Previously unrecognized immune response could enhance defense against cancer In a paradigm breaking study, Dr. Pavan Reddy, director of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine (BCM) and his team,...

Drs. P Reddy, A. Chinnaiyan, M Cieslik et al discovered a novel way the body can attack #cancer. #CD4Tcells @bcmhouston.bsky.social @umich.edu #NatImmunol www.bcm.edu/news/previou...

Stroke Atlas
anratherlab.shinyapps.io/strokevis/

Single-cell transcriptomics 🐭Brain+Blood
2 & 14 days post-stroke
♀️♂️
Young(2~3 mo) Aged (17~20 mo)

9 #EndothelialCell clusters
IGF1 signals

#Aging
⏫interferon signals in post-stroke🧠EC (+immune cell)

#NatImmunol 2024
www.nature.com/articles/s41...

Deactylation by SIRT1 enables #LiquidLiquidPhaseSeparation of IRF3/IRF7 in innate antiviral immunity

"Site-specific acetylation of IRF3/7 DNA-binding domain abrogates LLPS"
"Reinforcing SIRT1 activity rescues innate #Immunosenescence" (HSV-1 SeV VSV)

#NatImmunol 2023
www.nature.com/articles/s41...

Fibroblast diversity in #Arthritis ▶️ ⏫CD200+FGFR2+CDH11hiCol12A1hi fibroblast during inflammation resolution

#Visium #SpatialTranscriptomics analyzed with #BayesSpace➡️
Co-occurrence
Pre-resolving CD200+ fibroblasts with ILC2, eosinophils

#NatImmunol 2024
www.nature.com/articles/s41...