Register to The PALS Summer School in TranscriptOMICS
👉 Before April 15
And Learn how to perform:
Single-cell Multiome data analysis and integration — workflow management and reproducibility
from Daniel Mouzo @qmul.bsky.social
@scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪
To learn about
➡️ Dynamics of immunological tissue architecture in the human gut ⬅️
by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se
@kawresearch.bsky.social @remeseiro-lab.bsky.social
REGISTER NOW!
www.trippus.net/summerschool...
Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪
To learn about
➡️ Transposable elements and the human brain ⬅️
by ⭐ professor Vivien Horvath⭐ from @umeauniversitet.bsky.social
@kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social
REGISTER NOW!
www.trippus.net/summerschool...
How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔
Most models assume the random forces driving locus motion are independent in space
New preprint by
@janniharju.bsky.social: this assumption fails in living cells 🧵
www.biorxiv.org/content/10.6...
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
Congratulations @ivaskalab.bsky.social team for this study on the role of vibration in vocal cord cancer! Was a fun collaboration 🎤🎤
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
I’d say both would be welcome by many :)
Led by Alessia Maria Pignataro & Cornelia Schwarz, with Emilia Wiechec, Alessandro Cordiale, Shyama Sasikumar, Alexander Jenssen, Taka Ariyaberg, Lalit Khare, Ehsanul Hoque Apu, Karin Roberg, Sajjad Naeimipour, Gabriela Carballo, Marcin Szczot, Daniel Aili & Marco Rasponi - @liu.se & @polimi
Overall, this is a versatile model for interrogating solid tumor progression, therapeutic response, drug transport across extracellular and vascular barriers, and neural regulation of cancer growth and pain.
These same eECMs were used to generate injectable, hESC-derived three-dimensional human trigeminal ganglia containing diverse neuronal and glial populations,
We introduce the on-chip use of fully defined engineered extracellular matrices (eECMs) based on hyaluronic acid and PEG, crosslinked via click chemistry and independently tunable in stiffness, composition, and degradability.
Direct contact between axonal terminals and the tumor enables interrogation of how sensory innervation influences tumor growth and invasion. The dedicated neural compartment further allows imaging-based analysis of neuronal activity during tumor progression and treatment
The direct physical interface between the 3D tumor and vasculature permits analysis of collective invasion, metastatic dissemination, and systemic delivery of therapeutics, including drugs and immune-based therapies.
In brief:
- we recapitulate three fundamental and broadly conserved three-dimensional interfaces governing solid tumor behavior: the tumor–extracellular matrix, tumor–vasculature, and tumor–innervation interfaces.
Fresh pre-print: our all-human, innervated & vascularized oral cancer-on-chip, all done with fully defined extracellular matrices with controlled enrichment and degradability! 🔥
www.biorxiv.org/content/10.6...
#SpatialTranscriptomics
Visium
+ scRNAseq
Oral Squamous Cell Carcinoma
vs paired Oral Leukoplakia vs normal tissues
Inhibin A+ monocyte enriched in premalignant OLK lesions
1⃣Mesenchymal CAF 2⃣APOE+NRG1+ Mφ 3⃣TNFRSF4+ Treg ⬆️with tumor progression
#CellDiscov 2023
www.nature.com/articles/s41...
In press: our brief review about the efforts to emulate the dental pulp using organ-on-a-chip approaches
”Dental Pulp-On-Chip” Microfluidic Devices for Emulating Human Dental Pulp Tissue Physiology and Pathology - Journal of Endodontics www.jendodon.com/article/S009...
”Aka: we shrank the yeast ” should have been an integral component of the title!
Super - exciting work!
A majestic tour-de-force by @szczotml.bsky.social lab at @liu.se - beautiful combination of function & transcriptional identity to understand how pain is encoded across the body 👇🏼👇🏼
…and delivers tons of exciting stuff!
Mapping genome-wide binding AND protein partners of virtually any gene regulator , simultaneously, without transgenesis? YES 👇🏼👇🏼👇🏼👇🏼
Look at what @annanordin.bsky.social & @claudiocantu81.bsky.social cooked!!
Please please read this.
Is it only me that finds them also incredibly awful?
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
Tomorrow Wednesday 29th at 11am, lesson #3 of @neilshubin.bsky.social guest Professor @college-de-france.fr on ‘The evolutionary origin of bones and teeth’. The second lesson is available @ www.youtube.com/watch?v=0B6y... . No registration, Free access, dentures accepted.
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence
www.nature.com/articles/s43...
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
