Visualization of PKA regulatory subunit RIα (green) forming phase-separated condensates with the catalytic subunit (red) in MIN6 β cells, revealing dynamic protein organization within the cytoplasm. Cell nuclei are marked in blue. Image Credit: Julia C. Hardy
The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @plosbiology.org 🧪 plos.io/4o9onKQ
0
0
0
0