Some reports say over 500 schools, 55 libraries, & 25 universities hit.
You can debate the numbers, but hitting Sharif University & Beheshti is like hitting MIT & Stanford. I keep wondering: How would the scientific community respond differently if it was those universities? Whatโs the difference?
The planet Jupiter with its cloud bands seen in shades of pink, rusty red, blue, and purple. The Great Red Spot is a deep navy blue, surrounded by bands and swirls of pink, and light blue.
Hubble's ultraviolet view of Jupiter shows the planet in hues of pink and blue.
jupiter wishes you a very happy trans day of visibility ๐ณ๏ธโโง๏ธ
Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.
๐ฅ๐The Psychosis Collective proudly presents our first preprint
๐๐ฅ๐จ๐ณ๐๐ฉ๐ข๐ง๐ ๐ฌ๐ฎ๐ฉ๐ฉ๐ซ๐๐ฌ๐ฌ๐๐ฌ ๐๐ฎ๐ญ๐จ๐ข๐ฆ๐ฆ๐ฎ๐ง๐ข๐ญ๐ฒ ๐๐ซ๐ข๐ฏ๐ข๐ง๐ ๐ฉ๐ฌ๐ฒ๐๐ก๐จ๐ฌ๐ข๐ฌ-๐ฅ๐ข๐ค๐ ๐๐๐ก๐๐ฏ๐ข๐จ๐ฎ๐ซ ๐ข๐ง ๐ฆ๐ข๐๐
๐ ๐ฅ๐ช๐ด๐ค๐ฐ๐ท๐ฆ๐ณ๐บ ๐ซ๐ฐ๐ถ๐ณ๐ฏ๐ฆ๐บ ๐ช๐ฏ ๐ต๐ฉ๐ณ๐ฆ๐ฆ ๐ข๐ค๐ต๐ด
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread๐งต
๐ Neuromatch is looking for more TAs to help facilitate comp neuro + neuroAI learning this summer! You'll get to work with students from around the world and share your expertise with the global community ๐ง ๐ ๐ค ๐๐ป ๐ #cosyne2026 #neuroscience
#Cosyne2026 check out poster 3-104 by @atika-syeda.bsky.social to learn about the impact of behaviors on visual cortical activity ๐ง ๐ญ
For this year's Neuromatch Computation Neuroscience course, the Curriculum Team is adding a new Day ๐ฅ๐ฅ๐ฅ
Time series analysis and signal processing!
We're looking for 5-10 content contributors with relevant neuro+DSP experience for various tasks: co-Day Lead, video, slides, code tutorials, etc.
Friday, 13:15 (Poster 2-048) at @cosynemeeting.bsky.social #cosyne2026: @allierced.bsky.social and @lappalainenjk.bsky.social present how they made GNNs learn interpretable circuit models from neural activity. Code: saalfeldlab.github.io/flyvis-gnn/
This week we are introducing neuromodulatory assembloids.
Over the past few years, many circuits and cell-cell interactions have been modeled in assembloids, but these systems have not systematically incorporated neuromodulation.
1/7 ๐ง My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! ๐งต
I have just arrived at @cosynemeeting.bsky.social ! During my flight, as I thought about opening remarks (and had a glass of wine), I got to reflect on why I love neuroscience. Maybe other folks are doing the same and would like to read or add, so I thought I'd do something unusual and share!
Whether the hippocampus is involved in unrewarded learning has been a controversial question. A new preprint finds that it may be critical for passively learning information.
By @natmesanash.bsky.social
#neuroskyence
www.thetransmitter.org/memory/hippo...
There's no better way to learn than to teach! Help make NMA a resounding success!
New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans: www.biorxiv.org/content/10.6....
As our lab's first foray into comparative analysis of neural dynamics, Iโm super excited about this work! 1/18
Will you be at COSYNE 2026? Come see us at the Neuromatch booth
We're excited for #COSYNE2026 in Lisbon, Portugal, 12โ17 March!
Weโre looking forward to connecting with the community and sharing our work at @cosynemeeting.bsky.social. If youโre attending, letโs meet and continue building an open, collaborative #CompNeuro ecosystem.
www.cosyne.org
First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...
It was bad when I thought a human had okayed it and itโs bad now that it looks like an AI did, bc this is EXACTLY why they wanted that thing - so that when people call them monsters for bombing a school full of little girls, they can say โcomputer glitch, wasnโt our fault, you canโt call us thatโ
Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday
Are you working at the interface of #neuroscience and ML/AI? Share your research at Janelia in Nov! ๐ง ๐ค janelia.news/NAI26
Years ago I registered glue [dot] wiki because of the sheer quantity of contextual knowledge surrounding glue in research that literally has no venue or medium of knowledge transfer
Thrilled that my paper is out in the @nature.com. We explored how the brain builds complex tasks by compositionally combining simpler sub-task representations. The brain flexibly performs multiple tasks by dynamically reusing neural subspaces for sensory inputs and motor actions
rdcu.be/eRVUk
5) Code is available at github.com/mouseland/su.... Thanks also to contributions from Chris Ki, Nicholas Del Grosso, @lafosse.bsky.social , and @qqzhang.bsky.social ! ๐ฅ๐ป pip install suite2p --upgrade ๐ป๐ฅ
Suite2p GUI features including correlation visualization, automated ROI merging, motion-correction movie viewing, registration metrics, and Rastermap visualization of neural activity
4) Suite2p has a GUI with many visualizations and tools - we recommend starting there to run the algorithm and explore the data.
ROI detection. a, Frames are binned in time (left) and then high-pass filtered in space and time (right). b, Time-averaged thresholded activity from convolved square templates of different sizes. c, Initialization of new ROI with best fitting square template from b. d, Initial time trace corresponding to the dot product of the template in c with each movie frame. e, Iterative template refinement for four example ROIs. f, Example region with many cells detected and their spatial overlaps (top left), temporal overlaps (top right) and active frames crossing the threshold (bottom). g, Detected ROIs divided by the sizes of their initial square templates.
3) We developed an ROI detection algorithm which implements matrix decomposition with L0-sparsity constraints in both space and time.
a, Reference image is computed by iterative re-alignment of a random subset of frames. b, Rigid motion offsets are computed by correlation of whitened reference and frame, i.e. phase correlation. c, Calculated X/Y rigid motion offsets. d, Non-rigid motion offsets computed by dividing image into overlapping blocks, computing phase correlation in each block, smoothing across blocks, taking the optimal shifts per block and upsampling them via bilinear interpolation. e, Timing as a function of number of frames in recording - Hz estimated from slope
2) Motion correction is very important in recordings of awake, behaving animals. We perform *fast* non-rigid motion correction (170 frames per sec).
Suite2p pipeline. a, Example volume imaging data. b, X/Y motion correction (left: before, right: after). c, ROI detection (left) and trace extraction with neuropil extraction based on surrounding pixels (right). d, Classification of ROIs into somatic and non-somatic (i.e. dendrites and other neuropil). e, The graphical user interface (GUI) can be used for manual curation and results visualization. f, Multi-plane recording of over 100,000 neurons using a standard Thorlabs Bergamo2 scope (see Methods for exact configuration). Somatic ROIs for example plane shown in different colors. g, Neural activity raster from recording in f, with neurons sorted by Rastermap, colored by the corridor that the mouse is in
1) Suite2p is a complete pipeline for processing large optical recordings of neurons, including motion correction, ROI detection, classification, and manual curation.
๐ฌ๐ง Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but donโt have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...
President Mandela said, "there can be no keener revelation of a society's soul than the way in which it treats its children."
$1.65M per day in DC alone. Thatโs approximately two NIH R01 Grant *years* burned per day. Ninety *five year* R01s projects burned in the last seven months with no end in sight.
Instead of lasting scientific advance we getโฆ.what?
Civil rights violations and authoritarian replacement of democracy.
๐จ new work from the lab on how eye movements ๐ versus orofacial movements influence ๐ญ visual cortex activity ๐ง #neuroscience #behavior #neuroAI
Excited to share โOrofacial behaviors, not eye movements, govern neural activity in mouse visual cortexโ
www.biorxiv.org/content/10.6...
Summary below...
