Another paper from our collaboration with Rob Britton’s lab! We’ve been focusing on novel methods to make nucleoside analogues for over 7 years now. This week we published our 2nd Science paper in the area. Congrats to the team! #MerckChemistry

www.science.org/doi/10.1126/...

Nice one Sue! #MerckChemistry

Dani and LC at the microphone

We are seeking questions from our audience of the Pharm-to-Table podcast. Dani & I will select the best questions for our annual tradition of kicking off our new season this way. What do you want to know about being a chemists in pharma? Let us know?!

#MerckChemistry

Reagent for the Chemoselective Reduction of Carboxylic Acids to Aldehydes We report the development of a multifunctional reagent for the direct conversion of carboxylic acids to aldehydes under mild conditions and with exquisite chemoselectivity. These reactions proceed in aqueous solvent at room temperature in 20 min, can be done open to air, require no metal catalysts, and employ near-stoichiometric amounts of both reducing agent and a mild base. No over-reduction, epimerization, or reduction of other reducible functional groups is observed. With this reagent, a broad scope of complex, drug-like aryl and alkyl carboxylic acids can be reduced directly to aldehydes.

Maloney and Fier at it again this time with a neat concept for a one-reagent acid to aldehyde reduction
#OrgLettASAP #MerckChemistry #ChemSky

Safety Letter: Evaluation of the Popular Oxidant 2-Iodoxybenzoic Acid (IBX) 2-Iodoxybenzoic acid (IBX) is a versatile oxidant used in chemical synthesis. It has been employed as a reagent in more than 1400 publications since its initial use as an oxidant described in 1994. Wh...

Excellent safety letter in #OrgLettAsap today from the Garg Lab (UCLA) and #MerckChemistry on the hazards of IBX - please read
And thank you to Org Lett for publishing this informative article
#ChemSky

Really proud of our team for their achievements in #GreenChemistry recognized by the ACS yesterday in D.C. Congrats to the islatravir team on their win! #MerckChemistry

IIRC I was down in Rahway NJ visiting some #MerckChemistry friends after I moved to CT and watched the Bronco chase in the Waiting Room pub on Main St (a fav Rahway hang out)

Also seeing a lot of full story med chem papers and less A-B then B-C series of papers
My time at #MerckChemistry (early 90s) big programs like A2 Antagonists with multiple series that each wrote a paper
2/n #ChemSky

Spring 25' saw the kick-off of our first #MerckChemistry Symposium at UW-Madison. We were blessed with beautiful weather and an amazing day of science. Special thanks to our hosts @tehshik.bsky.social & Shannon Stahl, Scott and Emma as Merck organizers, and the entire UW Chem and ChemEng community!

Shared Roots with Divergent Paths: Exploring Discovery R&D in Pharma and Agrochemistry - American Chemical Society Join us for a unique side-by-side comparison of the discovery, research, and development (R&D) processes that drive innovation in pharma and agrochemistry.

Join us on Wed May 14 @ 2 PM ET!
I'm excited to host the next @AmerChemSociety Webinar exploring the similarities between Pharma & Farm-a with speakers Nikki Goodwin #MerckChemistry (MedChem) and Tejas Shah @corteva (AgroChem) #ChemSky

Free sign up at link below

June 27 at Conn College New London CT #PfizerChemistry #MerckChemistry @boehringerus #BMSChemistry & @ACS_CVS are hosting the 7th Annual Symposium on Applied Synthesis featuring Ryan Shenvi (Scripps) & Martin Tomanik (NYU) Slots for student talks available #ChemSky https://www.cvs-acs.org/event-details/7th-annual-symposium-on-applied-synthesis

June 27 at Conn College New London CT #PfizerChemistry #MerckChemistry
@boehringerus #BMSChemistry & @ACS_CVS are hosting the 7th Annual Symposium on Applied Synthesis featuring Ryan Shenvi (Scripps) & Martin Tomanik (NYU)
Student talks available
#ChemSky Reg is open: www.cvs-acs.org/event-detail...

Director of Mass Spectrometry, AR&D Job Description The Analytical Enabling Capabilities Department has an exciting opportunity for a Director of Mass Spectrometry (MS). The MS Lead provides strategic and technical leadership for MS cap...

Director of Mass Spectrometry, AR&D #MerckChemistry #chemjobs The Analytical Enabling Capabilities Department in AR&D has an exciting opportunity in Mass Spectrometry: msd.wd5.myworkdayjobs.com/SearchJobs/j...

From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck Necessity is the mother of invention. Most synthetic chemistry innovations are driven by our desire to make molecules. In the first half of the 20th century, much of this work was inspired by natural ...

As a student, I was inspired to pursue a career in pharma by reading about the amazing synthetic chemistry innovations that were happening there.

I hope this article can do the same for the next generation of pharmaceutical chemists. #MerckChemistry

pubs.acs.org/doi/10.1021/...

From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck Necessity is the mother of invention. Most synthetic chemistry innovations are driven by our desire to make molecules. In the first half of the 20th century, much of this work was inspired by natural ...

One thing you can count on from me is to share great synthesis. While we may be competitors, I’ll highlight this review of #MerckChemistry innovations in #JOCasap from my respected industry colleague and friend @drlcsquare.bsky.social The work here is inspiring and drives us to our best #ChemSky

Canadian American chemist LC Campeau

Today at #ACSSpring2025 the ORGN @organicdivision.org is celebrating Canadian-American chemistry including @drlcsquare.bsky.social from #MerckChemistry speaking on the macrocyclic PCSK9 inhibitor MK-0616 #ChemSky

So honored to be selected for this award! [which included being notified with a phone call from Margaret Faul herself!] 💫

Looking forward to the ceremony and having a blast crushing more #MerckChemistry! 🙌🧪🕺

C–H Aminoalkylation of 5-Membered Heterocycles: Influence of Descriptors, Data Set Size, and Data Quality on the Predictiveness of Machine Learning Models and Expansion of the Substrate Space Beyond 1... We report a general C–H aminoalkylation of 5-membered heterocycles through a combined machine learning/experimental workflow. Our work describes previously unknown C–H functionalization reactivity and...

New from a #merckchemistry internal collaboration with Cyndi He and Stephanie Felten: ML and active learning as a tool for heterocycle CH functionalization method development. Now out in JOC
pubs.acs.org/doi/abs/10.1...

LinkedIn This link will take you to a page that’s not on LinkedIn

New #merckchemistry openings across our network #chemjobs
NJ Process (R334349): lnkd.in/eRytq_3D
NJ Discovery (R333164): lnkd.in/eXZptg8Z
Boston (R331298): lnkd.in/eBtz37w8
SSF (R333438): lnkd.in/e2xWkeCi
Philly (R331996): lnkd.in/ekiXyA88

Associate Scientist, Chemistry job in West Point, Pennsylvania, United States of America | jobs at Merck Apply for Associate Scientist, Chemistry job with Merck in West Point, Pennsylvania, United States of America. Browse and apply for the jobs at Merck

#chemjobs #Merckchemistry is hiring - 2 open positions at the associate level. Located at our West Point, PA site close to Philadelphia - with a great team that I just joined not so long ago! Links for info: R330195
bit.ly/40uICc9 R330192
bit.ly/42gC7v2 Please apply if interested #chemsky

Scalable Flow Electrosynthesis of Iminophosphoranes A scalable electrochemical process to synthesize iminophosphorane ligands is reported. The application of these iminophosphoranes was recently reported in Ni-catalyzed cross-electrophile and C–N cross-couplings. The use of parallel plate flow electrochemical reactors enables the synthesis of these iminophosphorane ligands on a multigram scale, with selected examples reported on up to 0.6 kg scale. Direct crystallization from the end of reaction mixture for selected ligands provides facile isolation processes. This article also details improvements in our electrochemical capabilities across scales, including addressing material compatibility issues, increasing accessible range of flow rates, and integration of process analytical technology tools.

Electrifying developments in kilo-scale electrosynthesis…a scalable flow electrosynthesis of iminophosphorane ligands is now published in #OPRD from #MerckChemistry Dan Lehnherr pubs.acs.org/doi/10.1021/...

High-Throughput Experimentation Reveals Scope and Limitations of Selective Phosphine Reductants and Enables One-Pot mAb Reduction/Conjugation This manuscript describes the detailed evaluation of more than 40 phosphine reductants via automated and nonautomated high-throughput experimentation approaches with the goal of identifying selective ...

High-throughput experimentation of mAb decapping guides phosphine reductant choice and improves one-pot decapping/conjugation conditions. @emmertlab.bsky.social #merckchemistry pubs.acs.org/doi/10.1021/...

High-Throughput Experimentation Reveals Scope and Limitations of Selective Phosphine Reductants and Enables One-Pot mAb Reduction/Conjugation This manuscript describes the detailed evaluation of more than 40 phosphine reductants via automated and nonautomated high-throughput experimentation approaches with the goal of identifying selective ...

First paper posting on #bluesky #chemsky 🍾
Ready for the holidays: ADC platform part 3! #merckchemistry pubs.acs.org/doi/10.1021/...
We use high-throughput experimentation to compare and contrast known and new phosphines as reductants for disulfide bonds. This leads to 1/3

A set of firefighting bunker gear sitting on a table

Staging for Monday’s TED-style talk about lessons learned on the fireground and navigating the difference between being a member of a team versus leading. #MerckChemistry

An image providing details of the award nomination process. The link in the post contains the same information

As my colleague David Thaisrivongs posted on LinkedIn: Attention chem grad students & postdocs: apply for the 2025 Merck Research Award for Underrepresented Chemists of Color! #MerckChemistry
Apply by Jan 17: survey.sogolytics.com/survey1.aspx...
Contact us at chemistsofcolor@merck.com #ChemSky

Nice work Steve #MerckChemistry and the Britton lab!

For the latest iteration of #MerckChemistry #CompChemSky history, I display possibly the last remaining scrap of paper evidence of the original name of the computational chemistry team: Molecular Systems or “MolSys”. Calculations were always on the fly… but on the level! #ChemSky

Jeopardy clue in the category she invented what? Crixivan is the answer to the clue of Kate and Chen helping to develop an HIV drug

The next installment in the history of #MerckChemistry #CompChemSky is the amazing work done by Kate Holloway on collaborative design of the HIV drug Crixivan. Not only did she use molecular modeling to contribute to the patent but she was then featured as a clue w/ Chen Zhao on Jeopardy!! #ChemSky

We are so grateful to have had the opportunity to interact with all the students and faculty above. Thank you again for your hospitality. Your science is an inspiration. #MerckChemistry

We couldn't resist swinging by Oxford & connecting with the MSD-Oxford CDT crew. You all impressed. Special thanks to @rhpdcu.bsky.social aka M. Willis for hosting. Oh & this guy... @drlcsquare.bsky.social did #MerckChemistry & team peptides proud. Catch more stories at #PharmtoTable PC.

With the resurrection of our SM family on #Chemsky, it seems the perfect time to thank a group of amazing folks in the Chemistry community with a first set of posts on this platform. It's been a busy 4Q for the #MerckChemistry Symposium series. First up, we had the chance to drop by Berkeley.