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Exciting new paper!!! Congratulations on the outstanding work! 🎉🎈🍾

Science is good. We should fund it.

Congrats, Ed and team! Very cool work!

Our newest paper is out online!

An Open-Source Code to Analyze Mitochondrial Intracellular Distribution from Fluorescence Microscopy Images

Congrats @giologia.bsky.social!

portlandpress.com/bioscirep/ar...

The Shocking Speed of China’s Scientific Rise When will Chinese research pull ahead of the U.S.’s?

"China’s population is four times the size of America’s, and its culture is unabashedly pro-science, even relative to other developed countries." 🧪

Why do intrinsically disordered proteins appear larger than they are in SDS-PAGE? We investigate how sequence properties affect SDS-PAGE mobility using synthetic IDRs.

Conclusion: We need to consider both SDS binding and the compaction of protein-SDS complexes.

www.biorxiv.org/content/10.6...

Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes We show that bi-allelic variants in the minor spliceosome snRNAs RNU6ATAC and RNU4ATAC cause early-onset autoimmune diabetes with immune dysregulation. We define a shared mechanism involving U12 intro...

🧬 New from Johnson et al!
📄Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes

Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...

Delays in awards and funding calls worry NIH-funded researchers Many programs may be pushed into the next fiscal year, and some could face funding gaps

The quiet part being illuminated: there have been very few new awards from NIH this fiscal year, for some very specific reasons 🆘

www.science.org/content/arti...

2026 STAT Madness 2026 bracket Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Explore groundbreaking innovations from

🚨Dear Bluesky friends, we need your help to advance in 2026 STAT Madness, the March Madness of Science tournament! 🏀🧪
Please vote for our Univ of Michigan Caswell Diabetes Institute team in your bracket before Mon March 9. Thank you! 🙏 www.statnews.com/feature/stat...

Private money cannot replace public funding of science Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public Health—particula...

A response to the opinion that private $ can replace the NIH.

Businesses are not charities. They work on profit margins. Decades of $ is essential for research to progress from an initial discovery to treatment. Most of the dirty work goes on in academic labs.

🧪 www.science.org/doi/10.1126/...

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

No records found matching your search criteria. Please alter your query and try again. search for new R01 from NHLBI in fy2026

NHLBI has not funded a single new R01 in FY2026 which began almost 5 months ago

Implanted flexible electronics reveal principles of human islet cell electrical maturation Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We im...

Delighted to share our latest now published in @science.org, where we developed "cyborg" pancreatic organoids to trace and stimulate functional human islet cell maturation.

We're excited for the potential as new tools for #diabetes research and therapy!

I am delighted to report that our latest paper has now been published in Science Advances:
www.science.org/doi/10.1126/...
In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.

Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling www.biorxiv.org/content/10.64898/2026.01...

Mito-nuclear communication: From cellular responses to organismal health Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic p...

www.cell.com/molecular-ce...

Exciting new work for the early detection of T1D onset from my colleague Lonnie Shea's lab here at Michigan! Happy to have played a small role. #GoBlue

Scientist who helped eradicate smallpox dies at age 89 A leader in the global fight against smallpox and a champion of vaccine science, William Foege died last Saturday

A leader in the global fight against smallpox and a champion of vaccine science, William Foege died last Saturday

Eppendorf? Their thermocyclers are awesome. Good call! Pricey but worth it IMHO. We have one that’s nearly 20 years old that still works wonderfully.

Just spoke to The Hill about how the dismantling of the NIH is impacting science in America. We still face a cliff of unfathomable heights, w easily 1000+ labs poised to close in the next year due to funding ending. A generation of young scientists lost because there is nowhere for them to train.

United States Senate Committee on APPROPRIATIONS = MENU Search 01.20.26 Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Daldad Aaaaains and

NIH budget bill out today.

It’s the result of heavy negotiations in Congress over past month+. 🧪

Big pic: NIH budget now is abt more than funding. It’s abt restraining the technical ways NIH is being broken by Proj 2025. And the restraints in the bill are tepid 🤷‍♂️

Also: watch ICE/DHS budget.
🧵1/

Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome #mitochondria
rdcu.be/eZXXC

Beta cell function and mass in individuals with and without remission of type 2 diabetes after Roux-en-Y gastric bypass - Diabetologia Aims/hypothesis In people with type 2 diabetes and obesity, Roux-en-Y gastric bypass (RYGB) can induce remission of diabetes. While RYGB has been reported to improve beta cell function in individuals ...

Individuals with remission of type 2 diabetes after RYGB have better beta cell function than those not achieving remission, but the groups did not differ with respect to beta cell mass. link.springer.com/article/10.1...

House Appropriations minibus bill funding NIH is out now.
- $400M increase
- Multiyear funding of new awards capped at 2025 levels.
- No line item for BRAIN Initiative

text here: docs.house.gov/billsthiswee...

Screenshots from Dem summary and Sec 240 (multiyear funding text).

Our review on GLP-1R signal compartmentalization is now out in JCI, where we discuss current evidence for the existence of GLP-1R–cAMP–PKA signalosomes at different subcellular locations and the complexity of the GLP-1R spatiotemporal signaling architecture:
www.jci.org/articles/vie...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Osteoprotegerin-Enabled Immune Evasion of Pathological Adipose Stromal Cells Drives Metabolic Dysfunction in Obesity Diet-induced obesity (DIO) promotes the accumulation of stromal cells with senescent characteristics in the adipose tissue (AT). Selectively clearing these cells—either through chemical senolytics or ...

New work on the mechanism by which certain deleterious (senescent-like) stromal cells evade immune clearance.

www.biorxiv.org/content/10.6...