Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Huang et al. show that excessive vigorous exercise causes cognitive impairment. During this process, muscle lactate accumulation facilitates the secretion of otMDVs through ATF5 lactylation. PAF and m...

Interesting new #Cell_Metabolism paper: Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender. #Myoblue tinyurl.com/m3w26zta

Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses Medkour et al. demonstrate that lipids of the sphingomyelin class in mosquito saliva facilitate the transmission of multiple flaviviruses. These salivary sphingomyelins reconfigure lipid homeostasis i...

Our latest study in #Cell_Metabolism discovers that #lipids in #mosquito #saliva enhance transmission for multiple #flaviviruses. further physiologic and mechanistic insights available. such findings could apply to all #arthropod-borne #transmission. 🦟 🧪

www.cell.com/cell-metabol...

Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline Song et al. identify an alternative pathway for maintaining NAD+ homeostasis through circulating NaR production and consumption by the liver-kidney axis, and boosting this pathway ameliorates aging-as...

Interesting another new #Cell_Metabolism paper: Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline. tinyurl.com/5b9p6h9v

Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk Van der Stede et al. identified a role for mononuclear cells in the skeletal muscle microenvironment to steer the response to exercise. Mast cells locally secrete histamine during exercise, triggering...

New #Cell_Metabolism paper: Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk. #MyoBlue tinyurl.com/ymc5ha3w

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining Liu et al. show that overtraining promotes liver fibrosis. During this process, muscle lactate accumulation facilitates the sorting of FBXO2 into small extracellular vesicles (SEVs) through SORBS3 lac...

New #Cell_Metabolism paper: Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining. #MyoBlue tinyurl.com/muet45td

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis Dietary fat drives the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), particularly through circulating cholesterol and triglyceride-r…

Out this week in #Cell_Metabolism: The work with the Metallo lab @salkinstitute.bsky.social showing that trans-fat promotes hepatic serine palmitoyltransferase flux (SPT), VLDL secretion, and #atherosclerosis. SPT inhibition reduces VLDL and atherosclerosis. www.sciencedirect.com/science/arti...