Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes - Diabetologia Aims/hypothesis Although genome-wide association studies (GWAS) have identified loci associated with type 1 diabetes, the specific pathways and regulatory networks linking these loci to disease pathol...

Blencowe et al. used a computational pipeline to integrate #type1diabetes GWAS with tissue-specific functional information, such as the genetics of gene expression and gene regulatory networks, from a broad range of T1D relevant tissues or cell types. 🧪

link.springer.com/article/10.1...

Hoy en el XXXVII Congreso Nacional de la SED personal investigador #CIBERDEM ha participado en una mesa redonda sobre el camino hacia una mejor estratificación y predicción del riesgo cardiovascular asociado a la #diabetes🩸

Noticia completa🆕 www.ciberisciii.es/noticias/hac...

Analizan el papel del ácido palmítico y el ácido oleico, principales ácidos grasos de la dieta, en el desarrollo de la #diabetes mellitus tipo 2 🔎

Liderado por #CIBERDEM en la @ub.edu ➕participación #CIBERCV

🔗 www.ciberisciii.es/noticias/cal...

Bloqueo de los interferones: ¿podría ser una buena estrategia para la prevención de la diabetes tipo 1? - Revista Diabetes La diabetes tipo 1 (DT1) es una enfermedad autoinmune crónica caracterizada por la destrucción progresiva de las células β productoras de insulina debido al ataque del propio sistema inmunológico.

El bloqueo de los interferones podría ser una estrategia prometedora para prevenir la #diabetes tipo 1.
Esto es lo que discutimos en nuestro nuevo artículo en la Revista Diabetes de la Sociedad Española de Diabetes.

www.revistadiabetes.org/investigacio...

Schleh et al. identified alpha cell inflammation as a previously unrecognised hallmark of human pancreas ageing that is molecularly and functionally distinct from ageing beta cells. 🧪

www.biorxiv.org/content/10.1...

🚨 Final call to submit your abstracts for #EASD2026! Don’t miss the chance to present at the 62nd EASD #AnnualMeeting in Milan 🇮🇹.

📅 Deadline: Wed, 1 April 2026 | 🕛 18:00 CEST

Share your #research & join the global #diabetes conversation.

🔗 👉 Submit now via MyEASD: www.easd.org/annual-meeti...

β-Cell-Derived Extracellular Vesicles Boost β-Cell Functionality in Human Pancreatic Islets | Biomaterials Research Extracellular vesicles (EVs) are emerging therapeutic tools in nanomedicine, yet their effects in 2-dimensional (2D) versus 3D diabetes models remain underexplored. Unlike synthetic nanoparticles, EVs...

Boucenna et al. present a proof-of-concept study focused on exploring the potential of extracellular vesicles derived from human EndoC-βH1 cells to enhance β-cell functionality and insulin secretion. 🧪
#PancSky

spj.science.org/doi/10.34133...

⏰ 2 weeks left to submit your abstract for #EASD2026!

📅 Deadline: 1 April 2026 | 🕛 18:00 CEST

Don't wait! Submit your abstract now to present your work in Milan 👉 www.easd.org/annual-meeti...

#Diabetes #research #AbstractSubmission #AnnualMeeting

Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells Panzer et al. show that paracrine signals from beta and delta cells inhibit glucagon secretion from alpha cells by opening G protein-gated inwardly rectifying potassium channels. Loss of this inhibiti...

Panzer et al. show that the human alpha cell’s competence to secrete glucagon depends on paracrine inhibitory input from beta (serotonin [5-HT], γ-aminobutyric acid [GABA]) and delta (somatostatin [SST]) cells.

www.cell.com/cell-reports...

The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion - Diabetolo... Aims/hypothesis The two-pore domain K+ channel TWIK1-related alkalinisation-activated K+ channel 2 (TALK-2) is encoded by KCNK17, which is one of the most abundant beta cell K+ channel transcripts tha...

The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion #DiabetesResearch #BetaCells #Islets link.springer.com/article/10.1... 🔓

Elevated MANF expression in β cells protects mice from streptozotocin-induced diabetes by attenuating islet stress and immunogenicity Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing β cells, driven in part by endoplasmic reticulum (ER) stress an…

Li et al. demonstrate that elevated MANF levels protected against multiple low-dose streptozotocin-induced hyperglycemia, preserved β cell mass, enhanced proliferation, and reduced β cell DNA damage responses and islet lymphocyte infiltration. 🧪
#PancSky

www.sciencedirect.com/science/arti...

Implanted flexible electronics reveal principles of human islet cell electrical maturation Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We im...

Li et al. developed tiny, stretchable electronics that can be implanted into stem cell-derived pancreatic organoids, allowing for the in vitro monitoring of α and β cell maturation.

www.science.org/eprint/YSRND...

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles Effective therapies for type 1 diabetes (T1D) must both restrain immune hyperactivity and reduce β cell susceptibility to destruction. We describe a l…

Enriquez et al. describe a lipid nanoparticle platform for β cell-enriched mRNA delivery that can be further augmented by conjugation to enhanced glucagon-like peptide-1. 🧪
#PancSky

www.sciencedirect.com/science/arti...

Cambraia et al. suggest that calorie restriction improves glucose homeostasis and remodels the islet microenvironment to promote beta cell longevity through a pro-tolerogenic immune microenvironment, which reduces the risk of autoimmune diabetes. 🧪
#PancSky

www.biorxiv.org/content/10.6...

Contreras et al. suggest that receptor interacting protein kinase 1 (RIPK1) promotes β-cell demise in response to cytokine and autoimmune stress via actions on gene expression and kinase signaling. 🧪
#PancSky

www.nature.com/articles/s41...

🚨Save the Date🚨

After 22 years, the EASD Annual Meeting returns to Copenhagen, Denmark from 18 - 22 Sep 2028 🎉

We look forward to welcoming the global #diabetes community back to one of #Europe 's most inspiring cities.
Stay tuned for more details!#EASD2028

#diabetes #annualmeeting #savethedate

Safety and pharmacokinetics of teplizumab in children less than 8 years of age with stage 2 type 1 diabetes - Diabetologia Aims/hypothesis Teplizumab is approved in the USA and seven other countries to delay stage 3 type 1 diabetes onset in individuals ≥8 years of age with stage 2 type 1 diabetes. As part of a US Food and...

Up front & free to read in our Feb issue #editorspicks: Safety and pharmacokinetics of teplizumab in children less than 8 years of age with stage 2 type 1 diabetes doi.org/10.1007/s001...

Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes - Cell Death & Differentiation Cell Death & Differentiation - Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes

Yi et al. show that combining large-scale single-cell and bulk RNA-seq analyses can identify key features underlying alpha-cell resistance to diabetes-related damage. 🧪
#PancSky

www.nature.com/articles/s41...

Promotional graphic announcing that scientific submissions for EASD 2026 are open. Text highlights the dates “28 September-02 October” and the location “Milan, Italy.” A message invites researchers to submit abstracts to share their work with the global diabetes community. The design features red and white brush-stroke panels and a stylised skyline of Milan on the right, with “EASD 2026 Milan” and “easd.org” at the bottom.

🎯 Started preparing your #abstract submission for the 62nd EASD Annual Meeting? This is your sign to get started & share your #diabetes #research with the global community in Milan 🇮🇹 from 28 Sept - 02 Oct 2026.

🗓️ Deadline: 1 Apr 2026 | 🕛 18:00 CEST

Submit via MyEASD 👉 www.easd.org/annual-meeti...

Nuevo avance en la investigación contra el cáncer. Un equipo del @cniostopcancer.bsky.social, centro de dependiente del #ISCIII, logra resultados muy prometedores en modelo animal contra el cáncer de páncreas, abriendo nuevas vías para posibles ensayos clínicos.
⬇️
www.cnio.es/noticias/el-...

Promotional graphic reading “Call for Applications – EFSD/Novo Nordisk Foundation Future Leaders Award Programme.” Text explains the programme supports clinical and basic scientists in European diabetes research as they transition to tenured academic appointments and develop into future leaders. On the right, a photo shows a researcher using a microscope. EFSD logo and the website “europeandiabetesfoundation.org” appear at the bottom, set against a teal and green abstract background.

🚀 Apply now for the #EFSD/ @novo-nordisk.bsky.social Future Leaders Award! Supporting the next generation of #diabetes #research leaders in #Europe for up to 5 years.

📅 Deadline: 2 March 2026 | 🕛 12:00 CET

Apply now via the EFSD Programme Portal 👉 www.europeandiabetesfoundation.org/programmes/p...

Longitudinal monitoring of type 1 diabetes progression to disease onset Subcutaneous monitoring for type 1 diabetes identifies disease progressors from an at-risk group before symptom onset.

King et al. investigated the potential to delineate risk status (NOD versus NOR), eventual progression status (progressors and nonprogressors), and progression time frame via gene signatures derived from analysis of an immunological niche.
#type1diabetes

www.science.org/doi/10.1126/...

IL-21 mediates crosstalk between T cells and NK cells during the remission of type 1 diabetes - Nature Metabolism A pathogenic subset of NK cells is identified that promotes type 1 diabetes and is generated via T cell-derived IL-21.

Findings by Lei et al. reveal a mechanistic link, bridging adaptive and innate immunity, in the progression and remission of #type1diabetes that could potentially be exploited in T1D immunotherapy. 🧪

www.nature.com/articles/s42...

Jin et al. show that α-cell pyruvate kinase and the mitochondrial PEP cycle sense leucine and inhibit KATP channels similarly to β-cells, while restricting amino acid–stimulated membrane depolarisation and Ca2+ influx.

diabetesjournals.org/diabetes/art...

📣 The moment you've been waiting for is here: Abstract submissions for the 62nd EASD Annual Meeting are officially open! Share your work with the global #diabetes community in Milan from 28 Sept - 02 Oct 2026.

📅 Deadline: 01 April 2026|🕛 18:00 CEST

👉 Submit via MyEASD: www.easd.org/annual-meeti...

One week to go!

Our virtual workshop “What’s going on in diabetes research?” takes place on Jan 23, 2026. 🔬🧪

The final program is out and colleagues worldwide are joining. 🌍

Free registration: t.co/dvRyM3HMV9

AMP deaminase-2- and adenosine deaminase-mediated disposal of β-cell intracellular adenosine protects against multiple low-dose streptozotocin-induced type 1 diabetes To evaluate the importance of AMPD2 and ADA, two adenosine disposal enzymes, for β-cell survival and the development of T1D.The nucleotide metabolism …

Singh et al. show that β-cells differ from α-cells in terms of the metabolism and disposal of intracellular adenosine, which makes β-cells more vulnerable to ATP-depleting stress, and therefore also more prone to being attacked by the immune system in T1D. 🧪

www.sciencedirect.com/science/arti...

Galectin-3 exacerbates autoimmune diabetes by limiting regulatory T cell differentiation and function Galectin-3 activates LAG3 to inhibit Treg cell differentiation and function, thereby triggering immune imbalance and insulitis.

Xie et al. report that serum Galectin-3 levels are significantly elevated in patients with #type1diabetes and that serum Galectin-3 are positively correlated with circulating LPS concentrations resulting from increased intestinal permeability. 🧪

www.science.org/doi/10.1126/...

Beta-cell-specific C3 deficiency exacerbates metabolic dysregulation and insulin resistance in obesity C3 is highly expressed in human and rodent pancreatic islets, which secrete insulin to regulate blood glucose homeostasis. We have previously shown th…

King et al. generated a beta-cell-specific complement C3 knockout mouse to test whether cell-intrinsic C3 is required for beta-cell function in a whole animal model. 🧪
#PancSky

www.sciencedirect.com/science/arti...