New data on role of CaM kinase II in #myocardium stretch-induced compliance, independent of protein #kinase G, but likely through shared #phosphorylation targets with PKG, implicating #CaMKII as a possible modulator of diastolic function
doi.org/10.14814/phy...
#Cardiac #Physiology

I have multiple positions available to join my lab from this summer: #postdoc, #student and #technician. Adverts to follow but see www.saurinlab.com for further details. #senescence, #mitosis, #cellcycle, #phosphorylation are the key areas. Email me if interested.

RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ https://genesdev.cshlp.org/content/40/3-4/185.full

Edinburgh University
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ genesdev.cshlp.org/content/early/2025/11/10...

#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

Calcium signaling-mediated phosphorylation controls zinc allocation in Arabidopsis - Stress Biology Zinc (Zn) deficiency in soil can directly result in Zn deficiency in crops, subsequently causing Zn deficiency in humans. Currently, the physiological adaptation mechanisms by which plants respond to ...

Calcium signaling-mediated phosphorylation controls zinc allocation in Arabidopsis

Yanjun Fang, Fangru Liu … Zhenqian Zhang, Chuanfeng Ju

link.springer.com/article/10.1...

#Phosphorylation #IonTransport #Nutrient #Calcium

Antibodies.com | Antibodies, Proteins, and ELISA Kits Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.

Using the phosphor-YAP1 (Ser128) antibody from antibodies.com, the group also revealed increased #YAP1 #phosphorylation in persister cells. We’re proud that our product, helped uncover the potential role of YAP-TEAD activity in supporting cell survival.

#Review in #MedComm
Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions doi.org/10.1002/mco2...

#AutoimmunePathologies #cancer #phosphorylation #PKC #TherapeuticTarget

Our proteomics experts Sibylle Pfammatter and Christian Panse attended HUPO 2025 in Toronto, presenting 3 posters on #glycosylation, #phosphorylation & integrative #PTM analysis. Great reconnecting with the community! #HUPO2025

With Team @carajgottardi.bsky.social ‘s expertise in cell-cell adhesion, we purified cadherin-associated catenins and profiled their proteoforms using I2MS and found #phosphorylation to be the MAJOR modification. (3/7)

Research Tip Sheet: Genetic Misfire in Lupus, UTI-Related Delirium | Newswise Learn more about the latest advances from Cedars-Sinai investigators.

Research Tip Sheet: Genetic Misfire in Lupus, UTI-Related Delirium
www.newswise.com/articles/res...

#neurosciencecriticalcare #brainfunctiondisturbance #memoryproblems #hallucinations #paranoia #braininjury #autoimmunedisease #phosphorylation

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

🔓 buff.ly/uGfbOBX

#Phosphorylation

Hey #phosphorylation folks! I've played around with some commercially available titanium dioxide resin for peptide-level enrichment, but I want to look at some phosphoproteins via western blot. What's the most cost effective way for protein-level phospho-enrichment? #chemsky #scisky

Switch on and off: Phospho‐events in light signaling pathways This review discusses how phosphorylation functions as a molecular switch to dynamically control light signaling, thus helping plants adjust their growth and development in response to light, improvi...

In a new review, Zhang and Liu explore the role of #phosphorylation as a molecular switch that dynamically controls #light signaling, helping #plants adjust their growth and development to adapt to changing light conditions.
doi.org/10.1111/jipb...
#PlantScience

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

To know more about this strange and intriguing case check out our work linked below (8/8)
#phosphorylation #epichaperome #cancer #conformation #cellstress
www.nature.com/articles/s41...

In #cancer, Casein Kinase 2 (CK2) interacts with #HSP90 and puts phosphate groups on Serine 255 and Serine 226 positions of the charged linker region of HSP90 thereby changing its structure or conformation. This dangerous alter ego of HSP90 helps the cancer cells to survive. (7)
#phosphorylation

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8)

#cancer #phosphorylation #epichaperome #conformation #cellstress

www.nature.com/articles/s41...

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

Featured today by @MSKLibrary: Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation

dx.doi.org/10.1038/s414...

#EpichaperomeResearch #CancerBiology #CellSignaling #Phosphorylation #MolecularChaperones #CellularAdaptability #BiomedicalResearch

Phosphorylation State Dictates Bacterial Stressosome Assembly and Function Bacterial pathogens rely on their ability to sense and respond to environmental stressors to survive and maintain virulence. The stressosome, a 1.8-megadalton nanomachine, serves as a critical sensor ...

🎉 Huge thanks to our incredible team, collaborators, and supporters! 🎉
Thanks to the powerful imaging capabilities @ UCSF!
Grateful to the NIH and CZ Biohub for making this research possible!
www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM #Microbiology #Phosphorylation #NIH #CZBiohub

Ligand recognition by 14-3-3 proteins: is #phosphorylation required?

➡️bit.ly/43jJLFq

#ProteinProteinInteractions

@westermarcklab.bsky.social proudly presents: The lab logo. Only took 23 years to have it done, but here it is. Big credits to Henok Karvonen at @turkubioscience.bsky.social for beautiful design. Embedded cancer cell #signaling by #phosphorylation and #dephosphorylation #phosphatase

The GSK3s-phyB-ELF3-HMR module regulates photobody formation under different temperature conditions.

#Phosphorylation of phyB by GSK3s, a key mechanism that brings temperature sensors together

📖 nph.onlinelibrary.wiley.com/doi/10.1111/nph.20232

👆 A #Commentary by Zubieta et al. on this article by Yang et al.
👇

📖 nph.onlinelibrary.wiley.com/doi/10.1111/nph.20064

#LatestIssue

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism ABSTRACT. The cadherin–catenin adhesion complex is a key contributor to epithelial tissue stability and dynamic cell movements during development and tissue renewal. How this complex is regulated to a...

For TOO LONG, we've been trying to crack the problem of AJ regulation, where we previously showed alpha-catenin undergoes #phosphorylation by a dual-kinase mechanism… 2/10 journals.biologists.com/jcs/article/...

Available online - the Review "Protein shapeshifting in #necroptotic cell death signaling" from @pseudokinase.bsky.social and colleagues.

#programmedcelldeath #kinase #pseudokinase #phosphorylation #proteinconformation

Read it here 👉 authors.elsevier.com/a/1kKdt3S6Gf...

Interesting! 😊
#Transcription #Termination #RNAPolII #CTD #Thr4 #Phosphorylation

Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses Bacteria and bacteriophages are in a constant arms race to develop bacterial defense and phage counter-defense systems. Currently known phage counter-defense systems are specific to (the activity of) ...

11/11 - Thanks to all involved - what a super collaboration! Savitski lab and @typaslab.bsky.social @embl.org with @alessioyang.bsky.social, @mgalactus.bsky.social / #phage #proteomics #phosphorylation #microbiology #PTMs

We are seeking a motivated PhD student to join our research group in Würzburg 🇩🇪! Explore fundamental mechanisms of #megakaryocyte development. #WürzburgPlateletGroup #Phosphorylation #PhDPosition #SingleCell Now also featured on #NatureCareers! 👉 www.nature.com/naturecareer...

Hello BlueSky! I’m a cell signaling biologist + Kinase enthusiasts. Looking forward to connecting with groups and labs working in the realm of post translational modifications! #kinase #phosphatase #cellsignaling #phosphorylation

We are seeking a motivated PhD student to join our research group in Würzburg 🇩🇪! Explore fundamental mechanisms of #megakaryocyte development in a collaborative environment #WürzburgPlateletGroup #Phosphorylation #PhDPosition
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...