Pindolol Mitigates Cancer Cachexia by Modulating Inflammation, Lipolysis, and Muscle Atrophy Pindolol attenuates prolonged sympathetic overactivation in cancer cachexia, thereby exerting beneficial effects in a mouse model of cancer-associated cachexia.

Happy to share that part of my PhD dissertation is now published in the Journal of Biomedical and Toxicology.

Our study shows that pindolol can reduce sympathetic overactivation and improve cancer cachexia outcomes in a mouse model.

onlinelibrary.wiley.com/doi/10.1002/...

Congratulations 🎉

Interesting study and findings ✅

Thank you Jane Goodall.

A seemingly small but significant milestone.
#100citations

Dasgupta Lab is hiring! 🚀 Great opportunity, amazing mentor. Don’t miss it! @aneedasgupta.bsky.social @cancercachexia.bsky.social

Lithium deficiency and the onset of Alzheimer’s disease - Nature Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...

Researchers found brain lithium levels drop early in Alzheimer’s. In mice, Li loss worsened amyloid, tau, inflammation & memory loss. Lithium orotate restored function. Maintaining Li balance could be a new path for prevention & treatment of Alzheimer’s.

www.nature.com/articles/s41...

Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), …

The hidden secrets of adipose tissue:

Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults.
#adiposetissue
#adiposeresearch

www.sciencedirect.com/science/arti...

Vagal blockade of the brain-liver axis deters cancer-associated cachexia Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia. Blocking the right cervical vagus nerve with various invasive or non-invasive approaches alleviates cachexia, d...

Cancer cachexia drives ~1/3 of cancer deaths. In mice, cancer-induced inflammation disrupts vagal tone, impairing the brain–liver axis via HNF4α loss. Restoring vagal function slowed cachexia, eased symptoms & boosted chemo efficacy.

www.cell.com/cell/abstrac...

Histamine signaling, driven by increased histamine decarboxylase activity, contributes to muscle wasting in cancer cachexia, and inhibition of this pathway using α-fluoromethylhistidine protects against muscle atrophy in aged, tumor-bearing mice. From @jdoles.bsky.social & @aneedasgupta.bsky.social

And the biggest question is whether these drugs are truly effective in older patients and in conditions of wasting or not. Thanks to @katsufunai.bsky.social ‬for highlighting such questions.

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

In cancer cachexia, liver dysfunction drives body wasting. Researchers identified REV-ERBα as a key regulator in hepatic reprogramming. Restoring it reduced wasting by lowering harmful hepatokines—offering a new therapeutic target. #CancerCachexia #Liver #REVERBα

www.cell.com/cell/fulltex...

Congratulations

#booksky

Congratulations

Homemade Espresso and Red-bull combo summer drink 🧋🧋🧋

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

🌍 Historic first: A child with CPS1 deficiency has been successfully treated using personalized CRISPR gene editing by @ChildrensPhila & @PennMedicine.

The age of gene editing + personalized medicine has officially begun. 💊🧬

#CRISPR #Genomics #MedTwitter

www.nejm.org/doi/full/10....

This is a commendable initiative. It is our collective responsibility to spread awareness and educate others about cachectic syndrome.

CANCER CACHEXIA AWARENESS DAY = 4TH FRIDAY OF EVERY SEPTEMBER.

What emoji is Reviewer #2 going to choose? 🧐🧐

Also, you’re wearing the wrong kind of socks.

Missing your tweets! Sorry for the posts; I wasn’t aware you’re active on Bluesky.

How a New Weight-Loss Pill Could Transform Health The first truly revolutionary oral drug for obesity, made by Eli Lilly, may soon be on the way.

A new era for GLP-1 therapy?

Eli Lilly's oral drug orforglipron shows promise for weight loss & type 2 diabetes. If approved, it could be the first oral GLP-1 agonist, offering a convenient alternative to injectables like Ozempic & Mounjaro.
#obesity #GLP1

time.com/7278429/weig...

Looks like many more awards are on the horizon for GLP-1 related basic and applied research.

Congratulations to everyone involved!

Fueling up with coffee because it’s time to wrestle with my thesis. Wish me luck—I’ll need caffeine and divine intervention 😅😅

Is the PhD dream dying? Why fewer students are enrolling in doctoral programmes PhD enrolments are declining globally as financial hardships, limited job prospects, and shifting perceptions of academia deter students. Australia, Japan, Brazil, the UK, and India are witnessing a d...

Over the past five years, I’ve read many articles on the struggles of PhD researchers worldwide, yet little has changed to encourage young minds in science. I hope that one day, society will see science as a long-term investment and give it the support it deserves.

www.firstpost.com/explainers/i...

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial - Nature Aging Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive prote...

DO-HEALTH trial (777 participants) found that omega-3 (1 g/day) slowed biological aging based on DNAm clocks, with additive benefits from vitamin D (2,000 IU/day) and exercise. Over 3 yrs, aging slowed by 2.9–3.8 months, suggesting a small but good protective effect.

www.nature.com/articles/s43...

😳

BCL6, a transcriptional repressor, is crucial for maintaining muscle mass by sustaining anabolic actions of GH. This finding could lead to therapeutic strategies for preserving muscle mass and combating muscle-wasting diseases.

www.pnas.org/doi/abs/10.1...

Congratulations 🚀🚀

A feeding-induced myokine modulates glucose homeostasis - Nature Metabolism The authors identify feimin as a feeding-induced myokine that regulates glucose homeostasis via the MERTK–AKT signalling axis in mice and humans.

A newly discovered myokine, Feimin, plays a crucial role in glucose homeostasis. Secreted by skeletal muscle after feeding, Feimin binds to the MERTK receptor, promoting glucose uptake and contributing to metabolic regulation.

www.nature.com/articles/s42...