Napíšu Vám do soukromé zprávy, až budu mít prostor

Ahoj Marki, pravda, jsem tady málo. Teď jsem málo i na Twitteru, protože jsem si dal půst 🙂 ale pokud budu umět, tak odpovím.

In a patient suspected to have PA, with high aldosterone, could discrepancy between direct renin measurement (increased) and PRA (lower norm) be caused by a beta-blocker? Re RAS inhibition, no direct renin inhibitor, only ARB in the medication. Thank you! #askrenal

🤓😁

NEJM and public health group are launching rival to CDC’s MMWR publication Two institutions are coming together to create an alternative to the CDC’s vaunted Morbidity and Mortality Weekly Report

Cool development

@nejm.org Evidence will publish a section in association with @cidrap.bsky.social on public health and vaccine issues usually covered by the now-dead MMWR

www.statnews.com/2025/10/21/c...

#publicHealth #MedSky

from my small experience, the young patients with normal GFR were already borderline hypotensive on ACEi plus gliflozin

I have also started so far in two patients with G1A3. No reimbursment in that case, however.

Current European Alport guidelines suggest SGLT2i for CKD2 + proteinuria. I personally use if proteinuria not controlled with ACE/ARB no matter GFR. pubmed.ncbi.nlm.nih.gov/39673454/

Despite new retractions, suspect organ transplant papers remain in the literature Six years after researchers called for the retraction of more than 400 papers about organ transplantation amid suspicion the organs used in the studies came from executed Chinese prisoners, journal…

Data from executed Chinese prisoners and organs transplanted remain published

retractionwatch.com/2025/10/24/d...

#TransplantEthics

Do you guys use flozins in patients with Alport syndrome with proteinuria but still normal GFR?

Hello all, in the summary text, GLP1RA are agonists not antagonists.

In patients with antiHBc total positivity with negative DNA, do you use rituximab (eg AAV) with HBV prophylaxis as a safe alternative? Thank you #askrenal

And it’s live

Iptacopan in C3GN makes it to @thelancet.com

www.thelancet.com/journals/lan...

#NephSky

Have you ever converted a patient after kidney transplantation from tacrolimus to belatacept to improve progressing neuropathy? Have you noticed any beneficial effect? Thank you! #askrenal

Correct. Clinical engineering departments at hospitals/health systems can, theoretically, calibrate devices for you. They typically do this either with a mercury tower or with another device that was recently calibrated. We keep a mercury tower on hand to do this for our research studies 1/2

Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...

The ASIs have arrived

www.nejm.org/doi/full/10....

Aldosterone synthase inhibitors - first one to finish the phase 3 line

#Lorundrostat #Hypertension

It was a great idea. I have already finished one audiobook🙂 the amount of available time is still the same but it seems to bring more brain relax.

Moving to methods: the section you skip to get to the results #nephjc

Subheader: Like metformin in Stage 4 CKD, this won’t clear quickly...but we added jokes!

just learned this & mind blown 🤯

CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)

BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)

in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC

Final_Version_of_Tarrifs_actualFINALcopy_version7_USETHISONE.docx

What is the diagnosis?

#DiagnoseThis #PathX #Pathology #PathSky

URIVAC® Bacterial lysate prepared using special technology from strains of the most common causes of urological inflammations.

We have something called Urivac here, which seems similar, but I am not aware of specific studies. www.bioveta.eu/en/products/...

I still struggle with finding time to read non-medical texts... good for you! How much time per day/week are you able to get?

#WeekendRead from #EditorsChoice archives

Correlates of Nocturnal Hypertension

academic.oup.com/ajh/article/...

#OpenAccess and #Free

Hydroxychloroquine for all patients with lupus nephritis? Yes 🆚 No

Spoiler: 🤝 😎 #NephroContinue

🔗 Yes: academic.oup.com/ndt/article/...
🔗 No: academic.oup.com/ndt/article/...

Global health equity: I nominate @thecurbsiders.bsky.social for creating an entire internal medicine curriculum that can be accessed for free around the world. Incredible reach and impact

Please, what is hemofiltration small molecules clearance compared with HD? Is it comparable or much lower? Intermittent hemofiltrations are sometimes used here primarily for ultrafiltration. Thanks!

Any good reference on intermittent hemofiltration small molecules clearance (compared with IHD)? Thank you! #askrenal