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Speakers include: @nozomi-ando.bsky.social @hkws.bsky.social, @pilarcossio.bsky.social, @cjjackson.bsky.social, @karsonchrispens.bsky.social, @alisiafadini.bsky.social, @thompson-lab.bsky.social, Joey Davis, Alex Bronstein, Rohith Krishna, Matthew McPartlon, Frederic Poitevin

Hosted in partnership with the DiffUSE Project! 🎉👇

Congrats to DiffUSE lead Stephanie Wankowicz @stephanieaw.bsky.social, on winning the inaugural Sheldrick Award! Her work on entropic flexibility and reproducibility in structural biology is core to what we're building. #crystallography #structuralbiology #openscience

aucryst.org/sheldrick-aw...

We observed a tradeoff: weak guidance improves fit to data without wrecking protein geometry. But strong guidance destroys the geometry. Interestingly, models differ a lot in how they handle this despite similar architectures.

Excited to share Sampleworks led by @karsonchrispens.bsky.social with @diffuseproject.bsky.social. It's a modular framework connecting structure predictors to experimental data and guidance methods. Swap predictors or guidance methods. All open and made to be built upon. t.co/fvNHH3gfVu

Why I’m joining Astera to lead Radial The systems that enable how we fund, do, and build upon science have long needed an update.

There's a missing middle in science funding: too unglamorous for journals, too ambitious for VC, too cross-functional for one lab. Radial CEO @beckypferdehirt.bsky.social on why she's building something new, starting with DiffUSE: beckypferdehirt.substack.com/p/why-im-joining-astera-to-lead-radial

DiffUSE is expanding. We're rethinking how dynamic structural data is collected, modeled, shared, and interpreted across the entire pipeline. Read more from @stephanieaw.bsky.social diffuse.science/posts/expand...

Announcing Radial, Astera’s new life sciences division Today, Astera Institute is launching Radial, a division which reimagines how life sciences research happens at a systems level.

Read more from @seemaychou.bsky.social here: open.substack.com/pub/asterain...

New nonprofit launches with at least $500 million to modernize scientific process for AI era A new nonprofit called Radial is launching with at least $500 million to modernize the scientific process for the AI era.

Radial is live! A new organization at @asterainstitute.bsky.social bringing together structural biologists, engineers, and ML scientists to redesign how we do science. @statnews.com has the story: www.statnews.com/2026/03/11/r...

MD simulations show that diffuse scattering patterns shift depending on whether ligand or a buffer molecule occupies the binding pocket. The differences are quantitatively significant, a promising sign that experiments could detect these changes. Read more: diffuse.science/post/shake-i...

Tomorrow (2/27) 3 pm ET, DiffUSE Project Scientist Steve Meisburger presents "Diffuse Scattering Wars (Episode IV): A New Hope for Structural Biology"

Learn how diffuse scattering could reveal what AI structure predictors are missing. Join here: www.chess.cornell.edu/science/ches...

Apply here! diffuse.science/careers/

The Diffuse Project is looking for an amazing Project Manager to help us achieve our goal of unlocking protein dynamics! Are you a scientist who naturally loves organization, coordination, problem solving and working with a diverse team of scientists & engineers?

Diffuse Project Interest Form Interested in the Diffuse Project? Please provide your information to help us shape community engagement and potentially direct you to the right project member.

Want to get involved, share your ideas, or just stay in the loop with email updates? Let us know here: forms.gle/37pK2smABwbg...

Happy @diffuseproject.bsky.social launch day! Check out our latest effort. We're grappling with how to better understand protein dynamics and capture/share the information that would best allow the community to make use of that data. Take a look!

The Diffuse Project The Diffuse Project

What’s the next PDB? Maybe it’s …the PDB.

We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇

www.diffuse.science

We’re hiring! Check out our postings for a Machine Learning Scientist, a Machine Learning Infrastructure Engineer, and a Software Engineer:
diffuse.science/careers/

Learn more about how we’re building new infrastructure for structural biology's dynamic future: diffuse.science

From systems operators to systems architects Going up a level from data generation to think about the data systems we design and embed

Announcing the Diffuse Project! We're unlocking protein dynamics through diffuse X-ray scattering - the overlooked signal that could revolutionize how we understand protein motion. seemay.substack.com/p/from-syste...