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Posts by IBDM, Institut de Biologie du Développement de Marseille

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Our institute was delighted to welcome journalists from AJSPI to discuss our research 🧪 We study how organs form — from molecular, cellular and physical building blocks to disease mechanisms affecting the brain, heart, intestine, muscle, reproductive system and pain. Interdisciplinarity is key! 🔬

1 week ago 7 2 1 0

@ajspi.bsky.social @bentonson.bsky.social @cynthia-lab.bsky.social

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@cnrs-dr12.bsky.social @univ-amu.fr

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With Fanny Mann, @cedricmaurange.bsky.social, Aziz Moqrich, Sébastien Poulain, @pflenne.bsky.social, @ovarylab.bsky.social, @axonreg2lab.bsky.social, Benjamin Prud’homme and @blibep.bsky.social.

1 week ago 2 0 1 0

Thanks to Pierre Kaldy, Nathalie Picard, Benoît Tonson, Cynthia Laboureau, Alexandra Verbecq Van der Borgh, Jérémie Bazart, Katia Delaval and Quentin Benoist for the rich discussions. We hope you enjoyed your stay in Marseille!

1 week ago 1 1 1 0
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Our institute was delighted to welcome journalists from AJSPI to discuss our research 🧪 We study how organs form — from molecular, cellular and physical building blocks to disease mechanisms affecting the brain, heart, intestine, muscle, reproductive system and pain. Interdisciplinarity is key! 🔬

1 week ago 7 2 1 0
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Sunny hike to Sugiton to welcome @noemimonferini.bsky.social, our new postdoc, and Maha Gammoudi, our new Master’s student! ☀️⛰️🌊 Happy to have you both on the team!

1 week ago 13 3 1 1

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Médaille de bronze 2025 : Sham Tlili, décrypter les lois physiques de la formation des tissus
Médaille de bronze 2025 : Sham Tlili, décrypter les lois physiques de la formation des tissus YouTube video by CNRS

🎥 Our researcher @shamtlili.bsky.social explores the physical laws governing tissue formation in this video, following the CNRS Bronze Medal she received last year 🏅

www.youtube.com/watch?v=-22F...

2 weeks ago 15 5 0 1
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A pleasure to welcome Nikolaos Konstantinides from Institut Jacques Monod today. 🪰🧠 A great talk on the evolution of neurodevelopmental mechanisms in the insect visual brain, with amazing omics data spanning more than 400 million years of insect evolution. 🧬

2 weeks ago 8 2 1 0
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We will have the pleasure of welcoming @manuelthery.bsky.social from @cea.fr to Luminy, Marseille as a keynote speaker.

🕧 Friday 17th April 2026, 11:30, Amphi 12
🔬 From Morphogenesis to Space Partitioning by Microtubules and Motors

Save the date! 🙌

2 weeks ago 18 7 1 1

@cnrs-dr12.bsky.social @univ-amu.fr.web.brid.gy @centuri-ls.bsky.social

2 weeks ago 1 0 0 0
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We will have the pleasure of welcoming @manuelthery.bsky.social from @cea.fr to Luminy, Marseille as a keynote speaker.

🕧 Friday 17th April 2026, 11:30, Amphi 12
🔬 From Morphogenesis to Space Partitioning by Microtubules and Motors

Save the date! 🙌

2 weeks ago 18 7 1 1

@cnrs-dr12.bsky.social @univ-amu.fr @neuromarseille.bsky.social @centuri-ls.bsky.social

2 weeks ago 1 0 0 0
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A pleasure to welcome Nikolaos Konstantinides from Institut Jacques Monod today. 🪰🧠 A great talk on the evolution of neurodevelopmental mechanisms in the insect visual brain, with amazing omics data spanning more than 400 million years of insect evolution. 🧬

2 weeks ago 8 2 1 0
Médaille de bronze 2025 : Sham Tlili, décrypter les lois physiques de la formation des tissus
Médaille de bronze 2025 : Sham Tlili, décrypter les lois physiques de la formation des tissus YouTube video by CNRS

🎥 Our researcher @shamtlili.bsky.social explores the physical laws governing tissue formation in this video, following the CNRS Bronze Medal she received last year 🏅

www.youtube.com/watch?v=-22F...

2 weeks ago 15 5 0 1

Photo credits: Céline Wilczynski & Anne Haguenauer

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Sham Tlili | Délégation Provence et Corse du CNRS Pour suivre ces transformations sans les altérer, elle a adapté aux organoïdes embryonnaires des techniques comme la microscopie biphotonique. Cela permet de visualiser l’intérieur des tissus en profondeur, avec peu de lumière.

👉 To learn more about her work (in French): www.provence-corse.cnrs.fr/fr/personne/...

2 weeks ago 0 0 1 0

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Happy New Year 2026!

This year, Hadi Boukhatmi, Régis Giet and I are delighted to be organising the 36th French Droso Meeting in Brittany, from 5 to 8 October.
A great line-up of speakers

Mark the date in your diaries !

The meeting website containing all the details will be opening very soon.

3 months ago 20 14 0 1
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March also means Brain Awareness Week — the 28th edition in 2026! 🧠 Our researchers and students visited schools across the Aix-Marseille-Provence area to share how the brain works, explore neurons, and introduce neuroscience careers to pupils from primary school to sixth form. 🏫🔬🙌🏼

3 weeks ago 4 2 0 0
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An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator. New study from Camille Boutin @camboutin.bsky.social, Laurent Kodjabachian @ibdm.bsky.social @univ-amu.fr and colleagues: rupress.org/jcb/article/...

#Cilia #Technology #Development

1 month ago 9 4 0 0

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We developed a new cell line that will greatly advance our understanding of #multiciliated cells. With this ressource and thanks to a great collaboration with Jean-Paul Borg, Stéphane Audebert and Luc Camoin we assembled the first MCC proteome;

2 months ago 1 1 1 0
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In @jcb.org, @camboutin.bsky.social, Kodjabachian et al. @ibdm.bsky.social describe an inducible multiciliated cell line well suited for advanced #microscopy and #proteomic approaches. The study provides a detailed proteomic profiling of MCC during their differentiation. rupress.org/jcb/article/...

2 months ago 3 2 0 0
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@camboutin.bsky.social, Kodjabachian et al. @ibdm.bsky.social describe an inducible multiciliated cell line well suited for advanced #microscopy and #proteomic approaches. The study provides a detailed proteomic profiling of MCC during their differentiation. rupress.org/jcb/article/...

#Cilia

2 months ago 9 4 0 0
System-level regulation of hierarchical transitions in a tumour lineage The fundamental principles defining how cell state transitions are regulated along a tumour lineage to determine its cellular composition remain unclear. Here, we investigate how such transitions are controlled in a reductionist hierarchical brain tumour model. Quantitative analysis of 3D transition maps revealed that the differentiation of cancer stem cells (CSCs) into transit amplifying progenitors (TAPs) depends on the identity of their immediate neighbours. This is embodied in a transition rule that quantitatively predicts the probability to differentiate as a function of the proportion of TAP neighbours. Integrated into 3D simulations of tumour growth, this rule spontaneously recapitulates spatial segregation of CSCs in clusters and their stable proportion. We further show in vivo that CSC clustering protects the CSC pool from depletion driven by TAPs. We identify an EGFR-mediated relay mechanism that propagates the CSC-to-TAP transition across CSC clusters. In CSCs, the LRIG1-like EGFR inhibitor Kekkon1 dampens this propagation, ensuring continuous replenishment of the CSC pool. Collectively, these findings show how local fate regulation drives emergent segregation which in turn constrains CSC differentiation dynamics. This provides a conceptual framework to understand and exploit the tumour’s intrinsic differentiation potential by manipulating the determinants of its system-level features. ### Competing Interest Statement The authors have declared no competing interest. Turing Centre for Living Systems (CENTURI) La Ligue Contre le Cancer, https://ror.org/00rkrv905, Equipe Labellisée LIGUE 2025 Fondation pour la Recherche Médicale, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Agence Nationale de la Recherche under the France 2030 program, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Centre South-ROCK, INCa-Cancer_18695

Tumours aren’t just a messy mix of cells—they’re highly organised and hierarchical societies!
Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. 🧵👇

2 months ago 17 7 2 0
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Super happy to share the exciting work of Emma Legait, showing how neighbourhood composition determines cancer stem cell fate in hierarchical tumours. A great and long-standing collaboration with @cedricmaurange.bsky.social

www.biorxiv.org/content/10.6...

2 months ago 14 6 1 0
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