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Posts by Laura Suttenfield

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Wolbachia uses ankyrin repeats to target specific fly proteins | mBio Molecular interactions drive co-evolutionary arms races between hosts and pathogens. These interactions shape the structure and function of both host and parasite proteins, enabling immunity or virule...

Extremely proud of my student Will Hamilton and the work we've done to characterize Wolbachia ankyrin repeat proteins. TLDR: they do interact with specific Drosophila proteins! journals.asm.org/eprint/KXVNI...

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Omg Lilian I am so excited for you! Congratulations on your position and I hope to see you again sometime soon 🙌☺️⭐️💃🏻🐝

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Interested in joining the lab or collaborating? I’d love to hear from you! You can use my current website as a reference (liliancaesar.com) - Caesar Lab version coming soon 😊

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I am thrilled to share that this fall I’ll be joining the University of Oklahoma School of Biological Sciences (@ou.edu) as an Assistant Professor! The Caesar Lab will study the ecology and evolution of host-microbiome interactions in social bees (honey bees, stingless bees and more) 🦠🐝

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Pls share: Postdoc position in Dept of Micro & Immun, Indiana U. School of Med, focused on how Lyme disease pathogen uses 2nd-messenger signaling to survive & establish persistent infection in mammalian host & the tick vector. Applicants: send CV to xfyang@iu.edu or contact Dr. Frank Yang.

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Don't forget to submit your abstract to MEEHubs2026: Aug 3-5, 2026

meehubs.org

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Dan Weinberger and I @yalesph.bsky.social are hiring multiple research positions in microbial/virus sequencing and bioinformatics workflows with respiratory pathogens, including Streptococcus pneumoniae, Mycobacterium tuberculosis, RSV, and/or hMPV.

See 👉 forms.gle/xpmzTtNqHFqK...

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Great read, thanks for sharing!

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I’m so glad you said something, I was just seeing that in my email today as well after previously having it off… ☹️

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Announcing Seattle DROP: Discover Research Opportunities for Postdocs on May 5th

Interested in postdoc opportunities in Seattle, WA? Seattle DROP is a virtual biomedical postdoc recruitment event sponsored by @fredhutch.org, @uwnews.uw.edu, and @seattlechildrens.org on May 5th from 8 AM-1 PM PT.

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Metagenomic strain-resolved DNA modification patterns link extrachromosomal genetic elements to host strains www.biorxiv.org/content/10.64898/2026.03...

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Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social

Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback.

rdcu.be/famFj

3 weeks ago 98 56 4 1

Hi, Blue Sky phage enthusiasts @phagepapers.bsky.social! My lab has been busy cooking up some cool phage science that is all out now on BioRxiv, so I am here to share with you:

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Species-specific prophage induction by ciprofloxacin in human gut metagenomes Antibiotics are known to trigger prophage induction in controlled laboratory settings, but it remains unclear whether this also occurs within microbiomes in nature. Current methods investigating the link between antibiotics and prophage induction within the human gut rely on in vitro culturing of human gut bacterial isolates. Using a metagenomic approach, we aimed to measure prophage induction and whether it is associated with antibiotic exposure. Across two independent human cohorts, we compared prophage to bacterial host read depth ratios (P:H) across known or measured antibiotic exposures. We found that induction is not broadly associated with antibiotic exposures at the level of the overall microbiome, but that ciprofloxacin increases P:H ratios in specific bacterial species. We documented heterogeneous trajectories of P:H ratios over the course of antibiotic exposure, sometimes increasing and remaining high, or returning to baseline. This study complements experimental models by providing in vivo evidence of induction in the human gut. Importance Bacteriophages are viruses that infect a bacterial host. The lytic and lysogenic cycles are the two classic outcomes of phage infection. In the lytic cycle, the phage immediately replicates and lyses its host to release new viral particles. In the lysogenic cycle, the phage, now called a prophage, integrates its genome into that of its host without killing it. Prophages can switch to the lytic cycle in a process called induction, in which the viral genome is replicated, the host cell is lysed, and viral particles are released. The most immediate consequence of induction is host cell death which can impact bacterial populations and communities. Since prophages are mobile genetic elements that can move between bacteria, they are also an important vehicle for horizontal gene transfer. While induction has been well studied in vitro , whether and how induction occurs within the complex microbial ecosystem in humans is less well characterized. Understanding prophage induction in vivo is therefore critical in corroborating in vitro observations. ### Competing Interest Statement The authors have declared no competing interest. NIH Common Fund, https://ror.org/001d55x84 Natural Sciences and Engineering Research Council

In the lab, antibiotics can make integrated viruses (prophages) pop out of bacterial genomes. In this (short!) preprint, we asked a simple question: how much does this happen outside the lab, in the human gut?

TLDR: Not much overall, in specific bacterial species.
🧵

www.biorxiv.org/content/10.6...

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Let's figure out a way to add forwards on whatsapp to your google scholar profile :)

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While writing my PhD thesis (2020), I was told not to worry - no one besides the committee would read it. Today I learned it’s widely shared by beekeepers in WhatsApp groups in Brazil. I knew about the manual I wrote for this purpose, but not the thesis. Happy to see it being useful beyond academia!

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#OnThisDay in 1938, American evolutionary biologist Lynn Margulis was born. Margulis is most known for developing and popularising the endosymbiotic theory, which explains how eukaryotic cells evolved organelles from simpler prokaryotic organisms that resided within another and became incorporated.

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Happy 38th birthday to the #LTEE!
#BOTD in 1988.
Keep on evolving!

#science #evolution #microbiology

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Check out the latest from @cathyhernandez.bsky.social, where she shows that prophage activity underlies intraspecific variation in thermal tolerance AND evolutionary rescue in response to extreme temperature challenge.

This is one for prophage peeps and climate change peeps.

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Excited to share a preprint of work from my postdoc with @paulturnerlab.bsky.social exploring how prophages can impact host thermal ecology and evolution. www.biorxiv.org/content/10.6...

2 months ago 34 9 1 3

Next one in a storm of preprints from our lab's amazing scientists.. Recent-ex-postdoc, #newPI @cathyhernandez.bsky.social studied thermal ecology of marine bacteria isolated near New Haven. Turns out, response of this bacterium to temperatures is shaped by prophages!

#phagesky #microsky

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Cancer therapies exploit DNA repair defects to kill tumours. We asked whether the same logic could constrain antibiotic resistance evolution...

www.biorxiv.org/content/10.6...

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MENI is back! Join us in Dublin this August 2026 for our 3rd Meeting for Microbial Evolution in Ireland. We are delighted to have @rachelmwheatley.bsky.social @drrebeccajhall.bsky.social @jpjhall.bsky.social and @tweethinking.bsky.social join us as keynote speakers this year. miniurl.com/MENI

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SFI External Professor Santiago Elena elected to the American Academy of Microbiology SFI External Professor Santiago Elena has been elected as a fellow of the American Academy of Microbiology, joining 62 other fellows in the class of 2026, each selected for their contributions in the ...

SFI’s Santiago Elena has been elected a fellow of the American Academy of Microbiology.

He joins 62 fellows in the 2026 class. His work explores how RNA viruses adapt to hosts and manipulate cellular resources. Since joining SFI in 2008, he has organized several working groups on virus evolution.

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I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.

2 months ago 56 96 1 0
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Co-occurrence is associated with horizontal gene transfer across marine bacteria independent of phylogeny Abstract. Understanding the drivers and consequences of horizontal gene transfer (HGT) is a key goal of microbial evolution research. Although co-occurring

Now out & nicely formatted in @isme-microbes.bsky.social

A big analysis of ocean genomes & metagenomes co-led by former postdocs, now PIs, @gmdouglas.bsky.social & @cyanophage.bsky.social along with co-PIs @lbobay.bsky.social & Samuel Chaffron.

A few highlights... 🧵 (1/n)

doi.org/10.1093/isme...

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congrats all! 🤩 🦠

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The hidden energy cost of cellular dormancy Many organisms survive harsh environments by switching into special survival modes. Some bacteria do this by forming spores—dormant, highly resilient cells that can persist for years or even centuries...

www.growkudos.com/publications...

New work with @ckarakoc.bsky.social and @shoestrapped.bsky.social in @pnas.org

2 months ago 25 14 1 0

Congrats Lily! 👏

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Our new paper and associated blog post were published today! And @biancanogr.bsky.social and @diemq.bsky.social finally made bsky accounts so I could tag them.

This is Bianca's paper from our lab and DiemQuynh's first ever.

I'm so happy to have this review out finally!

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