JAMA Psychiatry Review titled "Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review" by Diana K. Orsini et al. It discusses functional unblinding in trials and its impact, noting the need for standardized measures.

Functional unblinding was common in most psychedelic randomized clinical trials for psychiatric disorders, with >70% correctly identifying treatment allocation, raising concerns for trial validity.

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Response appropriateness across product versions shown in bar graphs and forest plot. GPT-5 Auto, GPT-4o, and Free models are compared with consensus ratings for control and psychosis. Within-version proportional odds analysis given.

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis.

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Three scatter plots show overall bias versus BPRS scores for people with bipolar disorder (BD), schizophrenia (SZ), and healthy controls (HCIs). The top left graph is labeled "A" and titled, "Overall bias and BPRS Mania domain score in people with BD and people with SZ."

Serial bias in spatial working memory differed by group, with patients with schizophrenia showing repulsive bias, most healthy controls showing attractive bias, and individuals with bipolar disorder demonstrating mixed patterns.

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Figure 1. Voxel Placement, Glutamate Levels. A: T1-weighted MRI shows medial prefrontal cortex voxel location. B: Glutamate levels in institutional units among control, FEP, Schizophrenia groups. FEP and Schizophrenia groups have higher glutamate levels than control.

First-episode psychosis was marked by elevated medial prefrontal glutamate levels compared with chronic schizophrenia and controls, with higher glutamate associated with lower verbal and visual learning scores. ja.ma/4vuGPRW

JAMA Psychiatry info-graphic on RCT: Mirtazapine for Methamphetamine Use Disorder. Population: 213 Male, 126 Female. Intervention: 344 Participants randomized. Findings: Mirtazapine group showed greater reduction in methamphetamine use. Settings: 6 clinics in Australia.

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns.

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A JAMA Psychiatry ad: 'Call for Applications: Editorial Fellowship,' with a deadline of April 15, 2026. A hand writes in a notebook with a pen. A button reads, 'Learn more >'

⏰ Last call!

Applications for the JAMA Psychiatry Editorial Fellowship Program are due Wednesday, April 15.

🔗Learn more and apply here: ja.ma/4sve7xL

The image presents clock-drawing tests with varying MoCA scores(2-16), education levels(5th-college), ages(35-67), and years hospitalized(7-46). Drawings range from incomplete circles with few numbers to more accurate clock faces, reflecting cognitive abilities.

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/47QhSpZ

The image shows two US maps displaying state variations in Medicaid beneficiary service use for inpatient psychiatric care in 2023. Map A shows "Inpatient psychiatric discharges," while Map B shows "Inpatient days for psychiatric care."

From 2014 to 2023, Medicaid paid for a rising share of US inpatient psychiatric care, with urban hospitals seeing consistently higher Medicaid coverage than rural hospitals by 2023.

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Box. Sleep and Circadian Rest-Activity Parameters: includes Sleep Onset and Wake-Up Time, Sleep Period Time (SPT), Wake After Sleep Onset (WASO), Total Sleep Time (TST), Sleep Efficiency, Midsleep Phase (MSF), Sleep Regularity Index (SRI)@39, Composite Phase Deviation (CPD)@40, Activity L5 and M10@41, Relative Amplitude of Activity (RA)@41

Actigraphy-derived measures of sleep phase variability and activity amplitude identified individuals at higher risk of relapse in #Depression, supporting their potential as scalable biomarkers in ongoing monitoring. ja.ma/4mo5544

🎧 Listen to this interview with Hemant Bhargav, MD, PhD, author of Yoga for Opioid Withdrawal and Autonomic Regulation: A Randomized Clinical Trial.

Hosted by John Torous, MD.

JAMA Psychiatry info-graphic on RCT: Mirtazapine for Methamphetamine Use Disorder. Population: 213 Male, 126 Female. Intervention: 344 Participants randomized. Findings: Mirtazapine group showed greater reduction in methamphetamine use. Settings: 6 clinics in Australia.

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns.

ja.ma/4vjX4kL

Heat maps and line graphs display EEG spectral profiles during ketamine/placebo infusions. Subplots A-C show frequency vs. minutes in ketamine infusion. D-F chart fold power change over time. G-I show mean amplitude for different infusions.

Administration of ketamine during general anesthesia preserved high-frequency EEG changes but lacked low-frequency modulation, suggesting neurophysiologic components of ketamine can be selectively altered. ja.ma/4czqVOA

JAMA Psychiatry ad: "Call for Applications: Editorial Fellowship," application due April 15, 2026. A person writes in a notebook. Button: "Learn more >"

📢 Applications are open for the @jamapsychiatry.com Editorial Fellowship Program!

Early-career psychiatrists or doctorate level clinicians with an interest in medical publishing and editorial processes are invited to apply.

🔗ja.ma/4c4R5HN

Earlier #ADHD diagnosis was associated with higher school performance, more academic educational track selection, and reduced risk of school dropout, while later diagnosis indicated greater dropout risk. ja.ma/4sTLI5f

Response appropriateness across product versions shown in bar graphs and forest plot. GPT-5 Auto, GPT-4o, and Free models are compared with consensus ratings for control and psychosis. Within-version proportional odds analysis given.

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis.

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Clock drawing test results from schizophrenia patients. Each drawing varies greatly, some with missing numbers, distorted shapes, or nonsensical arrangements. MoCA scores, education levels, ages, and years hospitalized are listed for each.

Among individuals with #Schizophrenia and co-occurring #SubstanceUseDisorders, psychological and psychosocial interventions showed limited benefit for symptom reduction and no effect on substance use, except for nicotine. ja.ma/4bWrpye

JAMA Psychiatry ad: "Call for Applications: Editorial Fellowship." Due April 15, 2026. A hand holds a pen over a notebook. A button reads, "Learn more >"

JAMA Psychiatry is recruiting early career clinicians for a 2-year editorial fellowship.

Gain hands-on experience with peer review, participate in editorial discussions, and complete a personalized editorial project.

🔗 ja.ma/4t7ValT

Figure 2: Societal Costs of Schizophrenia in the US in 2024. Chart A shows domain-level totals; health care, disability benefits, housing, justice, quality of life, employment, lifespan, caregiver wages/impact. Chart B is a tornado diagram for sensitivity analyses of model parameters.

The 2024 US societal cost of #Schizophrenia was $366.8 billion, with unpaid caregiving, lost wages, and reduced quality of life accounting for over 75% of total costs. ja.ma/4tnIU04

JAMA Psychiatry: RCT: A Ketogenic Diet for Treatment-Resistant Depression. Population: 26 men, 61 women, 1 nonbinary, mean age 42.1. Intervention: 88 participants randomized, 44 ketogenic diet group, 44 phytochemical group. Graph showing PHQ-9 score vs time since randomization.

A 6-week #KetogenicDiet produced modest improvement in depressive symptoms vs control in adults with #TreatmentResistantDepression, with no difference in secondary outcomes and uncertain clinical relevance. ja.ma/4sTC96t

Table titled: Patient-Centered Approach to Exploring Artificial Intelligence (AI) Use for Mental Health. Columns: Step, Example language and tasks. Steps include Normalize and ask, Explore benefits, Explore concerns, Offer information with permission, Invite ongoing dialogue.

More than 10% of US youth and nearly half of adults with mental health conditions turn to generative AI for advice or support, highlighting the need for clinicians to routinely ask about #AI use in mental health care.

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The image presents clock-drawing tests with varying MoCA scores(2-16), education levels(5th-college), ages(35-67), and years hospitalized(7-46). Drawings range from incomplete circles with few numbers to more accurate clock faces, reflecting cognitive abilities.

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/4bWZlcz

JAMA Psychiatry info-graphic on RCT: Mirtazapine for Methamphetamine Use Disorder. Population: 213 Male, 126 Female. Intervention: 344 Participants randomized. Findings: Mirtazapine group showed greater reduction in methamphetamine use. Settings: 6 clinics in Australia.

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns.

ja.ma/4dVjpPd

JAMA Psychiatry ad: "Call for Applications: Editorial Fellowship." Due April 15, 2026. An arm holds a pen over a notepad. A button reads, "Learn more >"

📢 Now accepting applications: JAMA Psychiatry Editorial Fellowship

Early-career psychiatrists or doctorate-level clinicians are invited to apply for this opportunity to gain hands-on training in the editorial processes and policies of a peer-reviewed psychiatry journal.

🔗 ja.ma/40Hh1Uw

This meta-analysis found no clinically meaningful difference between #psychedelic-assisted therapy (#PAT) and open-label traditional #antidepressants (#TADs) for patients with major #depression.

🎥 Watch the video and read the full article:

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Figure 1, titled "Translational Deep Phenotyping Reveals a Multivariate Phenotype Brain Signature of Cognitive Impairments in Schizophrenia (SCZ) That Is Associated With the Genetic Risk," shows study overviews, brain patterns and cognition scores.

Individual variability in synaptic gene expression & synapse density in induced pluripotent stem cell-derived neurons predicted macro-scale alterations in gray matter volume and gamma-band activity in patients w/ #Schizophrenia.

#SIRS2026 @sirsofficial.bsky.social

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Response appropriateness across product versions shown in bar graphs and forest plot. GPT-5 Auto, GPT-4o, and Free models are compared with consensus ratings for control and psychosis. Within-version proportional odds analysis given.

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for #psychosis.

ja.ma/4bKyvVc

Figure 2, "Study Design", shows a birth cohort and investigation schematic regarding methylphenidate for ADHD. Chart A displays birth years 1987-1997 against follow-up years. Chart B diagrams baseline confounders, hospital levels, and psychosis diagnosis over 1-4 years.

In children and adolescents with #ADHD, sustained methylphenidate treatment was not associated with increased risk of #Psychosis, and may be protective for those diagnosed in childhood.

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JAMA Psychiatry banner: "Call for Applications: Editorial Fellowship, Due April 15, 2026." A hand holds a pen over a notebook. A button says "Learn more >".

JAMA Psychiatry is recruiting early career clinicians for a 2-year editorial fellowship.

Gain hands on experience with peer review, participate in editorial discussions, and complete a personalized editorial project.

🔗 ja.ma/4rIuV3A

JAMA Psychiatry info sheet. RCT: GH001 vs Placebo in Patients With Treatment-Resistant Depression. Population: 35 Male, 46 Female. Intervention: 81 patients randomized, 40 inhaled mebufotenin (GH001), 41 inhaled placebo. Findings: graph showing change from baseline.

Among adults with #TreatmentResistantDepression, single-day inhaled GH001 resulted in rapid, significant symptom reduction and remission vs placebo, with no severe adverse events and sustained effects over 6 months.

ja.ma/3Nme5ty

JAMA Psychiatry ad: "Call for Applications: Editorial Fellowship." Due April 15, 2026. A hand holds a pen over a notepad. Button reads "Learn more >".

📢 Applications are open for the @jamapsychiatry.com Editorial Fellowship Program!

Early-career psychiatrists or doctorate level clinicians with an interest in medical publishing and editorial processes are invited to apply.

🔗Learn more & apply here: ja.ma/40Hh1Uw