Measuring immune function in the wild is key to understanding resilience and disease. New open‑access research presents a practical immune toolkit for wild ungulates, revealing variation across individuals, populations and landscapes in bighorn sheep.
vist.ly/4z6gk
Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments.
vist.ly/4wxid
Call for reviewers. Become an ad hoc reviewer for the BSI journals. British Society for Immunology. Oxford University Press.
Discover benefits available when you become a peer reviewer for the @britsocimm.bsky.social journals, including a chance work with immunology experts to advance research.
🔗 oxford.ly/4sz3vPa
#ImmunoSky @ceijournal.bsky.social @imtadvances.bsky.social @discovimmunol.bsky.social
New study by Priscilla Y. L. Tng et al. shows how virulent ASFV strains disrupt the innate–adaptive immune axis in vivo, key insight for developing safer, more effective ASF vaccines.
Read the article here: vist.ly/4w8sr
#CelebrateVaccines #Immunology #VaccinesWork
📣 Last chance to submit!
The Advances in Veterinary Immunology Special Collection, led by Prof. Jayne Hope, is open for submissions until the end March 2026.
Share your work on veterinary immune systems, comparative immunology, vaccines, and One Health research.
Submit: vist.ly/4uscp
New open‑access study by Maria Z. Krauss et al. shows how amino acid uptake and mTOR signalling in CD4⁺ T cells power immunity to Trichuris muris. SLC7A5 proves essential, and loss of mTOR leads to chronic infection.
🔗 https://vist.ly/4unhy
Studying how environment shapes immunity? 🌿🧬 The Ecoimmunology Special Collection is open for submissions, spanning wild systems, naturalised lab models, holistic human studies, and computational advances.
Learn more: academic.oup.com/discovimmunology/pages/c...
🐏 New study on wild bighorn sheep reveals major axes of immune variation across 581 individuals, driven by innate–adaptive trade-offs, inflammatory states, age, and sex.
A field‑ready toolkit for understanding wildlife immunity at scale.
🔗 vist.ly/4u8r6
#WildlifeHealth #EcoImmunology
CASPASE‑8 supports T cell survival through mechanisms beyond repressing RIPK1‑dependent necroptosis. Conditional deletion studies reveal its essential role in CD8⁺ T cell maintenance and NKT cell development.
Read more: https://bit.ly/4r8Edqc
🧬 New research shows lung basal cell–derived PROS1 reduces COVID‑19‑induced inflammation and enhances antigen presentation in monocytes.
Read the study: https://bit.ly/3MBrSMh
#COVID19Research #Immunology
📣 We’re delighted to see our latest African swine fever research featured on the @pirbrightinst.bsky.social blog
The study uncovers how ASFV rapidly disrupts the immune system in pigs, shedding new light on why the virus is so hard to control.
Read the blog 👉 https://bit.ly/4kn8bnK
📢 Call for papers!
Discovery Immunology invites submissions for our Special Collection on Advances in Veterinary Immunology, led by Prof Jayne Hope.
We welcome research and reviews across comparative, translational and One Health immunology.
Submit by March 2026: https://bit.ly/3WmPhl3
🔬 In Discovery Immunology, Katie J Smith, Giuseppe Sciumè & Shoba Amarnath review the complex world of ILC1s—their roles in anti-tumor immunity, their plasticity, and how PD‑1 shapes their function.
Read the open access article: https://bit.ly/4fnU0N0
#Immunology #ILC1 #CancerImmunology
🔬 Discovery Immunology features a review by Sara Alonso & Karen L. Edelblum exploring how intestinal microenvironments and the gut microbiota shape the metabolism and function of γδ intraepithelial lymphocytes.
Read the open access article: https://bit.ly/4a6rY6a
🔍 See the research that made the biggest impact this year!
Check out our 2025 must‑read articles, featuring the most-read and most‑cited work
Read more: https://bit.ly/45ELeXc
#Immunology
Type‑17 immunity shows up in the gut: axSpA stool contains increased IL‑17A, IL‑23 & GM‑CSF, alongside systemic Th17 activation.
Metabolomics points to microbial metabolic links.
Read here: https://bit.ly/4nkhC7q
How do human ILCs adapt to lung niches?
Single‑cell profiling shows distinct vascular vs. tissue programs and a shared extravascular “tissue signature” with NK cells.
Read here: https://bit.ly/4qiLJP6
Submissions now open for the Extracellular Vesicles & Immune Function topic—exosomes, microvesicles, immunomodulation, disease mechanisms & therapy.
Submit by May 2026: https://bit.ly/3YpmLRI
High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions.
A look into avian antibody evolution: https://bit.ly/45wSe95
Happy holidays from all of us! ❄️✨
Thank you to our authors, reviewers, and readers for another great year. We look forward to welcoming your submissions in the new year!
New Open Access study by Povoleri et al. shows anti-TNF therapy boosts IL-10 in CD4+ T cells, with MAF, PRDM1 & EOMES as key TF candidates.
🔗 https://bit.ly/44LZ7TR
🎧 DSI Wrapped!
A standout year for Discovery Immunology!
Thank you to our authors, reviewers and readers for helping DSI grow its reach in 2025.
person reading posters at BSI congress
Proud to celebrate the BSI journals-sponsored Poster Prize winners! 🌟 Huge congratulations to Flavio Beke, Aisling Newing & Rébecca Barascud for their exceptional work. 🔬 More here: https://bit.ly/3MljD6r
Attending #BSI25?📣 Don’t miss AI in Publishing with Rachel Moriarty from our publisher OUP.
Explore how AI is shaping journals, research integrity & ethical practice, plus tips for using AI responsibly as an author.
🗓Today at 13:15–14:10
Attending #BSI25? 📣 Meet our Editor-in-Chief, Simon Milling!
Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Discovery Immunology. Come say hello! 👋
Discovery Immunology Call for Papers
@discovimmunol.bsky.social is inviting submissions to the BSI Congress 2025 Special Collection, highlighting research presented across this year’s meeting.
If you're contributing work at #BSI25, we encourage you to learn more and submit: oxford.ly/48M9TLd
This study shows high glucose in T2D drives senescent-like CD4+ EMRA T cells, weakening COVID-19 vaccine responses. Highlights the powerful link between metabolic health, immune ageing & antiviral immunity.
📄 https://bit.ly/48qpAXi
#Immunology #COVID19 #ImmuneAging
🛡️ This #PublishingIntegrityWeek, BSI journals are tackling papermills, promoting AI transparency, DEI & accessibility, and supporting ethical research in immunology.
Read more 👉 https://bit.ly/4odyvAZ
📢 Presenting your work at #BSI25?
Submit your paper to the Discovery Immunology Special Collection and showcase your research from BSI Congress 2025! Peer-reviewed and published together with other highlights.
Submit here: https://bit.ly/3WmPhl3
#Immunology #BSI25
🌿 How does the immune system work in the real world? Join Prof Amy Pedersen & Prof Andrea Graham for Ecoimmunology: the immune system in context.
Sponsored by Discovery Immunology. #BSI25 #Ecoimmunology