Woohoo, copick is out! Access to massive amounts of CryoET data, MCP for agentic, plus a @napari.org interface!

We even used it when hosting the CZII CryoET Kaggle competition: www.kaggle.com/competitions... when we needed to support a large collaborative annotation event with humans + ML models.

Pregnancy vaccine reduces baby hospital admissions for RSV by 80% A study confirms the vaccine gives excellent protection for babies against life-threatening chest infections.

BBC News - Pregnancy vaccine reduces baby hospital admissions for RSV by 80% - BBC News
www.bbc.co.uk/news/article...

there goes the central dogma, i guess. is nothing sacred anymore?

An illustration of an apical region of an animal cell in cross section, shown crowded with individual molecules. The plasma membrane is densely occupied by influenza virus glycoproteins, and from the surface bud influenza virions with different morphologies (L-R): spherical, bacilliform, filamentous with a genome, filamentous and empty, filamentous with a helical inner layer, and filamentous with a cofilactin cytoskeleton.

🚨New pre-print!🚨
Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles
www.biorxiv.org/content/10.6...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Thermo Fisher Scientific Cryo-EM SPA introductory mini-course (14 April, 21 April & 5 May) Learn the fundamentals of cryo-EM Single Particle Analysis (SPA) in this Cryo-EM Essentials introductory mini-course.

Part 1 was just the beginning 🚀

After the Cryo-EM SPA mini-course kickoff with @royalmicrosoc.bsky.social & ThermoFisher Scientific, don’t miss:

🗓️ Apr 21: Data Collection
🗓️ May 5: Data Processing (with Structura Biotechnology)

Register 👉 bit.ly/4cdEnrr

#cryoEM #CryoSPARC

Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS

Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab

colab.research.google.com/github/KULL-...

initial model - class 3d - post-processing

it’s been a while. Since I have no local workstation for data processing in my new role yet, I’ve been playing with AWS.

In my downtime, I asked Claude Code to follow a RELION tutorial from scratch. With a few fixes, I got a 3.22 Å result.

Not bad for AI handling routine tasks! :P

Best 3D reconstruction so far from this Tundra dataset. Right shape with some hints of secondary structure. Data collected at a higher magnification will hopefully improve this. @nusbf.bsky.social #cryoEM

Postdoc position in my lab is available.
See the below Zintellect ad if you are interested.

www.zintellect.com/Opportunity/...

In a followup with @longzhou88.bsky.social and Yue Liu we move from molecular mechanism to membrane architecture. A giant ETC-ATP synthase assembly containing 10 ATP synthases and 6 respiratory complexes builds long-range periodic OXPHOS arrays on native cristae langtaosha.org.cn/lts/en/prepr... 1/4

Chatbot-type AI has the same issue the invention of the internet had. The benefit of lots of access to information but then it immediately gets worse because it comes with no ability to filter disinformation. And then over time people game the disinformation aspect of it.

👀

Achieving Near-Atomic Resolution in Single-Particle Cryo-EM Using a Single Micrograph #cryoem

(~ 300-400 particles for apo-ferritin or 20S proteasome)

langtaosha.org.cn/lts/en/prepr...

Blender Rendering of vitrified HA trimer with DM at the air-water interface

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

Concise, clear explanation of how we know BA.3.2 is disproportionately infecting children and a quick summary of the only plausible explanation yet offered, from @solidevidence.bsky.social.

2D classes of a 58 kDa particle collected on a 100 kev Tundra electron microscope

2D classes of the 58 kDa sample collected on the 100 keV Tundra TEM with a Falcon C detector at @nusbf.bsky.social @newcastleuni.bsky.social. Still much work to do to optimise the sample & data collection but its cool to see what a 100 keV TEM is capable of. #cryoEM @recon4imd.bsky.social

This is a well balanced assessment of AI in science. It's hard to know where the balance is and it's hard to maintain that balance even if you do since it can immediately solve your problem that's due tomorrow at the tiny tiny cost of a smidgen of future skill. But it adds up.

Side-by-side ribbon diagram in coot.

Coot 1.2 released

With side-by-side stereo

and Agentic Coot

pemsley.github.io/coot/blog/20...

pemsley.github.io/coot/blog/20...

It's a big day for our team. Excited to share the launch of the Thermo Scientific™ Glacios™ 3 Cryo-TEM, our latest 200 kV #cryoEM platform. High-performance imaging with the Thermo Scientific™ READY™ System that can lower installation time and infrastructure costs.

Learn more: ter.li/alac5m

The hardest part of science is posing the right question, not answering it.

Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1

www.biorxiv.org/content/10.6...

Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen.
Thanks to @danielhurdiss.bsky.social @utrechtvirology.bsky.social #covid #pais

Added custom menus, including one to quickly add common monomers (detergents, buffers etc):

Okay so why was I the only one in the theater tonight who gasped when Ryan Gosling ran a centrifuge with two tubes in the whole thing, sitting right next to each other? Sorry was I the only scientist in the film society theater tonight??

...usually using DDM

I constantly get classes of HA's that come out like that. Will definitively check this out.

7) Using cryoET and STA we find that aldolase particles stuck at the AWI not only adopt a single orientation, but these particles are also partially denatured at the AWI! Only when aldolase particles were pushed into bulk ice with SurfACT did they remain intact.

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Finally got around to porting my coot-trimmings scripts over to Coot 1... only the hotkeys are working (nothing requiring creating a custom menu or GUI dialog), but I've added a couple of new ones, e.g. copy/pasting ligands.

Check it out & let me know what you think! 😊

github.com/olibclarke/c...

The PTA has disbanded YouTube video by codyave

youtu.be/FTlVRUkwYRI?...

The indirect — and sometimes surprising — benefits of vaccines Many vaccines confer surprising knock-on, or indirect, health benefits when they have been put into widespread use.

Multiple vaccines offer benefits beyond protecting the vaccinated individual from the disease the vaccine targets. Some protect fetuses in the womb, some protect people who are immunocompromised, some protect seniors. As vax rates fall, these benefits are threatened. www.statnews.com/2026/03/19/v...