🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne
We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!!
register here: us06web.zoom.us/webinar/regi...
1.5 years in!
I've switched to the phase lock tubes from LifeSct (M2302-20H), they work great for RNA-based assays www.lifesct.com/Phase-Lock-Gel
We are so excited to see our work out in @nature.com! We present a multi-omic single-cell atlas of 12 organs in human fetal development, explore the enhancer landscape, use deep learning to infer rules of transcription factor activity, and interpret non-coding variants in complex traits: #GeneReg 🧬🖥️
Grateful to have the opportunity to publish this review with Xiao Peng in Annual Reviews. We set out the challenges and opportunities to use information in rare disease diagnostics from the 98.8% of the human genome that does not encode genes.
www.annualreviews.org/content/jour...
Starting now! We've got two great talks coming up!
Join us this Wednesday to hear about fascinating research from @kashyapchhatbar.bsky.social and @a-radzisheuskaya.bsky.social!
If you're not already registered, click here to sign up: us06web.zoom.us/webinar/regi...
you can also join the conversation at our discord: discord.com/invite/dXqT89r
It’s well known that inflammation increases cancer risk, but how?
The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.
Here is our paper: nature.com/articles/s41...
And a special shoutout to the lead author
@snaga13.bsky.social
A 🧵
ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF
We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!
In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬
What does this unlock? ⬇️
Delighted to share the lab's latest led by superstar Janith and funded by @snowmedical.bsky.social.
What happens when embryonic factors are reawakened in cancers? We uncovered how DPPA2/4 amplify chromatin states in non-small cell lung cancer 🧬🔬🧪
genesdev.cshlp.org/content/earl...
Tutorial 👇 (1/8)
@mukherja.bsky.social work on RNAPII clusters is in print today: www.nature.com/articles/s41...
Congrats!
TLDR: RNAPII clusters represent transcriptonally engaged molecules at single genes, not super-stochiometric assemblies.
Please check it out and see the the thread below for a summary.
We have another exciting #FragileNucleosome seminar for you next week! @sunil-k-pradhan.bsky.social and
Genevieve Fourel will share their fascinating stories on chromatin and genome organization.
Click here to register: us06web.zoom.us/webinar/regi...
Looking forward to @kaiamattioli.bsky.social's visit to Montreal!
👇🏽👇🏽👇🏽👇🏽👇🏽
We often think of cell identity as the result of biochemical signals, soluble or membrane-bound. Join to the @fnucleosome.bsky.social seminar series if you would like to know more on how nanoscale extracellular topography can directly regulate cell identity in embryonic stem cells.
🕰️The next session of #FragileNucleosome seminar series due to switch to daylight saving in US will start at 4pm GMT (5pm CET) time.
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n
The team worked incredibly hard to get this out the door in time to share with grant review committees, and I am so grateful for their effort.
If you have thoughts, questions, or ideas for where this platform could (or should) go next, we would love to hear from you.
Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to a 1D axis.
Imagine if you could sample 200 dimensions at once, with data to boot 📈
First @chorylab.bsky.social PACE preprint on our new system to tackle this: bit.ly/turboprance
A reminder that we are actively recruiting a geneticist to the Department of Genetics at Albert Einstein College of Medicine
careers-einstein.icims.com/jobs/17847/a...
Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...
Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...
Saw a few papers recently in CNS injury using transgenic lines to target 'pericytes' in the CNS & broad markers that are not specific, also label fibroblasts - imprecise tools & language = assigning functions in fibrosis to pericytes when other cells like fibroblasts are primarily involved 1/4
Join us tomorrow for two exciting enhancer talks!
The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 !
www2.rnasociety.org
Next week on Fragile Nucleosome:
🧬 Pavan Choppakatla from the Levine lab will share his work on long-distance enhancer-promoter search
🧬 @moorejille.bsky.social will tell us about millions of enhancers in the registry of candidate CREs
Register here and join us!: us06web.zoom.us/webinar/regi...
Papers are like buses... You wait for ages, then two come along at once.
Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!
www.nature.com/articles/s41...
Our paper is now out in Nature:
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres.
1/14
Register for the Bay Area Chromatin Club in 2026! It’s free. March 5, 1-5pm Genentech Hall. We have speakers from UCSF, Stanford, Cal, and more ! It’s a great event for trainees to discuss their work and get feedback- bring a poster ! Hang with old and new friends.
urldefense.com/v3/__https:/...
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...