TALK-2, a K+ channel associated with diabetes, controls human beta cell ER Ca2+ handling, promoting basal insulin release and limiting glucose-stimulated insulin secretion #BetaCells #Islets #DiabetesResearch

The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion - Diabetolo... Aims/hypothesis The two-pore domain K+ channel TWIK1-related alkalinisation-activated K+ channel 2 (TALK-2) is encoded by KCNK17, which is one of the most abundant beta cell K+ channel transcripts tha...

The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion #DiabetesResearch #BetaCells #Islets link.springer.com/article/10.1... 🔓

Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
A comprehensive overview of insulin resistance, β-cell dysfunction, prevention strategies, and therapeutic approaches in T2D
doi.org/10.1038/s413...
#Type2Diabetes #InsulinResistance #BetaCells #DiabetesTherapy

🧬What if #betacells aren’t all the same?
Professor Andrew Pospisilik shares new epigenetic evidence that could reshape our understanding of #diabetes and #heterogeneity - from beta cell subtypes to #obesity endotypes.
📺Watch now:🔗 easd-elearning.eu/episode/359/...

New findings on the link between ER stress and beta cell proliferation #BetaCells #Islets #DiabetesResearch

Transient ER stress cell-autonomously promotes beta cell cycling in mice - Diabetologia Aims/hypothesis Regenerating endogenous pancreatic beta cells is a potentially curative yet currently elusive strategy for diabetes therapy. Mimicking the microenvironment of the developing pancreas a...

A novel link between ER stress dynamics and beta cell proliferation: transient ER stress promotes beta cell proliferation in a cell-autonomous manner. #Diabetes #DiabetesResearch #CellStress #BetaCells link.springer.com/article/10.1... 🔓

Frontiers | Editorial: Advances in β-cell development & regeneration This is a provisional file, not the final article pathogenesis of diabetes mellitus is fundamentally linked to a decline in pancreatic β-31 cell mass (1). Re...

🎉 Our editorial "Advances in β-cell Development & Regeneration" is now published in @frontiersin.bsky.social! We explore restoring functional β-cell mass for diabetes therapy. Thank you to all authors.

Read & share: doi.org/10.3389/fend...

#diabetes #regenerativemedicine #betacells

Acute and resolving inflammation differentially regulates beta cell function in mice via interactions between peritoneal and islet-associated macrophages - Diabetologia Aims/hypothesis Islet-associated macrophages regulate beta cell function during inflammation and tissue repair, but evidence for their role during metabolic adaptation and its failure is more limited....

Macrophages within islets and the peritoneum interact to regulate beta cell function during peritonitis and type 2 diabetes #T2D #DiabetesResearch #BetaCells #Islets link.springer.com/article/10.1...

Study shows that neonatal #betacells sense gut microbiota-derived #bileacids via #FXR, limiting their development. Declining postnatal beta cell FXR expression allows normal neonatal beta cell growth and reduces #diabetes risk link.springer.com/article/10.1...

MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1 - Diabetologia Aims/hypothesis A highly specific mosaic transcriptional environment guides the fate of pancreatic progenitors during development and maintains the identity of mature endocrine cells. In mice, one suc...

New research reveals MNX1 prevents SST expression and maintains beta cell identity by repressing PERCC1. This insight may help understand beta cell function and plasticity. #DiabetesResearch #BetaCells
link.springer.com/article/10.1... 🔓

The peptide hormone spexin restores beta cell function by targetting the islet beta cell sodium–potassium pump in a mouse model of #diabetes #DiabetesResearch #Islets #BetaCells

Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium–potassium pump - Diabetologia Aims/hypothesis Clinical studies revealed that serum spexin level is positively associated with beta cell function. However, the role of spexin in beta cells remains unclear. We hypothesise that spexi...

Spexin targets islet beta cell sodium–potassium pump to increase insulin secretion and beta cell mass, leading to a decrease in glucose levels in diabetes mouse model. #DiabetesResearch #Islets #BetaCells link.springer.com/article/10.1... 🔓

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...

Loss of LONP1 leads to mitochondrial protein misfolding in β cells and contributes to type 2 diabetes (T2D).

🔗 www.nature.com/articles/s42...

🔬 led by @soleimanpourlab.bsky.social (U Mich)

#T2D #Mitochondria #Proteostasis #BetaCells (5/8)

We built ‘maps’ 👩‍💻 showing that pancreas progenitors with nearby supporting cells form #niches &
used #stemcells to recreate these niches in the lab 🧪🧫
& study how human #betacells develop

🙏Many thanks to the Editor & Reviewers for 👍 insights
🙏 Funding @wellcometrust.bsky.social @ec.europa.eu

This is how happy we get when we create beta cells in the lab! 🎉
@rksullivan.bsky.social joy says it all after successfully growing some beautiful beta cells - smiles all around 😊
More exciting research updates coming soon!
#KCLT1DiabetesGrandChallenge #BetaCells #StemCellResearch

Adaptive mechanisms in pancreatic islets involve remodelling of defective cardiolipin, counteracting mitochondrial dysfunction in #BarthSyndrome #Islets #BetaCells #DiabetesResearch

I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression - Diabetologia Aims/hypothesis The bromodomain and extra-terminal (BET) protein family acts as ‘epigenetic readers’ to identify the acetylation marks on histones that convert the acetylated lysine residues into observable phenotypes. BET proteins have gained attention due to their ability to modulate the transcription of pathology-related genes involved in cancer and autoimmune diseases, including type 1 diabetes mellitus. However, targeting BET proteins may have secondary effects on other host cells. We aimed to elucidate possible secondary effects of BET inhibition on pancreatic beta cell function. Methods We studied the effect of the small-molecule BET inhibitor I-BET151 on pancreatic beta cells in vitro, ex vivo and in vivo. GTTs, ITTs and glucose-stimulated insulin secretion assays were performed in healthy mice and a mouse model of diabetes following daily i.p. injections of I-BET151 for 2 weeks. Transcriptomic analysis was carried out on primary mouse islets, which were subjected to ex vivo I-BET151 treatment. Changes in expression were further validated in primary human islets. Results Administration of I-BET151 modestly but significantly increased glucose excursions and reduced insulin responses in both healthy mice and diabetic mice. We found that I-BET151 exposure significantly reduced the expression of Hnf4α (also known as Hnf4a; MODY1), Gck (MODY2), Hnf1α (also known as Hnf1a; MODY3), Glut2 and other genes essential for beta cell function in rat INS-1E insulinoma cells and in mouse primary islets and human islets. Global gene expression analysis in cells treated with I-BET151 showed a downregulation of the phosphoinositide-3-kinase (PI3K)–Akt pathway. Downregulation of forkhead box protein O1, a downstream transcriptional factor of the PI3K–Akt pathway, partially rescued I-BET151-driven downregulation of Gck and insulin secretion. Likewise, islets from I-BET151-treated mice showed a modest reduction in glucose-stimulated insulin secretion. Conclusions/interpretation The results presented here suggest that BET inhibition therapy should be used with caution due to possible bimodal effects at high concentrations at the detriment of pancreatic beta cell function. Graphical Abstract

New data show that the BET inhibitor I-BET151 modulates glucokinase gene expression and beta cell function, suggesting that BET inhibition therapy should be used with caution due to possible bimodal effects #BetaCells #DiabetesResearch link.springer.com/article/10.1... 🔓

New study on the role of intermittent fasting on restoration of pancreatic beta cell identity and autophagy in KATP-induced diabetes #DiabetesResearch #BetaCells #Islets #MedSky

Presenilin-1 controls glucose metabolism and identity of pancreatic beta cells Presenilin 1 is an endoplasmic reticulum protein, most known for its role in the pathogenesis of familial Alzheimer's Disease (AD). Presenilin 1 has been attributed roles in intracellular calcium home...

🚀 Thrilled to share our new preprint is live!
“Presenilin-1 controls glucose metabolism and identity of pancreatic β-cells”
We uncover how Presenilin-1 shapes β-cell metabolism and fate.
Check it out 👇
🔗 doi.org/10.1101/2025...

#Diabetes #BetaCells #Metabolism #Preprint #bioRxiv

Original post on mastodon.social

🧬 Breaking: Stem cell therapy for Type 1 diabetes showing 65-80% improvement rates in trials! Patients going from multiple daily insulin shots to little/no external insulin needed.
The future of diabetes treatment is here - learn about the groundbreaking research → […]

Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ

Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ

Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ

Meet Prof. Shanta Persaud – PI on the T1D project + expert in beta cell biology at King’s! She’s a passionate educator, runner, boxer, skier, music lover (Beyoncé recently), Tate Modern member + quiz night fan. A true research powerhouse.

#T1D #STEM #KCL #BetaCells #WomenInSTEM

Don´t miss Andreas talk today‼️ He will be speaking about his volume EM work in pancreatic beta cells.
#DiabetesResearch #volumeEM #BetaCells
👇👇👇

‪Study looking at human islet proteome changes in stage 1 #T1D, showing increased inflammation and decreased endoplasmic reticulum stress. #Islets #BetaCells #DiabetesResearch #Proteomics #Endocrinology #MedSky

🔬 the(sugar)science Th1nk Tank presents: How Does Immunometabolism Influence T1D Remission? with Clive Wasserfall, PhD & Jason Collier, PhD

🔗us02web.zoom.us/meeting/register/cl8iSfg...

#T1D #Immunometabolism #BetaCells #Autoimmunity #Th1nkT1D #TheSugarScience

🧬 the(sugar)science Th1nk Tank presents: From Sex to Systems: Molecular Signaling in Beta Cells with Fahd Qadir, DVM MS PhD (Tulane)

🔗us02web.zoom.us/meeting/register/v09Y2eu...

#BetaCells #T1D #SystemsBiology #Endocrinology #DiabetesResearch #Th1nkT1D #TheSugarScience

Graphic promoting an EASD podcast episode titled “Generation of pancreatic islets from stem cells.” The image shows two speakers (Prof. Raphael Scharfmann and Prof. Valeria Sordi) seated on a sofa holding blue microphones, with the EASD logo and an audio waveform graphic on a blue background.

🎙️ can stem cell-derived beta cells cure diabetes?

In this episode, Dr. Raphael Scharfmann (@inserm.fr ) & Dr. Valeria Sordi (IRCCS San Raffaelle) unpack how close we are, the immune hurdles, & why scale matters.

🎧Listen now 👉 www.easd.org/media-centre...

#diabetes #BetaCells #T1D #podcast

New data on the role of lipotoxic hepatocyte-derived extracellular vesicles in islet inflammation and β cell dysfunction #Islets #BetaCells #DiabetesResearch #Endocrinology #MedSky