We're growing this effort. If you work in high-throughput experimentation, library generation, screening, or assay development, let's connect. DMs welcome!

At Cradle, we're building new capabilities for generating high-quality datasets at scale to improve model performance. Cradle's existing platform is remarkable and I'm excited to help expand what it can do.

Excited to announce I've joined www.cradle.bio as Head of Large Libraries.

The bottleneck in ML for protein engineering is data. Other domains train on massive existing datasets; in biology, every data point is generated experimentally and doing that well at scale is challenging.

Date: Thursday, October 30, 2025
Location: Bell Harbor Conference Center, Seattle WA
Link: nanoporetech.com/about/events...

Excited to share how long-read DNA @nanoporetech.com sequencing is accelerating Birch's AI-guided enzyme design! Check out the link and additional information in the reply.

#WYMMTour #nanopore

Excited to have Birch Biosciences be recognized as one of the top 25 Climate Tech Startups to Watch in 2025!

Check out www.birchbiosciences.com to learn more about how we are bringing plastics into the circular economy

AI in packaging: Leveraging new tech for recycling and real-time machine decision-making AI continues to transform the packaging industry landscape. While much of the focus had originally been on its use in automation and machine learning, nearly all packaging sectors have integrated some...

www.packaginginsights.com/news/ai-tran...

AI is revolutionizing an incredibly broad range of sectors. Enjoyed the chance to share how Birch Biosciences is using AI to power our enzymatic recycling technology.

Check out more details below!

Excited to share Birch Biosciences' progress towards a circular plastics economy at this year's SIMB conference!

If anyone in my network is heading to the 2025 Society for Industrial Microbiology and Biotechnology meeting in SF next week, let's connect!

Birch Biosciences Enters into Global Patent License Agreement with NREL to Advance Enzymatic Plastic Recycling Process Birch Biosciences, a startup focused on AI-powered enzymatic plastic recycling, today announced a global patent license agreement with the U.S. Department of...

Big news! Birch has entered into a global patent license agreement with NREL! This agreement will drive commercialization of our plastic recycling tech by combining NREL innovation and our AI-powered enzymatic platform. A big step toward circularizing plastics!

www.businesswire.com/news/home/20...

Company Spotlight: Birch Biosciences - WBGC Company Spotlight: Birch Biosciences, founded in 2022, is developing cutting-edge technology to address plastic recycling sustainability issues.

Super proud of the Birch Biosciences team and what we are building to circularize plastic manufacturing

webuildgreencities.com/company-spot...

Learn more about what we're up to at www.birchbiosciences.com

Re-Imagining the Plastics Industry: Sustainable Pathways to Achieve Circularity, Cost, and… We have spent a lot of time thinking about plastics and how this industry can be re-engineered to become more sustainable whilst driving…

A nice overview of the emerging circular technology in the plastics industry from Extantia Capital.

Excited to see Birch Biosciences' platform highlighted.

medium.com/extantia-cap...

Approach, datasets, and tasks

Miscalibration area vs. root mean square error (RMSE)

Active learning

Bayesian optimization

We compared the calibration of various machine learning uncertainty estimation methods for protein engineering.

No method excels across all scenarios, and uncertainty-based strategies for optimization often did not outperform methods without uncertainty.

Thanks @gerrich.bsky.social! Our recycling process is cost competitive with virgin plastics, creating circular high quality recycled material to allow for sustainable plastic consumption. We're excited about our tech and think there's space for up-cycling of waste into products as well!

www.darpa.mil/news-events/...

Birch is excited to announce an award to advance AI-enzyme design for plastic recycling w/ DARPA BTO. Only 9% of plastic is recycled, Birch is changing that. We're building the circular plastic economy using AI, enzymes and green chemistry www.birchbiosciences.com

In #NextGenSequencing news, we are starting to see accounts on real customers using the new Illumina $ILMN MiSeq i100 sequencer. One of the selling points of this instrument is that it is easy to use, and produces same-day results. The reports tell about being able to go from a library in a tube...

Three BioML starter packs now!

Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok

DM if you want to be included (or nominate people who should be!)

Started a second AI Science Connect pack. Let's keep building the community. It's been really amazing to see the great AI for science conversations over the past week.

Please self nominate, or send me others who should be added!

Pack 2: go.bsky.app/GnFTUM6
Pack 1 (full): go.bsky.app/JeFdryY

Rapid in silico directed evolution by a protein language model with EVOLVEpro Directed protein evolution is central to biomedical applications but faces challenges like experimental complexity, inefficient multi-property optimization, and local maxima traps. While in silico met...

A really nice application of pre-trained PLMs and supervised modeling for efficient directed evolution - a few different protein types too!

preprint version as well: www.biorxiv.org/content/10.1...

www.science.org/doi/10.1126/...

2nd! Would be great to get www.birchbiosciences.com on this list! A great resource by the way thanks @harrisbio.bsky.social !

Hi Ben, would love to be added. My company Birch Biosciences is using AI/ML to design enzymes for plastic recycling. Interested in efficient ways to leverage design-build-test-learn cycles for AI/ML guided enzyme engineering. Cheers!

🧪 For people interested in AI & enzymes (enzyme engineering, design, discovery, ...), I'm assembling a starter pack for us.

DM if you'd like to be included!

go.bsky.app/MhfaQBh

Birch Bio has an NSF funded postdoc for AI/ML and Comp Bio through i-perf.org#/. A great opportunity to gain startup experience. Help us revolutionize plastic recycling with generative AI, advanced enzyme engineering, and green chemistry! DM for details and please share broadly

Two BioML starter packs now:

Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc

DM if you want to be included (or nominate people who should be!)

InterPLM: Discovering Interpretable Features in Protein Language Models via Sparse Autoencoders Protein language models (PLMs) have demonstrated remarkable success in protein modeling and design, yet their internal mechanisms for predicting structure and function remain poorly understood. Here w...

This is pretty cool

www.biorxiv.org/content/10.1...

Birch Bio has an NSF funded postdoc for AI/ML and Comp Bio through i-perf.org#/. A great opportunity to gain startup experience. Help us revolutionize plastic recycling with generative AI, advanced enzyme engineering, and green chemistry! DM for details and please share broadly

Raphael Rodriguez and I wrote this historical perspective on Next Generation Sequencing by synthesis, because we were both postdocs in Shankar’s lab during the time it was being developed at Solexa…. 1/n🧵 www.nature.com/articles/s41...

go.bsky.app/2VWBcCd