Organellar insights in ageing and longevity - Nature Cell Biology This Review discusses the role of organelles, including the ER, mitochondria and lysosomes, as metabolic signalling hubs in ageing and longevity regulation, and highlights their crosstalk that maintai...

Organellar insights in ageing and longevity

www.nature.com/articles/s41...

Read the Research Article 'A conserved C. elegans zinc finger homeodomain protein, ZFH-2, is continuously required for the structural integrity and function of the alimentary tract and gonad' here.

journals.biologists.com/dev/article/...

Left: Antoine Sussfeld. Right: Berta Vidal (front left), Oliver Hobert (back) and Surojit Sural (front right).

To learn more about this work and the people behind it, we talked to Antoine Sussfeld, Berta Vidal, Surojit Sural @surojitsural.bsky.social and Oliver Hobert. journals.biologists.com/dev/article/...

Post-embryonic removal of ZFH-2 protein results in pumping defects. (F) DIC images of the pharyngeal-intestinal valve (vpi) in zfh-2(syb10278); osIs158[eft-3p::TIR1(F79G)] adults subjected to ubiquitous ZFH-2 depletion starting at mid-L1 stage. Animals were treated with either solvent (ethanol) or 100 µM 5-Ph-IAA starting at mid-L1. Scale bars: 10 µm.

From eating to mating: ZFH-2 is required for alimentary tract and gonad development in worms

This Research Highlight showcases work by Antoine Sussfeld, Oliver Hobert, @surojitsural.bsky.social & co. @columbiauniversity.bsky.social @hhmi-science.bsky.social

journals.biologists.com/dev/article/...

A panoramic view of the expression and function of the Doublesex/DMRT gene family in C. elegans A comprehensive analysis of all C. elegans DMRT proteins reveals sex-specific functions in nervous system development.

One of my core values as a scientist is community service, and a new paper gives me a chance to say that out loud. Our work on the DMRT genes is published! We looked at these genes important for sexual differentiation, mapping expression through development and functions at single-cell resolution.

Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging www.biorxiv.org/content/10.64898/2026.04...

C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron A conserved somatostatin pathway regulates sleep and physiology through a sleep-active neuron.

C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron

www.science.org/doi/10.1126/...

An integrated pipeline to count individual transcripts with single-cell resolution www.biorxiv.org/content/10.64898/2026.04...

The forkhead transcription factor FKH-7/FOXP acts in C. elegans chemosensory neurons to shape a life history strategy Abstract. Some organisms exhibit a remarkable ability to adapt their life history strategies within a single lifespan in response to dynamic biotic and abi

The forkhead transcription factor FKH-7/FOXP acts in C. elegans chemosensory neurons to shape a life history strategy

academic.oup.com/genetics/adv...

A panoramic view of the expression and function of the Doublesex/DMRT gene family in C. elegans A comprehensive analysis of all C. elegans DMRT proteins reveals sex-specific functions in nervous system development.

A panoramic view of the expression and function of the Doublesex/DMRT gene family in C. elegans

www.science.org/doi/10.1126/...

Parasites trigger epithelial cell crosstalk to drive gut–brain signalling - Nature Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occu...

New data from the Julius Lab show that crosstalk between epithelial tuft cells and enterochromaffin cells drives a gut-brain signal that turns parasite sensing into appetite suppression. Cool stuff!
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1

Whole-organism spatial transcriptomics at single-cell resolution in C. elegans www.biorxiv.org/content/10.64898/2026.04...

I would bet on the key chain model. When we deleted the first six Zn finger domains, it did not disrupt the function of the homeodomains. Why does ZFH-2 have so many Zn fingers then? We still don’t have a good answer.

Are you ready for *the* meeting about the evolutionary biology of Caenorhabditis and other nematodes? The abstract deadline is Wednesday!

EvoWorm 2026 will be held at McMaster University from June 16–19

Abstract deadline: April 15

Registration deadline: June 1

Details can be found at evoworm.org

Screenshot of live feed highlighting CBIOMES

Our tiny #Celegans astronauts are 30m out from docking with the #ISS! Tune in live here plus.nasa.gov/scheduled-vi...

#CBIOMES #spacebiology #microbiome #wormsinspace 🚀🧪🪱🦠

How do nervous systems produce behaviors? A new MIT study provides a detailed mechanistic mapping of exactly what happens in the brains of C. elegans worms when they “follow their nose” to savor attractive odors or avoid unappealing ones. picower.mit.edu/news/navigat... #neuroscience

Neural sequences underlying directed turning in Caenorhabditis elegans - Nature Neuroscience During olfactory navigation, Caenorhabditis elegans can execute error-correcting turns. Whole-brain imaging and perturbation experiments identify an ensemble of neurons that control reorientation and turning behaviors.

Open access study in @natneuro.nature.com by the lab of Steve Flavell: www.nature.com/articles/s41...

🚨 New lab preprint alert! 🚨
A study 6 years in the making, made possible by @simonsfoundation.org support : "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" now on #biorXiv: www.biorxiv.org/content/10.6... A 🧵 1/11 🧪🖥️🧬

Home | Spare Parts Spare Parts is a new Off-Broadway play starring Rob McClure and Matthew Walker that asks the question we’re all thinking but rarely say out loud: how far would you go to live forever?

Scientists in NYC, don’t miss this sci-fi Off-Broadway play ‘Spare Parts’! Tells the story of a billionaire who wants to fund a Columbia Professor in the quest to reverse his aging. Positively reviewed by the journal Science.
www.sparepartsplay.com

Thanks Javier!

All ZFHX family TFs have an unusually high no. of DNA binding domains, with some human homologs with 25+ domains. The 2nd and 3rd homeodomains of Ce-ZFH-2 are highly conserved with Hs-ZFHX2 homeodomains, and we found that these are essential for Ce-ZFH-2 protein’s function.

New preprint!
"A stereotyped glial attachment determines the morphology and function of neuronal cilia"
doi.org/10.64898/202...

We find that C. elegans neuronal cilia attach to glia, we identify a protein required for cilia-glia attachment, and we show that glial attachments alter cilia signaling.

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

"All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."
open.substack.com/pub/ofthebra...

A stereotyped glial attachment determines the morphology and function of neuronal cilia www.biorxiv.org/content/10.64898/2026.04...

The worm community has lost a true legend with the passing of Don Moerman. Don's impact on C. elegans research is beyond measure. A friend to many of us here in MN, his work has been invaluable, contributing >5,400 strains (VC & DM) to the CGC, 20% of our collection!

Global genomic diversity of the selfing nematode Caenorhabditis tropicalis correlates with geography www.biorxiv.org/content/10.64898/2026.04...

Environmental factors that impact the development of infective juveniles of entomopathogenic nematode Steinernema hermaphroditum www.biorxiv.org/content/10.64898/2026.04...

Huge thanks to all the co-authors, especially Berta and Antoine, who brought their expertise to map the functions of individual DNA binding domains of this protein using precise CRISPR editing. Here’s an interview of the people behind the paper:

journals.biologists.com/dev/article/...

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ZFH-2 is not only essential for animal development, but we found that it also has several roles during adulthood, when it is continuously required for the structural integrity and function of tubular structures in the alimentary tract and gonad.

journals.biologists.com/dev/article/...

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A conserved C. elegans zinc finger homeodomain protein, ZFH-2, is continuously required for the structural integrity and function of the alimentary tract and gonad Highlighted Article: Genetic loss-of-function analysis shows that the conserved C. elegans zinc finger homeodomain protein ZFH-2 is continuously required for structural integrity and function of alimentary tract but not for nervous system development.

Excited to share this study where we identified the functions of ZFH-2, a large (181 kDa) transcription factor of the evolutionarily conserved ZFHX family. ZFH-2 has 19 DNA binding domains: 16 zinc fingers and 3 homeodomains!

journals.biologists.com/dev/article/...

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