Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ

Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ

Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ

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Paper
Details
#LiquidLiquidPhaseSeparation #ProteasomalDegradation #OuyangWangResearch

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academic.oup.com/nar/article/...

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www.nature.com/articles/s41...

My continued biological education
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