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Posts by Nezha Benabdallah

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Crick Crash Course: Embryo development

I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍

1 day ago 69 25 0 1

Here too🙋‍♀️

3 days ago 1 0 0 0
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What does it take to truly understand #cancer in all of its complexity?

Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️

www.cell.com/cell/fulltex...

5 days ago 68 33 7 0

there goes the central dogma, i guess. is nothing sacred anymore?

4 days ago 51 9 3 0
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Mitotic reactivation and transcriptional bursting govern transcriptional noise in the early Drosophila embryo Summary: Transcriptional variability in developing Drosophila embryos is time dependent, peaking after mitosis due to nucleus-to-nucleus differences in post-mitotic reactivation timings, and declining...

🧬📖 En page de couverture de Development : publication de Louise Maillard @lmaillard.bsky.social (équipe Mounia Lagha @laghalab.bsky.social) et ses collaborateurs !
🔬✨ Un très beau travail d’équipe 👏
@dev-journal.bsky.social @biologists.bsky.social
journals.biologists.com/dev/article/...

6 days ago 13 5 0 0

Yay! Huge congrats Tom!!

6 days ago 1 0 0 0

Congratulations Ernest, Aude and team!! Beautiful work 🤩

2 weeks ago 2 0 1 0

How diverse is bacterial immunity ?

We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...

Explore them here defensefinder.mdmlab.fr/wiki/refseq_...

2 weeks ago 227 112 10 3
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We are recruiting!

We are searching for an exceptional postdoctoral fellow to lead the single-cell phenoscaping efforts of the REWIRE-CAN Cancer Grand Challenge @cancergrand.bsky.social

For more information and to apply please visit: www.ucl.ac.uk/work-at-ucl/...

3 weeks ago 8 8 0 0
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Join IGH as Group Leader - IGH The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

1 month ago 46 60 0 1

Amazing news!! Congratulations Agnese!

1 month ago 1 0 1 0
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🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders!
Announcement here:
www.i2bc.paris-saclay.fr/join-i2bc/te...
Open to early career scientist from anywhere or mid-career already in France. Please RB!

1 month ago 11 16 1 0
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We are offering 5 Postdoc Positions within the Max Planck Postdoc Program!

Take advantage and apply by April 13, 2026 to the positions in the labs of @ralfhadams.bsky.social, @ruibenedito.bsky.social and @katemiro.bsky.social.

Link to our website:
www.mpi-muenster.mpg.de/max-planck-p...

1 month ago 6 6 1 1
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*Recruiting new group leaders*

The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.

1 month ago 13 14 2 0
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1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

2 months ago 41 20 1 1
Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by:
1. Meticulously annotating cell clusters
2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements
3. Using deep learning to identify regulatory syntax
4. Resolving context-specific TF activity

Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by: 1. Meticulously annotating cell clusters 2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements 3. Using deep learning to identify regulatory syntax 4. Resolving context-specific TF activity

Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...

2 months ago 32 15 2 0
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Opinion | I’m the Prime Minister of Spain. This Is Why the West Needs Migrants.

'The regularization effort underway in Spain actually began as a citizen-led initiative endorsed by more than 900 nongovernmental organizations, including the Catholic Church, and it has the support of business associations and trade unions alike.'

www.nytimes.com/2026/02/04/o...

2 months ago 6 6 0 0
EZS European Zebrafish Society The European Zebrafish Society was formed as a successor of "EuFishBioMed e.V." to foster zebrafish research, providing a platform for researchers and a framewokr for grant funding for young researche...

Congratulations to @ezsociety.bsky.social Christiane Nüsslein-Volhard Award winner Liz Patton for her pioneering work with zebrafish models in melanoma research, outstanding scientific excellence, unwavering dedication to community service & shaping of learned societies 👉https://edin.ac/4r1an7d

2 months ago 7 2 0 0
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RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ https://genesdev.cshlp.org/content/40/3-4/185.full

Edinburgh University
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

2 months ago 6 3 0 0

This is for you – and a great opportunity – if you are establishing a group in Croatia, Czechia, Estonia, Hungary, Lithuania, Luxembourg, Poland, Portugal and Türkiye...

2 months ago 6 8 0 0
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DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

www.nature.com/articles/s41...

happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis

2 months ago 22 7 1 0
Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

2 months ago 14 18 0 0
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Today in @natgenet.nature.com, we report a saturation genome editing study that systematically dissects the degron of β-Catenin, which contains 5 of the 25 most frequently mutated regions of the human cancer genome, and >70 recurrent missense mutations.

rdcu.be/e1Tvk

2 months ago 16 5 3 0

Congratulations Pradeep!

2 months ago 1 0 1 0
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Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...

2 months ago 36 14 7 1
An example of a voter suppression ad on Facebook. This ad was part of a Russian election interference campaign.

An example of a voter suppression ad on Facebook. This ad was part of a Russian election interference campaign.

Exposure to voter suppression ads on Facebook—which targeted non-White residents of battleground states—was associated with a 1.9% decrease in voter turnout in the 2016 election, representing approximately 4.7 million fewer votes nationwide. In PNAS: https://ow.ly/HJGf50Y7FPG

2 months ago 10 7 0 1
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📣 I'm excited to share our latest preprint!

We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫

Read about Array-CNCC here:
www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social

2 months ago 49 14 2 1
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity Synovial sarcoma is driven by the SS18-SSX fusion oncoprotein, which has been assumed to promote tumorigenesis through its incorporation into the SWI/SNF chromatin remodeling complexes. Accordingly, therapeutic efforts have focused on targeting SS18-SSX containing SWI/SNF assemblies, yet these approaches have produced limited clinical benefit. Here, we demonstrate that SS18-SSX sustains oncogenic transcription independent of SWI/SNF activity. Despite efficient degradation and dismantling of SWI/SNF complexes, fusion occupancy at target loci and associated gene expression programs remain largely intact. Instead, we identify the acetyltransferase P300 as an essential co-factor supporting SS18-SSX chromatin binding and transcriptional activation. Targeting P300 displaces the fusion from chromatin, suppresses its transcriptional output, compromising synovial sarcoma viability. Notably, dual PROTAC mediated degradation of P300 and SWI/SNF produces strong synergistic effects, broadly disrupting SS18-SSX localization and function. These findings redefine the mechanistic basis of synovial sarcoma and reveal a mechanistically anchored therapeutic strategy for targeting its core oncogenic driver. ### Competing Interest Statement C.R.V. has been a consultant for Flare Therapeutics, Roivant Sciences and C4 Therapeutics; has served on the advisory boards of KSQ Therapeutics, Syros Pharmaceuticals and Treeline Biosciences; has received research funding from Boehringer Ingelheim and Treeline Biosciences; and owns stock in Treeline Biosciences. S.A.A. has been a consultant and/or shareholder for Neomorph, Imago Biosciences, Hyku Therapeutics, C4 Therapeutics, Accent Therapeutics and Nimbus Therapeutics; and has received research support from Janssen and Syndax. N.O.C. is a co-founder, shareholder and management consultant for PhenoTherapeutics Ltd; and a shareholder in Amplia Therapeutics Ltd All other authors declare no financial interests UKRI, EP/X039633/1 Worldwide Cancer Research, https://ror.org/031tfbz57, 21-0271 Science Foundation Ireland, https://ror.org/0271asj38, 18/SIRG/5573

Synovial sarcoma is driven almost exclusively by a single oncofusion – SS18-SSX

For years, the assumptions on disease mechanisms were simple:

➡️ SS18-SSX works by hijacking SWI/SNF chromatin remodeling activity

Our new study shows that assumption was wrong 🧵👇

www.biorxiv.org/content/10.6...

2 months ago 30 12 2 3

I did not know she was on Bluesky, but this whole work was led by @afroditisotiriou.bsky.social, a truly talented scientist that will finish her PhD this year and has not started looking for postdoc positions yet...

2 months ago 0 0 0 0
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity Synovial sarcoma is driven by the SS18-SSX fusion oncoprotein, which has been assumed to promote tumorigenesis through its incorporation into the SWI/SNF chromatin remodeling complexes. Accordingly, therapeutic efforts have focused on targeting SS18-SSX containing SWI/SNF assemblies, yet these approaches have produced limited clinical benefit. Here, we demonstrate that SS18-SSX sustains oncogenic transcription independent of SWI/SNF activity. Despite efficient degradation and dismantling of SWI/SNF complexes, fusion occupancy at target loci and associated gene expression programs remain largely intact. Instead, we identify the acetyltransferase P300 as an essential co-factor supporting SS18-SSX chromatin binding and transcriptional activation. Targeting P300 displaces the fusion from chromatin, suppresses its transcriptional output, compromising synovial sarcoma viability. Notably, dual PROTAC mediated degradation of P300 and SWI/SNF produces strong synergistic effects, broadly disrupting SS18-SSX localization and function. These findings redefine the mechanistic basis of synovial sarcoma and reveal a mechanistically anchored therapeutic strategy for targeting its core oncogenic driver. ### Competing Interest Statement C.R.V. has been a consultant for Flare Therapeutics, Roivant Sciences and C4 Therapeutics; has served on the advisory boards of KSQ Therapeutics, Syros Pharmaceuticals and Treeline Biosciences; has received research funding from Boehringer Ingelheim and Treeline Biosciences; and owns stock in Treeline Biosciences. S.A.A. has been a consultant and/or shareholder for Neomorph, Imago Biosciences, Hyku Therapeutics, C4 Therapeutics, Accent Therapeutics and Nimbus Therapeutics; and has received research support from Janssen and Syndax. N.O.C. is a co-founder, shareholder and management consultant for PhenoTherapeutics Ltd; and a shareholder in Amplia Therapeutics Ltd All other authors declare no financial interests UKRI, EP/X039633/1 Worldwide Cancer Research, https://ror.org/031tfbz57, 21-0271 Science Foundation Ireland, https://ror.org/0271asj38, 18/SIRG/5573

Also very cool co-ordinated back-to-back with a sister preprint from colleagues (and office mate) @gerrybrien.bsky.social reporting the same finding 🤝
www.biorxiv.org/content/10.6...

2 months ago 2 0 0 0