#Dengue virus slips infection-boosting RNAs into mosquito saliva by hitching a ride in EVs, a study finds. The viral RNA hooks onto a mosquito protein, AeSyntenin, to get packaged and released.
#MicroSky #Virology

✍️ @julienpompon.bsky.social & coll.
@ird-fr.bsky.social
📖 shorturl.at/lxUyw

Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses Medkour et al. demonstrate that lipids of the sphingomyelin class in mosquito saliva facilitate the transmission of multiple flaviviruses. These salivary sphingomyelins reconfigure lipid homeostasis i...

Our latest study in #Cell_Metabolism discovers that #lipids in #mosquito #saliva enhance transmission for multiple #flaviviruses. further physiologic and mechanistic insights available. such findings could apply to all #arthropod-borne #transmission. 🦟 🧪

www.cell.com/cell-metabol...

Great job from #marquez lab. It neatly provides a mechanism for our previous observation that #dengue infected #mosquitoes have reduced efficiency in probing to find blood

www.pnas.org/doi/10.1073/...

Zika and chikungunya viruses decrease salivation in Aedes aegypti mosquitoes Aedes mosquitoes transmit viruses of global health concern through blood feeding. While biting, mosquitoes inject viruses but also saliva factors that modulate feeding and potentially viral transmission. However, studying this interplay is limited by our ability to quantify saliva release. Here, we developed a transgenic Aedes aegypti line that secretes fluorescent markers in saliva, enabling visualization of probing sites on human skin explants and quantification of salivation. Saliva secretion remained robust under diverse physiological conditions but was significantly reduced upon Zika or chikungunya virus infection. Nevertheless, virus release did not correlate with levels of saliva factors, suggesting decreased salivation does not lower chances of viral transmission. Our results bring perspective to the previously described increase in probing behavior in infected mosquitoes, indicating it may be caused by lower release of saliva factors. Thus, the negative impact of infection on salivation may have been selected to facilitate virus transmission.

Zika and chikungunya viruses decrease salivation in Aedes aegypti mosquitoes bioRxivpreprint

Dengue and chikungunya risk becoming endemic in Europe as mosquitoes head north Climate change is driving outbreaks of tropical diseases across the continent.

🦟" #Dengue and #chikungunya risk becoming endemic in #Europe as mosquitoes head north. #ClimateChange is driving #outbreaks of tropical diseases across the continent." via @politico.eu
www.politico.eu/article/deng...

Effectiveness of integrated vector management on the incidence of dengue in urban Malaysia: a cluster-randomised controlled trial - PubMed For the Malay translation of the abstract see Supplementary Materials section.

A field trial did not find a clear effect of integrated vector management.
Not much data to support the impact of vector control

pubmed.ncbi.nlm.nih.gov/40373783/

#FLAVIVACCINE's coordinator Julien Pompon's interview YouTube video by FLAVIVACCINE EU

🌍 One Year of Progress for #FLAVIVACCINE!

Our project coordinator @julienpompon.bsky.social of @ird-fr.bsky.social reflects on the achievements of the first year of the FLAVIVACCINE project.

FLAVIVACCINE's mission is to develop a single vaccine targeting multiple flaviviruses.
youtu.be/u9V84vIwePM

Impact of climate and Aedes albopictus establishment on dengue and chikungunya outbreaks in Europe: a time-to-event analysis - PubMed European Union's Horizon Europe.

Increased dengue and chikungunya cases are due to climate change in the EU. Prediction of five fold increase by 2060 with climate change

pubmed.ncbi.nlm.nih.gov/40381632/

Engineered antibody-mediated broad-spectrum suppression of human arboviruses in the Aedes aegypti vector - Communications Biology Overexpression of small antibodies in mosquito midguts inhibits infection by dengue, Zika, chikungunya, and Mayaro viruses. Co-expressing small antibodies with Dcr2 further enhances arbovirus transmis...

Overexpression of small antibodies in mosquito midguts inhibits infection by dengue, Zika, chikungunya, and Mayaro viruses. Co-expressing small antibodies with Dcr2 further enhances arbovirus transmission blockade in mosquitoes.

www.nature.com/articles/s42...

Super psyched to have leading investigator @thehornerlab.bsky.social presenting her team's work THURSDAY 15th May on Zoom.
#flavivirus #virus-host-interactions #innate_immunity #DENV #ZIKV
All are very welcome and please re-post to get the word out. Email organisers for Zoom link. See you there!

Oropouche is spread by midges, not mosquitoes In a new study, Yale researchers conclude that Oropouche fever is spread chiefly by biting insects called midges, while mosquitoes are unlikely to play much of

🪰🦟" #Oropouche is spread by #midges, not #mosquitoes" @yalesph.bsky.social @colincarlson.bsky.social
ysph.yale.edu/news-article...

Frontiers | Characterization of size distribution and markers for mosquito extracellular vesicles

Our latest article on mosquito EV characterization led by Felix Rey Cadilhac and Florian Rachenne is published. It provides a multilevel description of mosquito EVs and markers, all required for documented study. 🧪
www.frontiersin.org/journals/cel...

Frontiers | Characterization of size distribution and markers for mosquito extracellular vesicles

Our latest article on mosquito EV characterization led by Felix Rey Cadilhac and Florian Rachenne is published. It provides a multilevel description of mosquito EVs and markers, all required for documented study. 🧪
www.frontiersin.org/journals/cel...

🩺 Today is #WorldHealthDay! How does research improve #HealthforAll?

Our project coordinator, @julienpompon.bsky.social of @ird-fr.bsky.social gives us an important insight about the contribution of #FLAVIVACCINE to the research of flavivirus-transmitted diseases.

🔗 www.icons.it/news/for-wor...

🔬 Join us for the next session in our seminar series about flaviviruses. We are thrilled to host Dr. @julienpompon.bsky.social

📅 Date: April 10th
🕒 Time: 3:00 PM (Online)

🔗 Register now to secure your spot! forms.office.com/e/itCWqHubWV

#Flaviviruses #EmergentDisease #Pathogens

April 10th at 15h CET, I will present our paper "Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response", driven by Idalba Serrato, during the LWNVIVAT seminar series.
here register: forms.office.com/e/itCWqHubWV

Interested in a #job as a tech in #IVPC lab, Lyon, France? Field work, molecular biology, pathogen detection, entomology in a young, inclusive, sustainable & dynamic environment! Please RT!!
jobs.inrae.fr/concours/con... @inrae-france.bsky.social

Japanese encephalitis virus detected in Brisbane for the first time Queenslanders are being warned against getting bitten by mosquitoes after the Japanese encephalitis virus was found in Brisbane.

#Australia🇦🇺: #JapaneseEncephalitis #virus detected in #Brisbane for the first time, triggering health warnings 🦟
www.abc.net.au/news/2025-03...

Funded postdoctoral position in the Lecuit lab at Institut Pasteur - Research

We are hiring!
Interested in infection biology, immunology, microbiology?
Funded postdoctoral position in our lab at Institut Pasteur research.pasteur.fr/en/team/biol...
@inserm.fr

Contact us at postdoc.biu@pasteur.fr
research.pasteur.fr/en/job/funde...

Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 variants The mosquito Aedes aegypti is the primary vector for dengue virus (DENV), which infects millions of people annually. Variability in DENV susceptibility among wild Ae. aegypti populations is governed b...

Happy to share our work exploring the genetic basis of dengue susceptibility in Aedes aegypti and revealing the antiviral role of a cytochrome P450. www.biorxiv.org/content/10.1...
It had been a long and wild ride that started back when I was a postdoc within @lambrechtslab.bsky.social ! A thread ⬇️

ALLEA Statement on Threats to Academic Freedom and International Research Collaboration in the United States

The European federation of Academies of Sciences has posted a statement of concern about the developments in the US. They now have added the option to endorse this statement as an organisation. Would be great if this could go viral. allea.org/portfolio-it...

Aedes albopictus is rapidly invading its climatic niche in France: wider implications for biting nuisance and arbovirus control in Western Europe www.biorxiv.org/content/10.1101/2025.02....

FLAVIVACCINE on LinkedIn: #flavivaccine Have you already signed up for our newsletter? 📥 https://lnkd.in/dB3AMiyX Flavivirus infections pose significant challenges to public health. Our project…

An ambitious @HORIZON funded project to deliver a pan-flavivvirus vaccine, led by @ird-fr.bsky.social with a consortium including @cea, @university_of_utretch, @csic.es , @ucirvine.bsky.social , @WRAIR, @icons, and @conserbioScienc
www.linkedin.com/posts/flaviv...

The role of vector population variation and climate in Zika virus transmission patterns in Africa: a modelling study Zika virus (ZIKV) outbreaks have raised major global health concerns recently, yet reported outbreaks are rare in Africa, where ZIKV was first discove…

Why are #ZIKV outbreaks rare in Africa, where it was first discovered? New research reveals #mosquito genetics play a more significant role than climate in determining ZIKV transmission patterns. Future projections suggest rising outbreak risks in urban Africa. www.sciencedirect.com/science/arti...

Great job Idalba Serrato Pomar

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Bite-initiated skin infection represents a critical and conserved s...

preprint advancing #flavivirus transmission understanding: 1. Flavivirus-infected #mosquito saliva always contain sfRNA inside lipide #vesicles. 2. Salivary sfRNA increases transmission by inhibiting MDA5-mediated interferon signalling.

www.biorxiv.org/content/10.1...

Infectious diseases in 2025: a year for courage and conviction “The COVID-19 crisis may have passed, but a harsh lesson remains: the world is woefully unprepared for the next pandemic”, said António Guterres, UN Secretary-General, on the International Day of Epidemic Preparedness, Dec 24, 2024. His remarks resonated with those of WHO Director-General Tedros Adhanom Ghebreyesus when asked whether the world is better prepared for the next pandemic. He noted that while some painful lessons have been learnt, many of the same weaknesses and vulnerabilities that allowed COVID-19 to gain a foothold 5 years ago still exist.

www.thelancet.com/journals/lan...

New study on dengue importation dynamics in Africa combining passenger flight, suitability, and seasonal transmission dynamics.

Led by Jenicca Poongavanan and Houriiyah Tegally.

www.sciencedirect.com/science/arti...

See this super cool seminar by Tineke Contort (@pasteur.fr Cambodia) that I am helping to co-chair with Tim Morrison (Colorado) THIS THURSDAY by zoom. All welcome!