Happy to share our work on RPA exhaustion activating SLFN11 published in @natcellbio.nature.com today!

‼️ Excited to share our new paper out now in @science.org ‼️

We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.

Link: www.science.org/doi/epdf/10....

Thread ⬇️ (1/8)

SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres The tRNA nuclease SLFN11 is epigenetically silenced in ~50% of treatment-naive tumours and is the strongest predictor of chemoresistance but why it is frequently inactivated in cancer is unknown. To a...

🚀 New preprint alert!

We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis.

📄 Read the manuscript here: www.biorxiv.org/content/10.1...

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...

1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filamen...

NEW in @science.org, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost! #ScienceResearch science.org/doi/10.1126/... (1/7)

Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.

Check out our new paper here www.nature.com/articles/s41... + movie

On the left is the structural output from the AlphaFold 3 server colored by pLDDT, which requires structural knowledge for interpretation. On the right is the AlphaBridge ring output, where the results are pre-analyzed and visually presented, making them easier to understand.

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Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts.

➡️ Let AlphaBridge help you accelerate your workflow!

❤️ Share and try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...

Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability - Nature Communications DNA repeats can lengthen or shorten during their replication, which may lead to a human disease. Here, the authors discovered that an essential replication protein, Mcm10, counteracts instability of G...

Another week, another great paper! Kudos to the amazing grad student, Chiara Masnovo who single-handedly initiated and led the project, and arranged a terrific collaboration with the Aharoni lab from Ben-Gurion University, and to the great members of the two labs.

www.nature.com/articles/s41...?

The histone H3-H4 tetramer is a copper reductase enzyme A eukaryotic histone complex can package DNA but is also a cupric reductase that provides biousable Cu1+ for the cell.

H3-H4 histone dimers act as copper reductase. This is important because ETC and SOD1 require bio-usable Cu+ for function. This article shows a new mechanism by which chromatin histones can affect the cell metabolism via a new role in metal processing #redoxepigenetics www.science.org/doi/10.1126/...

RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at

New at NAR Cancer: Ex vivo functional test for HR proficiency applied to a cohort of ovarian cancer PDX models: a way to identify PARPi-sensitive tumors lacking BRCA1/2 alterations. From Francien Talens et al., Univ of Groningen. academic.oup.com/narcancer/ar...

Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...

“In this Review, we discuss #telomere protection, maintenance and damage. We highlight the differences between #human and #mouse telomere biology that may contribute to discrepancies between human #diseases and mouse models.” #telomerase #aging
www.nature.com/articles/s41...

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1 The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslink

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability www.biorxiv.org/content/10.1101/2024.11....

Behind the graduate mental health crisis in science - Nature Biotechnology Survey results identify how scientific research and teaching contribute to the graduate student mental health crisis.

"Negative reinforcement, such as receiving overly harsh criticism or being scolded by a research mentor, and being held to unreasonable expectations were two of the most detrimental aspects of research affecting student mental health."

www.nature.com/articles/s41...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social.

Check out the original paper in Cell here:
www.cell.com/cell/fulltex...

Here's a summary thread from "the other site": x.com/PeterLyLab/s...

World AIDS Day: Advances in HIV prevention and treatment

We invite anyone interested in HIV research to our event marking #WorldAIDSDay.

We’ll hear from five expert speakers, including our own Anabel Guedan, with experience in HIV research, clinical trials, policy and activism.

📅 Friday 29 Nov
🕑 14:15-18:30

www.crick.ac.uk/whats-on/wor...

E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that...

My first post on BlueSky.

Our latest review delves into the critical roles of ubiquitin E3 ligases in safeguarding genome integrity and their implications in human diseases.
@drjhujh.bsky.social @profstewartlab.bsky.social
portlandpress.com/biochemj/art...

GS II is here! Please follow the newly arrived folks, and comment/DM to be included!
go.bsky.app/VeCmq6

Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell!

We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.

Great teamwork by Diana, Marta and Paula!

www.cell.com/cell/fulltex...