope to include primary & secondary amines that were previously incompatible with this reaction!

TIL (after nearly 50 years of being a chemist) that hydron is the formal IUPAC name for H+ #chemsky

Planar Chirality
@makingmolecules.com

The crappy side of being always at the knowledge area's interface is being always lost when things need to be a little more specific. Right now, suffering with statistics and physical chem (orginally a synthetic)

Higher Contrast in 1H‐Observed NMR Ligand Screening with the PEARLScreen Experiment For initial hit identification in fragment-based drug design, NMR is one of the preferred methods, with the well-established ligand screening experiments T1ρ, waterLOGSY and STD. Here, we present a n...

PEARLScreen Higher Contrast in 1H-Observed NMR Ligand Screening, Nils Lorz, Barbara Czarniecki, Sandra Loss, Benno Meier, Alvar D. Gossert* onlinelibrary.wiley.com/doi/abs/10.1... #NMRchat #NMR 🧲

13C pulse calibration on benchtop nmr is a pain. GOD

This kind of instrumentation boggles my mind