🔗 link to #OpenAccess paper: doi.org/10.1093/post...

#rstats #regression #nonlinear #rms #openaccess #statistics

🙏 Huge thank you to @georgek.medsky.social (co-developer of the package), Sarah Elliot , and @ewenharrison.bsky.social for their guidance and support.

🔗 Additional resources provided:
- Regression modelling playground web application: geokour.shinyapps.io/Non_linear_m...
- R scripts with case study workflow as supplementary materials and on GitHub: github.com/rmsMD/Non-li...
- Further vignettes on the rmsMD website: rmsmd.github.io/rmsMD

❓ Why this matters:
- Default regression models assume that relationships form straight lines
- Linearity assumption is often inappropriate in healthcare data
- We discuss pitfalls, and provide with educational tools
- We work through a simple case study and provide all code

🔥 Launch of rmsMD R package 🔥
📈 Streamlined functions for summarising and visualising non-linear regression models
🔑 Core focus is simplicity, and output of publication ready tables and plots for medical journals

🔗http://rmsmd.github.io/rmsMD

🚨📢 Incredibly proud to share our new paper and R package on non-linear regression modelling for medical professionals; making it simple!

🔗 Open access paper: doi.org/10.1093/post...
#rstats #nonlinear #biostatistics

More details 🧵👇👇👇

Machine Perfusion in Deceased Donor Kidney Transplantation: Editorial Summary of a Cochrane Review by @samjtingle.bsky.social and Colin Hugh Wilson

bit.ly/AJKD25Tingle... (FREE)

Massive thank you to @georgek.medsky.social @ukri.org @kidneyresearchuk.org @wellcometrust.bsky.social @nihr.bsky.social

Frontiers Publishing Partnerships | Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion Normothermic machine perfusion (NMP) provides opportunity for viability assessment of donated kidneys. Diminished microvascular perfusion, despite adequate t...

📊 Bonus: We built an open-source R package + web app for CEUS time-intensity analysis!
Check it out here 👉 stingle.shinyapps.io/Time_intensi...

🔗 Read the full #OpenAccess article in Transplant International: doi.org/10.3389/ti.2...

#Transplantation #KidneyResearch #MachinePerfusion

💡 Why it matters:

CEUS could provide real-time, objective assessment during NMP—supporting viability decisions at organ assessment and reconditioning centres (ARCs)

❗️But validation in transplanted kidneys is still needed

🔑 Key findings from porcine and human kidney models:
1️⃣ Microvascular perfusion at 2h correlated with markers of injury
2️⃣ Total renal blood flow did not
3️⃣ CEUS is safe, non-toxic, & potentially bedside-friendly

❓Can we predict kidney viability before transplantation—non-invasively, in real time?

Our latest study explores contrast-enhanced ultrasound (CEUS) during normothermic machine perfusion (NMP) to assess microvascular perfusion, a key factor in ischaemia-reperfusion injury🧵👇

Thank you for the invitation!

Introducing the new "NOPE" algorithm

This algorithm will tell you "no" all the time. It has been shown to be up to 95% accurate in situations with a prevalence of 5% and *what is even better* even *more accurate* in rarer diseases

Great start!

Started an HPB surgery starter pack! go.bsky.app/7Z2kqK6 Let’s add to the list! Residents, fellows, attendings, professors 😊

#transplant #transplantation #DCD

Donor Time to Death and Kidney Transplant Outcomes This cohort study assesses whether prolonged donor time to death after withdrawal of life-sustaining-treatment is associated with kidney transplant outcomes.

Full #OpenAccess free article:
jamanetwork.com/journals/jam...

A massive thank you to the full team, supporting institutions, funders, donors and their families 🙏

@georgek-dr.bsky.social @oudt-nhsbt.bsky.social

🔑 Time to death was not associated with recipient eGFR, DGF or graft survival

🔑 Compared to a 1 hour stand down policy, the 3 hour minimum wait ⬆️ #DCD transplant by 14%

🔑 Simple and safe change for organ donation organisations globally

Amazing to see this published in JAMA network open after so much work from a great team 🎉

❓ Does #DCD donor time to death impact kidney transplant outcomes?

🔑 We assessed this in a UK cohort, where the minimum stand-down time is 3 hours!

⬇️ Full #OpenAccess paper