Yes, Virginia. And yes, 76ers!

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects ...

Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...

Second, a new preprint examining how binding of cargo adaptors is integrated with direct association of the motor complex with membranes is available on bioRxiv. We identify the kinase NEK10 as a Kinesin-1/KLC2-selective negative regulator of lysosome transport www.biorxiv.org/content/10.6...

Check out our new release on BioRxiv
co-lead by @pm-mueller.bsky.social

👉 rb.gy/lnrizk

special🙏 to
Severine Kunz #MDC
@leventallab.bsky.social
@andimicroscopy.bsky.social
@ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM

Are the days of discovering new cellular structures over?? /1

Mythos!?!

@sergemostowylab.bsky.social

"When they go low, we go high"

Congrats!

I vote for these two!

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.
bit.ly/4moYLJH

Bruh!

Albini Sessions (Benefit for Letters Charity), by Fugazi 12 track album

Fugazi released last month the scrapped 1992 recording sessions with Albini to raise funds for Letters to Santa - a Chicago-based charity that the late Albini started in the 90s.

Good cause to support by purchasing on bandcamp - and the tunes are 🔥🔥🔥

fugazi.bandcamp.com/album/albini...

The gamma-Tubulin Ring Complex promotes mitotic spindle integrity and acts as a microtubule minus-end cap during mitosis www.biorxiv.org/content/10.64898/2026.04...

A book chapter we wrote awhile ago:

Peering into the Septin Cytoskeleton – New Insights Unlocked by Microscopy Advances

Andrew W. Schaefer and Elias T. Spiliotis

onlinelibrary.wiley.com/doi/abs/10.1...

Out now in the new Royal Microscopy Society book

"Live Biological Imaging Across Scales"

#ThingsWeDoWhenThePrezIsInTown
Pinkish @ Rivanna Area Queer Center

Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state Nature Structural & Molecular Biology, Published online: 08 April 2026; doi:10.1038/s41594-026-01787-7Zehr et al. revealed the 2.7-Å cryo-electron microscopy reconstruction of human microtubules in situ in the axon of induced pluripotent stem cell (iPS cell)-derived neurons. It shows an expanded microtubule lattice yet bound to GDP, in contrast to the compacted lattice observed at the iPS cell stage.

New online: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state

New preprint out! 🚀
biorxiv.org/content/10.6...

We mapped how septins organise infection in the rice blast fungus—and found they are far more dynamic than previously thought.

Thread 👇

#FungalPathogenesis #CellBiology #septins

Septins don’t just form structures - they reorganise over time.

Their interaction networks are dynamically rewired across infection stages, linking septins to diverse cellular processes not previously connected to septin function.

Truth!

Yes!

Add 10 more spectrin paralogs and you have septins!

Apparently they started at NYU as a Strokes cover band, I saw in an interview. Didnt know that when I posted. But they also sound a lot like Parquet Courts, which is how I discovered them.

SNOWMEN - Make Time/Waste Time (Official Video) YouTube video by SNOWMEN

These guys are an inch away from becoming the new... Strokes. From NYC, former NYUers. My favorite new band as of today.

www.youtube.com/watch?v=oV3i...

Happy and honored to be part of JCB's newest editorial board additions. Looking forward to new and exciting cell biology!

Epic crap! My uncle drove this Citroën DS in Greece in the late 1970s, early 1980s.

Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture YouTube video by Nobel Prize

Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...

David Botstein, Gene-Mapping Pioneer, Dies at 83

David Botstein was one of the giants of genetics and genomics, and my mentor, colleague and friend for more than 40 years. I’m sad that he is gone, but his larger-than-life persona comes through here. www.nytimes.com/2026/03/20/s...

a man is holding a sign that says price on it ALT: a man is holding a sign that says price on it

Seems like these addgene plasmids going up in price every year... $89 now.

The revolution will not be televized... but the dissection is.
Great set up to watch the world cup while tissue culturing.

a baseball player with a p on his helmet ALT: a baseball player with a p on his helmet

#NotElite

Funding level grandfathering based on initial 1 or 2 R01s posession is a fundamental flaw of MIRA. People who doing well & would have had two R01s are forever locked with one R01 level of funding, and those with higher levels have no incentive. Modest budget adjustments at renewal dont remedy this!