Our paper is (finally) out in Cell today!

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...

Great collaborative effort - read more from first author @asamelson.bsky.social below:

Congratulations on passing your qualifying exam, Reet Mishra! 🍾

#kampmannlabproud

Kampmann lab Halloween costume this year:
Revenge of the lab rats
(Including several KO mice)

Happy 👻🎃

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.

Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.

Alzforum
www.alzforum.org/news/researc...

Preprint
www.biorxiv.org/content/10.1...

Apply by Oct 15 - please spread the word!

Find the CrAAVe-seq plasmid pAP215 here: www.addgene.org/217635/
Exciting work, thanks for sharing!

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes

@kampmann.bsky.social @ivlrose.bsky.social

www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

Thank you, John!

Very honored to receive this year's Byers Award in Basic Science!
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.

www.ucsf.edu/news/2025/07...

Farewell party for 4 great lab members, excited for their next adventures: Biswa Ramani (starting the Ramani Lab ‪@ucsanfrancisco.bsky.social‬), @venushagan.bsky.social (PhD @ucsanfrancisco.bsky.social‬), Cristian Chavira (PhD ‪@uwmadison.bsky.social‬), Kean Ehsani (Ramani lab). Thanks & best wishes

Bethesda Declaration — STAND UP FOR SCIENCE Support NIH Staff Now!

Stand up for science - stand up for the NIH!

I just signed the support letter for the #BethesdaDeclaration.

Please consider signing as well:

www.standupforscience.net/bethesda-dec...

Farewell to Emily Marzette. Thank you so much for your many contributions to the lab! We will miss you lots but are excited for you to start grad school at UCLA!
🎉

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

www.alz.org/news/2025/ke...

Congratulations Rudra Bose, on passing your qualifying exam with flying colors!
🎉🎉🎉
#kampmannlabproud

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢

Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪

Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up.

I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵

Congratulations Dr. @parkergrosjean.bsky.social! 🎓🎉🎉🎉

Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity.

We are missing you already - but excited for your next adventures at @insitro.bsky.social!

congratulations, @fredchanglab.bsky.social 🎉

It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:

Thank you, Anne! :-)

thank you Emily :)

Thank you Frank :)

Excited for our iAssembloid work, led by @emmyli.bsky.social to be featured on the cover of today's issue of @cp-neuron.bsky.social

How to Build Bold Thinking to Foster Scientific Breakthroughs Martin Kampmann, PhD, and Anna Victoria Molofsky, MD, PhD, are the 2025 recipients of the Bowes Biomedical Investigator award, which supports scientists who take novel approaches and have the potentia...

Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social
😊🎉🎉🎉

www.ucsf.edu/news/2025/02...

In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...

Congratulations Dr. Olivia Teter! 🎓🎉🎉🎉

Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots.

All the best for your next adventure at Calico!

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence