50 medical mycologists put their shoulder behind an action plan to mitigate the rising threat of antifungal drug resistance. Check out in Nature Medicine. @youngecmm.bsky.social @ecmmcandidaiv.bsky.social @ishamycology.bsky.social @bsmm-meeting.bsky.social @mrccmm.bsky.social

Harnessing random peptide mixtures to combat multidrug-resistant fungal infections | mBio The rising prevalence of invasive fungal infections, particularly among immunocompromised individuals, has become a critical public health concern. However, antifungal drug development has not kept pa...

journals.asm.org/doi/10.1128/...

Structural basis for TORC2 activation Zou et al., combining cryo-EM with structure predictions, report a high-resolution structure of TORC2 revealing previously unobserved flexible subunits and domains important for the regulation of kina...

www.cell.com/molecular-ce...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Our new paper in Nature Communications is out (Nature Portfolio):

How does a single mutation in a ribosomal protein drive blood cancer?

Turgor reduction triggers FERONIA nanodomain assembly for osmosensing in plants Osmotic stress reduces turgor pressure and relaxes the cell wall. Qin et al. reveal the critical role of the extracellular domain of FER in sensing turgor reduction, triggering FER clustering and acti...

www.cell.com/current-biol...

‘Without them there is no life’: the race to understand the mysterious world of Africa’s fungi Amid growing evidence of fungi’s key role in ecosystems and storing carbon, African scientists are championing the need to preserve ‘funga’ as much as flora and fauna

www.theguardian.com/environment/...

Dietary restriction shapes intergenerational ribosome abundance and early growth of Caenorhabditis elegans offspring Cells adjust their proteome to environmental conditions, but it remains unclear whether the proteome can be transmitted from parents to offspring. This study analyses the intergenerational effects of ...

journals.plos.org/plosbiology/...

Thrilled to have contributed to this chem–bio collaboration
@polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light

JACS: doi.org/10.1021/jacs...

How do proteins find their way to the cell's leading edge? @jimgalbraith27.bsky.social & @cathygalbraith.bsky.social break down how bleach line, FLOP, single-particle tracking, FCS & iPALM reveal intracellular fluid flow and an actin-myosin compartment barrier. doi.org/10.1038/s414...

Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities Strauss et al. utilize a high-throughput recombination platform to uncover the rules of yeast mating. They report that yeast display adaptive mate affinity and show that environmental context dictates...

Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities: Cell Reports
www.cell.com/cell-reports...

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator

www.biorxiv.org/content/10.1...

Lipid remodelling enables adaptation to chronic hyperosmotic stress
www.biorxiv.org/content/10.6...

In the trap of Arthrobotrys Nature Microbiology, Published online: 27 March 2026; doi:10.1038/s41564-026-02308-4Yen-Ping Hsueh used to think she was studying a fungus that traps nematodes. Fifteen years later, she realized she was the one who had been captivated, not by adhesive hyphae but by the irresistible mystery and quiet beauty of Arthrobotrys oligospora.

Out Now! In the trap of Arthrobotrys #MicroSky

A high-affinity split-HaloTag for live-cell protein labeling Nature Communications - Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse...

A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...

The Candida Genome Database’s new website is now live! Everything has been entirely rewritten from scratch! A quarter of a century old Perl code (some of which I wrote!) producing HTML 2.0 (😬) is all gone, with modern python in its place, producing modern webpages with JavaScript and CSS to make

NAC promotes co-translational protein folding at the ribosomal tunnel exit Santos et al. reveal NAC’s co-translational interactome, showing compartment-specific nascent chain interactions in human cells. NAC engages emerging chains at the ribosomal tunnel exit via a ribosome-oriented hydrophobic pocket, promoting early domain folding without stabilizing intermediate structures. These findings establish NAC as a co-translational chaperone integrating folding with protein biogenesis.

Online Now: NAC promotes co-translational protein folding at the ribosomal tunnel exit Online now:

A fungus that spreads from cats to humans has been detected, raising concerns among scientists A fungus called Sporothrix brasiliensis spreads from cats to humans, and concerns are growing over its rapid dispersal.

www.earth.com/news/fungus-...

A Novel Eukaryotic Ribosome Factor Enables Translation Restart Following Cellular Dormancy
www.biorxiv.org/content/10.6...

Image of News in focus article from Nature entitled "How bioRxiv changed the way biologists share ideas - in numbers"

The impact of bioRxiv in numbers

@richardsever.bsky.social

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

www.nature.com/articles/s41...

Mating fission yeast cells expressing Myo52-GFP (green), Cdc42-mCherrySW (Magenta) and mTagBFP2 expressed in P-cells (cyan). The cells fail to fuse, as shown by the cyan fusion marker confined to one of cell compartment. Image credit: Sajjita Saha.

Polarized growth in #Spombe needs Cdc42, but what role does it play in cell fusion? @sajjitasaha.bsky.social @sophiemartinlab.bsky.social &co show that mitotic polarized growth responds linearly to Cdc42 levels, but mating involves a sharp switch-like response @plosbiology.org 🧪 plos.io/4bvGIhb

Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast Endosomes serve as crucial sorting centers that streamline the distribution of cell surface proteins. The early endosome receives traffic from both th…

Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast

The work from Alejandro Melero @ameleroc.bsky.social and Miguel Basante-Bedoya just out in Current Biology.

www.sciencedirect.com/science/arti...

@biology-unige.bsky.social

Ribosome Molecular Aging Shapes Translation Dynamics
www.biorxiv.org/content/10.6...

We have a new paper out today from superstar Nora Herzog!

A virus that fluidizes the nucleus to enable replication!

Check it out here:

lnkd.in/e-xV8acK

This was an amazing collaboration with Ian Mohr and Angus Wilson

Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs Bacterial resistance to the vital last-resort antibiotic colistin is an increasing challenge. This study shows that magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher…

In new research, Yu-Ying Phoebe Hsieh, Ian O’Keefe, Ajai Dandekar, Harmit Malik &co reveal how magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher levels of resistance to colistin (a last-resort #antibiotic).
🧪#MicroSky

Comment une levure devient mycose

En élucidant le mécanisme qui rend le champignon microscopique Candida albicans capable de provoquer des mycoses, une équipe du CNRS ouvre la voie à de nouvelles pistes thérapeutiques.

You are finishing your PhD and looking to continue in science?

The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....

Thanks for reposting!

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

RNA-specific local translation is patterned by
condensates for multinucleate cell growth
www.nature.com/articles/s41...

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule The druggability of intrinsically disordered regions.

www.science.org/doi/10.1126/...