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RESEARCH PAPER: Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation
By Samajdar et al. and Luis Batista
➡️ https://ow.ly/Ko1u50YyStI

Huntsman Cancer Institute
#transcription #telomerase #telomere

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosteron...

#Article in #MedComm

A Novel #Peptide, #HS1002, Enhances #Antitumor Activity via Dual Targeting of the #GnRH Receptor and Human #Telomerase Reverse Transcriptase in Prostate Cancer Cells doi.org/10.1002/mco2...

Research team from Sungkyunkwan University

#hTERT #ImmuneResponse #ProstateCancer

Here you can see the cryoEM structure of the H/ACA RNP protomer of human telomerase dimer (PDB code: 9QB2)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #telomerase #complex #promoter #dimer

Schematic model of telomerase reactivation in non-HBV-associated hepatocellular carcinoma. CTCF binds to the TFAP4 promoter and increases TFAP4 expression. TFAP4 then binds directly to the TERT promoter, enhancing TERT mRNA transcription. Increased TERT expression leads to elevated telomerase activity and stabilization of telomeres. Ethanol exposure further upregulates TFAP4 and TERT in non-HBV HCC cells, while this regulatory pathway appears limited in HBV-associated HCC.

📘 CHP Archive Spotlight #08
Original Research (2024) | Lim et al.
TFAP4 directly reactivates TERT in non-HBV HCC — independent of promoter mutation.
CTCF → TFAP4 → TERT axis drives telomerase activation, especially in alcohol-related tumors.
🔗 doi.org/10.47248/chp...
#HCC #TERT #Telomerase

Elizabeth Blackburn, wearing glasses and a pearl necklace, looks slightly off-camera. The text highlights her Nobel Prize win for discovering the enzyme telomerase. "#FamousScientists" appears at the top with logos in the corners.

Elizabeth Blackburn won a Nobel Prize for discovering telomerase, an enzyme that protects chromosomes and could unlock secrets to aging and cancer prevention! 🧬🙌 #FamousScientists #Telomerase #WomenInSTEMl

I am excited to begin a #Sabbatical at @ki.se (Genander Lab).
We are expanding our #zebrafish findings (PMID: 37142828, 40490553) to human #organoids to study #cGAS-#STING #inflammation and #telomerase rescue in the #GI tract. 🧬🩺
Special thanks to @EMBO.org @cnrs.fr for the support. #Aging #TBDs

Dr. Paul Lorigan and colleagues report that for patients with treatment naïve advanced #melanoma, the addition of the #telomerase vaccine, UV1, to ipilimumab-nivolumab did not result in improved efficacy compared with ipilimumab-nivolumab alone. 💊

🆕 https://bit.ly/45VXt1t

Okayama University Seeks Approval for Innovative Cancer Treatment with Oncolytic Virus Therapy Okayama University has applied for regulatory approval of Telomerase, a groundbreaking oncolytic virus treatment for esophageal cancer, potentially transforming patient care in Japan.

Okayama University Seeks Approval for Innovative Cancer Treatment with Oncolytic Virus Therapy #Okayama_University #Telomerase #Oncolys_Biopharma

🌟G&D SPOTLIGHT 🌟

REVIEW: CST–Polα/Primase: the second telomere maintenance machine
By Sarah Cai and Titia de Lange
➡️ genesdev.cshlp.org/content/37/13-14/555.abs...

#telomere #telomerase #strandsynthesis #polymerase⍺ #primase

Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes Telomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the Caenorhabditis elegans telomerase RNA component 1 (terc-1), as t...

An international team led by Hiroki Shibuya (Lab for Gametogenesis) discover that a long-elusive #telomerase RNA in #Celegans hitchhikes in the introns of a germline-expressed gene and in turn unveils a previously unknown way to ensure species survival.
In @science.org
doi.org/10.1126/scie...

#ElizabethBlackburn #CarolGreider #JackSzostak. #telomeres #Telomerase #python #py5 #digitalart #digitalnotreallyart
#ScienceUnderAttack #NobelPrize #AcademicFreedom

Lobsters: The Immortal Sea Gangsters

Lobsters: The Immortal Sea Gangsters

#Lobsters #Immortality #Aging #Biology #Telomerase

sciencehumor.io/biology-memes/lobsters-t...

Evolutionarily conserved role of telomerase reverse transcriptase in programming the microenvironment via regulation of the cGAS–STING pathway - Nature Cell Biology Akincilar, Fidan et al. report a conserved role for telomerase reverse transcriptase in regulating inflammation via the cGAS–STING nucleic acid-sensing pathway in myeloid cells, independent of its tel...

💫NEW: Akincilar, Fidan et al. report a conserved role for #telomerase reverse transcriptase in regulating #inflammation via the cGAS–STING nucleic acid-sensing pathway in myeloid cells, independent of its telomerase activity.
👉https://rdcu.be/eBB96
bit.ly/45sOTYv

The Biological Structure of an Immortal Human: A Scientific Exploration - Biological immortality has always been a fascinating dream, captivating the imagination of ... www.myscrappydays.com/news.php?slu... #Biologicalimmortality #Humanstructure #Cellularregeneration #Telomerase #Immunesystem

Why don't bats get cancer? Researchers discover protection from genes and strong immune systems A study to look at why long-lived bats do not get cancer has broken new ground about the biological defenses that resist the disease.

"bats have superpowers allowing them to live up to 35 years, which is equal to about 180 human years, without cancer." ... "two copies of p53 and has elevated p53 activity compared to humans." ... "telomerase, is inherently active in bats," phys.org/news/2025-06... #p53 #telomerase #biology

The functionality of telomerase depends on CPF–CF induced 3′end processing of its RNA component TLC1 and a novel Nrd1–Nab3 surveillance mechanism Abstract. Telomere elongation is driven by telomerase, which consists of several proteins and the ncRNA component TLC1 in yeast. While many ncRNAs are term

Interesting!
#TLC1 #Telomerase #RNA #Yeast

academic.oup.com/nar/article/...

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and ce...

Our latest preprint!
We show that telomeric antisense oligonucleotides alleviate premature #aging in #telomerase mutant #zebrafish. A collaboration with the labs of Fabrizio d'Adda di Fagagna and Marina Mione.
Congrats Bruno for his first corresponding author paper!👏
www.biorxiv.org/content/10.1...

Telomerase: The Gym Bro Of Cellular Biology

Telomerase: The Gym Bro Of Cellular Biology

#Telomerase #Biology #Dna #Cellular #Aging

sciencehumor.io/biology-memes/telomerase...

Happy birthday to Carol W. Greider! She received a #LaskerAward for the discovery of #telomerase, an enzyme that synthesizes the ends of chromosomes, protecting them and maintaining the integrity of the genome. buff.ly/3WPbCcz
buff.ly/4jPP3y0

Resveratrol Is a group of compound called polyphenols. They are known to act as antioxidant.

Resveratrol

www.linkedin.com/pulse/resver...

#resveratrol #wikipedia #polyphenols #antoxidants #science #chemistry #organic #molecule #cancer #anticancer #telomerase #chromosome #chromosomes #stroke #heartdisease #heartattack #grape #vine #allergy #obesity #SIRT1 #geneexpression #promoter

#Telomerase #RNA #Structure #Spombe #FissionYeast

S. pombe telomerase RNA: secondary structure and flexible-scaffold function

Karen McMurdie, Allison N. Peeney, Melissa A. Mefford, Peter Baumann, David C. Zappulla

www.biorxiv.org/content/10.1...

Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential - Nature Communications Several multi-cancer GWAS loci within the region encoding telomerase reverse transcriptase (TERT) have been identified. Here, the authors explore the locus within TERT intron 4, link it with a variabl...

For many years, we knew that #telomerase has multiple #splicing isoforms that are differently expressed in #cancer cells. This study now shows the impact of retaining or skipping specific introns on cellular longevity, replicative potential, and germline cancer risk.

www.nature.com/articles/s41...

From novel discovery to anti-aging therapy | Cold Spring Harbor Laboratory Major scientific breakthroughs are often dismissed as “novel” discoveries. This is especially true in fundamental biology. It’s hard to fathom the importance of something if its real-world application...

In light of #WorldCancerDay, we want to highlight Dr. Carol Greider who made a discovery that would change our understanding of aging and cancer. She identified the enzyme telomerase, which plays a critical role in senescence and cancer cell survival.

#CancerResearch #Telomerase #NobelPrize

We are looking for a #Postdoc to join our team to work on a funded project by La Ligue investigating the role of #gut permeability as a cause of #cancer with #age. 🐟🐟🐟
#zebrafish #telomerase #microbiome DEADLINE: 29/Jan/2025
Please help us spread the word! 🙏

#quotes #books #excerpts #citations #cancer #telomeres #telomerase #cells #hayflicklimit #division #mitosis #aging #senescence #molbio #biology

The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma Most cancers re-activate telomerase to maintain telomere length and thus acquire immortality. Activating telomerase promoter mutations are found in ma…

Our last study👇- loss of #telomerase drives #cancer #regression through dual mechanisms! In #zebrafish #melanoma, tumors collapse via tumor-autonomous pathways (apoptosis, cell-cycle arrest, differentiation) and nontumor-autonomous #immune rejection.
Go Fish 🐟!
www.sciencedirect.com/science/arti...

Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...

“In this Review, we discuss #telomere protection, maintenance and damage. We highlight the differences between #human and #mouse telomere biology that may contribute to discrepancies between human #diseases and mouse models.” #telomerase #aging
www.nature.com/articles/s41...

It was a great pleasure to be invited to talk at the #SPIM - Skin Physiology International Meeting in #Vichy about our model of #telomerase 🧬 mutant premature #aging in #zebrafish🐟. It was great to highlight the potential of this vertebrate model to pharmaceutical💊and clinical scientists🩺.
Go Fish!

Interesting facts #3
#LobsterFacts #BiologicalImmortality #MarineBiology #NatureScience
#WildlifeConservation #OceanLife #SustainableSeafood #Telomerase
#AquaticLife #SeaCreatures #UnderwaterWorld #MarineEcosystem
#Biodiversity #ScienceFacts #AnimalBehavior #LobsterLovers

Family's rare telomere mutation reveals new insights into telomere flexibility and disease Researchers discovered a rare telomere mutation (TTAGGT) in a family, revealing that human telomeres can tolerate non-canonical sequences, impacting telomere maintenance and disease.

Family's rare telomere mutation reveals new insights into telomere flexibility and disease 🧬🔬📖 www.news-medical.net/news/2024060... #Genetics #Telomeres #Mutation #Telomerase #Science #Research #DNA #Health #Genome #Biology @natureportfolio.bsky.social