Plant heat shock protein Hsp90 enhances stress resistance through integrating protein quality control, chloroplast protection, hormone signal network, and immune defense Hsp90 uses novel mechanisms in the regulation of proteostasis, chloroplast protection, phytohormone signaling, and immune defense to enhance plant adaptati

Plant #heat shock protein #Hsp90 enhances stress resistance through integrating #protein quality control, #chloroplast protection, #hormone signal network, and #immune defense

academic.oup.com/jxb/article-...

#PlantScience @jxbotany.bsky.social @sebiology.bsky.social @seanmichaletz.bsky.social

Development of Compact Sensor for Rapid Detection of Cancer Markers for Home Medical Monitoring A new compact sensor that quickly detects cancer markers like HSP90 is paving the way for early cancer detection and monitoring in home healthcare settings.

Development of Compact Sensor for Rapid Detection of Cancer Markers for Home Medical Monitoring #Japan #Tokyo #cancer_detection #Home_Healthcare #HSP90

がん早期発見を実現する小型センサの登場！在宅医療への道を切り開く 東京都立産業技術研究センターが開発した小型センサは、がんを早期に発見し治療をモニタリングする可能性を秘めています。注目です。

がん早期発見を実現する小型センサの登場！在宅医療への道を切り開く #都産技研 #HSP90 #がんマーカー

東京都立産業技術研究センターが開発した小型センサは、がんを早期に発見し治療をモニタリングする可能性を秘めています。注目です。

がんマーカーを迅速に検出する小型センサの開発とその応用 東京都立産業技術研究センターが、小型で簡便ながんマーカーの検出センサを開発しました。これにより在宅医療での早期発見が期待されます。

がんマーカーを迅速に検出する小型センサの開発とその応用 #東京都 #東京都立産業技術研究センター #がんマーカー #HSP90

東京都立産業技術研究センターが、小型で簡便ながんマーカーの検出センサを開発しました。これにより在宅医療での早期発見が期待されます。

Anti-HSP90 Antibody - Mouse Monoclonal [H9010] Order Mouse Anti-Human HSP90 Monoclonal IgG2a from StressMarq. Suitable for WB, IHC, ICC/IF, IP, ELISA, AM. High-quality antibodies for scientific research.

Product Citation 💡 A study conducted by Memorial Sloan Kettering Cancer Center used StressMarq's #HSP90 Antibody to present a method for disease-contextual mapping of protein-protein interaction (PPI) networks.

Paper 💐 http://bit.ly/434sZt3
Product 🌺 http://bit.ly/4oIQrnU

🚀From Bench to Paper | Research in Signal Transduction and Targeted Therapy highlights a promising #Nano-PROTAC for castration-resistant prostate cancer (#CRPC). This PSMA-targeted agent degrades #AR, its chaperone #HSP90, and resistant #AR-V7 (a splice variant).
A new way to beat CRPC resistance.

Researchers developed PSMA-targeted self-assembling Nano-PROTACs that simultaneously degrade AR, AR-V7, and #HSP90 in castration-resistant #ProstateCancer, achieving up to 78% #TumorInhibition and extended survival. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…

🚨Publication alert! The final version of our cover feature article is OUT NOW in @cp-trendsbiochem.bsky.social

Read how we connect the #epichaperome with the #chaperone code.

#PTMs #HSP90 #PPI #neuroscience #NetworkBiology
Check out the review article here: www.sciencedirect.com/science/arti...

📸Check out a few photos from @gabrielachiosis.bsky.social and Tanaya's talks at #CSSI2025 @stresscell.bsky.social l last weekend.
#epichaperome #cellularstress #HSP90 #Alzheimers

C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains Heat shock protein 90 (Hsp90) serves as a crucial regulator of cellular proteostasis by stabilizing and regulating the activity of numerous substrates, many of which are oncogenic proteins. Therefore,...

With growing interest in Hsp90 CTD inhibitors here's a reminder of our CTD study on yeast Hsp90. We showed the NTD and MD to modulate CTD dimerization and shape allostery; super relevant for CTD-targeted drug design #Hsp90 #allostery #DugDesign #Biophysics
www.cell.com/biophysj/ful...

Elysian Pickups HSP90 pickup with black limba top, black hex poles, and a secret inside (its hum canceling)

Elysian Pickups HSP90 pickup with black limba top, black hex poles, and a secret inside (its hum canceling)

Hum canceling HSP90 bobbin, wound with copper wire.

This HSP90 has a secret, can you spot it?

Been working on this one in the background for a while, still have some different things to try, but it's very close to launching.

#ElysianPickups #TunedAperture #metalguitar #metal #guitarpickups #guitarist #guitar #p90 #hsp90 #tone #guitarsky

Redirecting

🌟Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @cp-trendsbiochem.bsky.social
#PTMs #HSP90 #epichaperome #PPI #neuroscience @mskcancercenter.bsky.social
doi.org/10.1016/j.ti...

#3: #PhD Position on Structure–Dynamics–Function Relationship of the #Chaperone #Hsp90:

➤ NMR spectroscopy for atomic-resolution
➤ Single-molecule FRET for time-resolved dynamics
Collab.: @hillerlab.bsky.social & Schmid lab @unibas.ch

More info & online application system: tinyurl.com/mr2em3nk

Deeply saddened by the passing of Dr. Len Neckers-mentor, friend, and a giant in the field of molecular chaperones. I owe much of my career to him. His legacy will live on. My thoughts are with his family. #hsp90

In #cancer, Casein Kinase 2 (CK2) interacts with #HSP90 and puts phosphate groups on Serine 255 and Serine 226 positions of the charged linker region of HSP90 thereby changing its structure or conformation. This dangerous alter ego of HSP90 helps the cancer cells to survive. (7)
#phosphorylation

#Cancer is a multifactorial disease that manifests as a result of chronic cellular stress, a trigger that turns #HSP90 into Mr. Hyde.
Mr. Hyde can now associate with other chaperone protein members and form a gang (high molecular weight assembly) called “epichaperome”. (5)
#epichaperome

In our latest work, now published in
@natcomms.nature.com, we uncover how #HSP90 switches from “good” to “bad” in #cancer. (4)

Heat Shock Protein 90 (HSP90) is a cellular chaperone protein ubiquitously present in human body and is responsible for folding other important proteins in the cell. However, it can exist either as Dr. Jekyll or Mr. Hyde depending on how stressed the cells are. (3) #cellstress #HSP90

Any protein consists of strings of amino acids that fold into distinct different shapes and structures inside the cell depending on the cellular environment. (2)
#proteinstructure #HSP90 #chaperone #cancer #chembio

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8)

#cancer #phosphorylation #epichaperome #conformation #cellstress

www.nature.com/articles/s41...

New life chapter beginning! After some great years at the Sattler lab, I am returning to France with a permanent CNRS position at the CBS, in beautiful Montpellier!
I will continue my work on #HSP90 using #NMR and integrative approaches applied to a new and exciting project!

Curcumin compound reactivates Epstein–Barr virus, offering safer cancer therapy A novel curcumin derivative, C210, activates the Epstein–Barr virus (EBV) lytic cycle without producing infectious virions by disrupting HSP90. This discovery opens avenues for safer EBV-positive canc...

Curcumin compound reactivates Epstein–Barr virus, offering safer cancer therapy 🔬✨🌿 www.news-medical.net/news/2024110... #Curcumin #Cancer #EpsteinBarrVirus #HSP90 #LyticCycle #ViralTherapy #Oncology #Virus